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1.
J Sci Food Agric ; 104(3): 1271-1281, 2024 Feb.
Article in English | MEDLINE | ID: mdl-37756429

ABSTRACT

BACKGROUND: In the present study, the ageing process of Sherry vinegar in used (seasoned) or new casks made of chestnut, American oak, Spanish oak or French oak wood has been investigated, considering that no research has investigated whether this seasoning has a definite influence on the final composition of the aged beverage. The polyphenolic and volatile contents of the aged vinegars were determined and their sensory properties were evaluated. Different statistical tools were applied to the data collected. RESULTS: With respect to polyphenolic contents, ageing time was the most influential factor, followed by the seasoned-cask factor. The type of wood was only significant for gallic acid, p-hydroxybenzoic acid, methylfurfural, ethyl gallate, ferulic acid, coniferyl aldehyde and sinapaldehyde. Principal component analysis according to polyphenols did not allow the samples to be differentiated, whereas cluster analysis revealed a slight grouping trend according to ageing time and seasoning of the wood. In relation to volatile compounds, variance analysis revealed that, again, ageing time and cask-seasoning were the most significant factors, with the samples clustering according to these two parameters. Following the sensory study, a clear difference between seasoned and new cask vinegars could be established as a result of the high scores in olfactory quality obtained for those vinegars aged in new casks. This was probably because of an excess of the descriptor 'ethyl acetate' exhibited by seasoned-cask Sherry vinegars. CONCLUSION: The previous seasoning of the casks together with the ageing time conditioned the composition of the vinegars aged in casks of different botanical origin, which translated into differences at a sensory level. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.


Subject(s)
Acetic Acid , Wine , Acetic Acid/analysis , Wood/chemistry , Wine/analysis , Cluster Analysis
2.
Foods ; 10(2)2021 Jan 31.
Article in English | MEDLINE | ID: mdl-33572649

ABSTRACT

Brandy de Jerez is a European Geographical Indication for grape-derived spirits aged in oak casks that have previously contained any kind of Sherry wine and, therefore, are known as Sherry Casks®. Wood compounds have a substantial influence in the quality of the brandies that are aged in the barrels. In the cellar, the barrels that have been used for many years to keep Sherry wine or other wine spirits are often used for this purpose. When wooden barrels are used for the first time, they release a large amount of compounds into the liquid contained in them. Such amount decreases over time but casks life cycle has remained unexplored until now. The present work has the aim to study the brandies obtained from the same wine spirit after two years ageing in three differently oak casks: namely new, 7 years of use (4 years containing Oloroso wine and 3 years containing wine spirits) and 32 years of use (8 years containing Oloroso wine and 24 years containing wine spirits). According to the results from our experiments, even after 32 years of use, the wood barrels still contribute to modify the organoleptic characteristics of brandy. Moreover, the brandies aged in used barrels were judged more balanced than those aged in new barrels.

3.
Ultrason Sonochem ; 69: 105244, 2020 Dec.
Article in English | MEDLINE | ID: mdl-32623345

ABSTRACT

In the present work, the accelerated ageing process of sherry vinegar has been studied at pilot scale by means of the joint application of ultrasound, micro-oxygenation and wood chips (American oak, French oak and Spanish oak). The CIELab parameters have been studied as well as the polyphenolic and volatile content of the aged vinegar samples. Vinegars aged with American oak presented different chromatic characteristics to those aged with French and Spanish oak and a lower polyphenolic and volatile content than the latter ones. On the other hand, Spanish oak generated vinegars with a higher content of volatile compounds and an intermediate polyphenolic profile between those obtained using French and American oak. In addition, the use of ultrasound for a period between 4 and 21 days, generated vinegars with similar characteristics to others that were aged in the traditional way for between 2 and 6 months. It has been demonstrated that the use of ultrasound, combined with micro-oxygenation and chip addition, is a technique which can accelerate the ageing process of vinegars at a pilot scale, so it could be a viable alternative to obtain sherry vinegars aged in a shorter time.


Subject(s)
Acetic Acid/chemistry , Food Handling/methods , Pilot Projects , Ultrasonics , Furans/chemistry , Phenols/chemistry , Quercus/classification , Time Factors , Volatile Organic Compounds/chemistry , Wood/chemistry
4.
Food Res Int ; 133: 109165, 2020 07.
Article in English | MEDLINE | ID: mdl-32466925

ABSTRACT

Accelerated maceration experiments of orange peels in Sherry vinegar employing ultrasounds (US) have been carried out. Their effect on the vinegars volatile composition as well as on its olfactometric and sensory characteristics have been evaluated. The optimal conditions for the ultrasounds were determined as follows: sonication power 550 W/L; pulses 40 s On and 20 s Off; with orange peel 200 g/L established previously. Statistical studies showed that maceration under ultrasounds increased volatile compounds content, since the vinegars obtained showed a high content in alcohols, aldehydes and terpenes. Regarding the olfactometric study, the control vinegar exhibited the lowest values for the "floral", "greasy" or "citric" categories and the highest value for the "sweet" category, whereas the US macerated vinegars presented the highest and lowest values for the "floral" and the "acid" categories, respectively. Based on their sensory evaluation, the panel members preferred the vinegar where orange peels had macerated under ultrasounds for 90 min. According to the results, ultrasound is a technology that could be employed to broaden the range of products manufactured by Sherry vinegar producers.


