A quantitative assessment of dual energy computed tomography-based material decomposition for imaging bone marrow edema associated with acute knee injury.

PURPOSE: This study developed methods to quantify and improve the accuracy of dual-energy CT (DECT)-based bone marrow edema imaging using a clinical CT system. Objectives were: (a) to quantitatively compare DECT with gold-standard, fluid-sensitive MRI for imaging of edema-like marrow signal intensity (EMSI) and (b) to identify image analysis parameters that improve delineation of EMSI associated with acute knee injury on DECT images. METHODS: DECT images from ten participants with acute knee injury were decomposed into estimated fractions of bone, healthy marrow, and edema based on energy-dependent differences in tissue attenuation. Fluid-sensitive MR images were registered to DECT for quantitative, voxel-by-voxel comparison between the two modalities. An optimization scheme was developed to find attenuation coefficients for healthy marrow and edema that improved EMSI delineation, compared to MRI. DECT method accuracy was evaluated by measuring dice coefficients, mutual information, and normalized cross correlation between the DECT result and registered MRI. RESULTS: When applying the optimized three-material decomposition method, dice coefficients for EMSI identified through DECT vs MRI were 0.32 at the tibia and 0.13 at the femur. Optimization of attenuation coefficients improved dice coefficient, mutual information, and cross-correlation between DECT and gold-standard MRI by 48%-107% compared to three-material decomposition using non-optimized parameters, and improved mutual information and cross-correlation by 39%-58% compared to the manufacturer-provided two-material decomposition. CONCLUSIONS: This study quantitatively evaluated the performance of DECT in imaging knee injury-associated EMSI and identified a method to optimize DECT-based visualization of complex tissues (marrow and edema) whose attenuation parameters cannot be easily characterized. Further studies are needed to improve DECT-based EMSI imaging at the femur.

Impact of the rotational position of the hindfoot on measurements assessing the integrity of the distal tibio-fibular syndesmosis.

BACKGROUND: Approximately 20% of patients with ankle fractures demonstrate evidence of syndesmotic injuries. As intra-operative measurements have high specifity but low sensitivity for identifying injuries to the distal tibio-fibular syndesmosis, numerous measurements have been developed to assess pre-operative syndesmosis integrity. Several factors affecting measurements on conventional radiographs and computed tomography (CT) images have been identified. The influence of the rotational position of the hindfoot during imaging, however, remains unclear. METHODS: Twenty (20) healthy volunteers (mean age 49, standard deviation [SD] 7.5, range 40-66 years) underwent a weightbearing cone beam CT scan. From this dataset, digitally reconstructed radiographs (DRRs) and axial CT images of the hindfoot were reconstructed. For each image, an antero-posterior view (defined as a plane perpendicular to the longitudinal axis of the second metatarsal) was reconstructed. Then, internal and external rotation of the hindfoot was simulated in 10° increments (maximum rotation of 30°). The tibio-fibular clear space (TFCS), tibio-fibular overlap (TFO), and medial clear space (MCS) were measured on each reconstructed DRR and axial CT image. RESULTS: Internal rotation of the hindfoot substantially impacted inter-observer agreement for TFCS measurements on DRRs. Intra- und inter-observer agreement of measurements (MCS, TFCS, TFO) on axial CT images was minimally affected by hindfoot rotation. Hindfoot rotation highly impacted on absolute values of each measurement. As little as 10° of internal or external rotation significantly (P<0.05) impacted MCS and TFO measurements (DRRs and axial CT images). External rotation increased, while internal rotation decreased, MCS and TFO measurements. TFCS measurements performed on DRRs did not significantly differ for 10° (P=0.0931) and 20° (P=0.486) of external rotation or for 10° of internal (P=0.33) rotation. DISCUSSION: The rotational position of the hindfoot during imaging has a major impact on MCS, TFCS, and TFO measurements when using DRRs and axial CT images. To avoid misinterpretation of measurements, the position of the hindfoot during imaging must be standardized. CONCLUSIONS: DRRs and axial CT images require reliable reconstructions to allow accurate assessment of the TFCS, TFO, and MCS.

Cement Augmentation in Sacroiliac Screw Fixation Offers Modest Biomechanical Advantages in a Cadaver Model.

BACKGROUND: Sacroiliac screw fixation in elderly patients with pelvic fractures is prone to failure owing to impaired bone quality. Cement augmentation has been proposed as a possible solution, because in other anatomic areas this has been shown to reduce screw loosening. However, to our knowledge, this has not been evaluated for sacroiliac screws. QUESTIONS/PURPOSES: We investigated the potential biomechanical benefit of cement augmentation of sacroiliac screw fixation in a cadaver model of osteoporotic bone, specifically with respect to screw loosening, construct survival, and fracture-site motion. METHODS: Standardized complete sacral ala fractures with intact posterior ligaments in combination with ipsilateral upper and lower pubic rami fractures were created in osteoporotic cadaver pelves and stabilized by three fixation techniques: sacroiliac (n = 5) with sacroiliac screws in S1 and S2, cemented (n = 5) with addition of cement augmentation, and transsacral (n = 5) with a single transsacral screw in S1. A cyclic loading protocol was applied with torque (1.5 Nm) and increasing axial force (250-750 N). Screw loosening, construct survival, and sacral fracture-site motion were measured by optoelectric motion tracking. A sample-size calculation revealed five samples per group to be required to achieve a power of 0.80 to detect 50% reduction in screw loosening. RESULTS: Screw motion in relation to the sacrum during loading with 250 N/1.5 Nm was not different among the three groups (sacroiliac: 1.2 mm, range, 0.6-1.9; cemented: 0.7 mm, range, 0.5-1.3; transsacral: 1.1 mm, range, 0.6-2.3) (p = 0.940). Screw subsidence was less in the cemented group (3.0 mm, range, 1.2-3.7) compared with the sacroiliac (5.7 mm, range, 4.7-10.4) or transsacral group (5.6 mm, range, 3.8-10.5) (p = 0.031). There was no difference with the numbers available in the median number of cycles needed until failure; this was 2921 cycles (range, 2586-5450) in the cemented group, 2570 cycles (range, 2500-5107) for the sacroiliac specimens, and 2578 cycles (range, 2540-2623) in the transsacral group (p = 0.153). The cemented group absorbed more energy before failure (8.2 × 105 N*cycles; range, 6.6 × 105-22.6 × 105) compared with the transsacral group (6.5 × 105 N*cycles; range, 6.4 × 105-6.7 × 105) (p = 0.016). There was no difference with the numbers available in terms of fracture site motion (sacroiliac: 2.9 mm, range, 0.7-5.4; cemented: 1.2 mm, range, 0.6-1.9; transsacral: 2.1 mm, range, 1.2-4.8). Probability values for all between-group comparisons were greater than 0.05. CONCLUSIONS: The addition of cement to standard sacroiliac screw fixation seemed to change the mode and dynamics of failure in this cadaveric mechanical model. Although no advantages to cement were observed in terms of screw motion or cycles to failure among the different constructs, a cemented, two-screw sacroiliac screw construct resulted in less screw subsidence and greater energy absorbed to failure than an uncemented single transsacral screw. CLINICAL RELEVANCE: In osteoporotic bone, the addition of cement to sacroiliac screw fixation might improve screw anchorage. However, larger mechanical studies using these findings as pilot data should be performed before applying these preliminary findings clinically.