Subject(s)
Citrus sinensis , Wine , Acetic Acid/analysis , Flavoring Agents , Taste , Wine/analysis
5.
Foods ; 9(4)2020 Apr 03.
Article in English | MEDLINE | ID: mdl-32260147

ABSTRACT

In this study, a climate chamber, as an alternative method, has been used to dry raisins and the sensory profiles of the sweet sherry wines obtained have been evaluated. Other important factors, namely grape variety, vintage, vinification conditions, as well as the ageing method and its length of time, have also been considered. When heavy rainfall had been registered, the musts extracted from grapes dried under controlled conditions in a climate chamber showed a lower intensity of the musty off-odor compared to those elaborated with sun-dried grapes. The wine fermented at low temperature with Saccharomyces bayanus scored the highest in citric and floral notes, and this was preferred over all the other wines that were evaluated. The wines aged in oak barrels were preferred to both, wines aged in the presence of oak chips as well as those aged without any wood contact. The use of climate chambers to dry the grapes that are going to be used for the elaboration of sweet wines appears to be an advantageous alternative to the traditional method, since it allows a more precise control of the process and highly valued sweet wines from a sensory point of view are obtained thereby.

6.
Foods ; 9(3)2020 Feb 26.
Article in English | MEDLINE | ID: mdl-32110968

ABSTRACT

The use of alternative types of wood has arisen for the aging of the Brandy de Jerez, on a pilot plant level. In particular, besides the use of American oak, two more types of oak have been studied, French oak and Spanish oak, allowed by the Technical File for the ID Brandy de Jerez, and chestnut, which, though it is not officially allowed, is a type of wood which had been traditionally used in the area for the aging of wines and distillates. All of them have been studied with different toasting levels: Intense toasting and medium toasting. The study of the total phenolic composition (TPI), chromatic characteristics, organic acids, and sensory analysis have proven that chestnut leads to distillates with a higher amount of phenolic compounds and coloring intensity than oak. This behavior is the opposite as regards the toasting of the wood. Among the different types of oak, Spanish oak produces aged distillates with a higher phenolic composition and a higher color intensity. Regarding tasting, the best-assessed samples were those aged with chestnut, French oak, and American oak, and the assessors preferred those who had used a medium toasting level to those with an intense level.

7.
Foods ; 9(3)2020 Mar 03.
Article in English | MEDLINE | ID: mdl-32138227

ABSTRACT

The wine spirits used for the elaboration of Brandy de Jerez are mainly obtained from wines produced from the Airén type of grape, which comes from the vineyards located in the region of La Mancha (Central Spain). This entails a limitation when achieving a product classified as "protected geographic designation". For that purpose, it is necessary that the grape used for the wine spirit comes from the area and not from Castile la Mancha, as has happened until now. Due to this fact, it is necessary to search for a possible alternative grape variety which allows the produced brandy to be eligible for a "protected geographic designation". For that purpose, an accelerated ageing process has been implemented with a method previously optimized to distillates obtained from wines from different varieties of grapes (Airén, Colombard, Corredera, Doradilla, Garrido Fino, Jaén blanco, Moscatel de Alejandría, Palomino Fino, Ugni Blanc, and Zalema) grown in the Jerez Area. They were evaluated, both from the analytical and sensory points of view. The distillates made from Jaén Blanco and Zalema have properties that make them interesting for future development and incorporation into oenological practice.

8.
Food Chem ; 286: 275-281, 2019 Jul 15.
Article in English | MEDLINE | ID: mdl-30827606

ABSTRACT

Brandy de Jerez is the most produced spirit in Spain. The rules of its Regulatory Council require the spirit to age in American oak casks that have previously contained any kind of sherry wine. This use, called seasoning, releases wine compounds into the spirit. Because of the differences among sherries, the organoleptic features of a brandy will be significantly different from any other depending on the seasoning. In addition, its specific features make it different from any other spirit. The chromatographic profiles of Brandy de Jerez are reported to be different depending on the seasonings through their ageing process. Different types of Brandy de Jerez have been characterised, regarding their seasoning, using chromatographic techniques. Applying statistical analysis, correlations between the chromatographic profiles and the seasonings have risen up. In addition, the profiles have demonstrated to possess a high degree of correlation with the ageing time of the samples.


Subject(s)
Alcoholic Beverages/analysis , Phenols/chemistry , Chromatography, High Pressure Liquid , Cluster Analysis , Phenols/analysis , Principal Component Analysis , Spain , Sugar Acids/analysis , Wine/analysis
9.
Ultrason Sonochem ; 36: 226-235, 2017 May.
Article in English | MEDLINE | ID: mdl-28069205

ABSTRACT

During the ageing of brandies, many physicochemical processes take place involving the distilled spirit and the wood of the casks. Because of these reactions, the polyphenolic content of brandies and their content of organic acids increase with the ageing. These reactions are slow, and the ageing of high-quality brandies takes several years. In this paper, the development of a system that uses the circulation of the wine distillate through encapsulated American oak chips and the application of ultrasound energy with the aim of producing aged wine spirits has been carried out, and the influences of the operation variables over the characteristics of the produced drink have been measured. With that proposal, the influence of different powers of ultrasound, and also the influence of the movement of the liquor through oak chips, was determined first. This way, the results show that higher powers of ultrasound, of nearly 40W/L, in addition with the movement of the spirit, improve the extraction of phenolic compounds in a 33.94%, after seven days of ageing. Then, applying Youden and Steiner's experimental design, eight experiments of ageing were performed, and the samples obtained by this new method were analysed to obtain information related to their physicochemical and oenological characterisation in order to determine the experimental conditions that produce the best ageing results. This way, the best spirit produced by this new method of ageing is obtained with a high alcoholic strength of the distilled wine and a high quantity of oak chips, and with room temperature and high flow rate. In addition, the presence of oxygen in the sample and the absence of light increase the quality of the produced spirit. Finally, the application of ultrasound energy in large pulses is related with the improvement of two important ageing markers: the intensity of the colour and the TPI. As a last experiment, we applied this ageing method to five varietal spirits. The sensorial analysis of aged samples showed the aged spirits had better ratings than the initial distilled wine.


Subject(s)
Food Handling/methods , Laboratories , Ultrasonic Waves , Wine , Color , Kinetics , Phenols/analysis , Taste , Time Factors , Wood
10.
J Food Sci Technol ; 52(12): 7608-24, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26604338

ABSTRACT

Dietary fiber derived from citrus fruits was added to vinegar. Different sources and quantities of fiber and storage conditions have been scrutinized. Formulated vinegars were evaluated on the basis of their phenolic profile, volatile composition and sensory analysis. The addition of citrus fiber enhanced the phenolic and volatile profile of the resulted vinegars. Whereas lemon fiber contributed mostly to the enrichment of the polyphenolic composition, orange fiber was that which increased in a higher way the volatile composition of the vinegars. Moreover, the content of hydroxycinnamic acid derivatives and the majority of volatile compounds decreased as the dose of fiber increased. Furthermore, the judges preferred fiber-enriched vinegars, but in different quantities depending of the fiber source. This preference was mainly based on citric attribute, contributing several terpenes and ketones derived from them. The addition of citrus fiber to vinegar did not result in a marked storage-dependence.

11.
J Sci Food Agric ; 93(4): 741-8, 2013 Mar 15.
Article in English | MEDLINE | ID: mdl-22806566

ABSTRACT

BACKGROUND: Despite the long history of sherry wine vinegar, new alternatives of consumption are being developed, with the aim of diversifying its market. Several new acetic-based fruit juices have been developed by optimising the amount of sherry wine vinegar added to different fruit juices: apple, peach, orange and pineapple. Once the concentrations of wine vinegar were optimised by an expert panel, the aforementioned new acetic fruit juices were tasted by 86 consumers. Three different aspects were taken into account: habits of consumption of vinegar and fruit juices, gender and age. RESULTS: Based on the sensory analysis, 50 g kg(-1) of wine vinegar was the optimal and preferred amount of wine vinegar added to the apple, orange and peach juices, whereas 10 g kg(-1) was the favourite for the pineapple fruit. Based on the olfactory and gustatory impression, and 'purchase intent', the acetic beverages made from peach and pineapple juices were the most appreciated, followed by apple juice, while those obtained from orange juice were the least preferred by consumers. CONCLUSION: New opportunities for diversification of the oenological market could be possible as a result of the development of this type of new product which can be easily developed by any vinegar or fruit juice maker company.


Subject(s)
Acetic Acid , Beverages/analysis , Fruit , Magnoliopsida , Odorants , Taste , Adult , Age Factors , Aged , Aged, 80 and over , Ananas , Beverages/standards , Citrus , Consumer Behavior , Diet , Feeding Behavior , Female , Food Preferences , Humans , Male , Middle Aged , Prunus , Sex Factors , Wine , Young Adult
12.
J Agric Food Chem ; 58(24): 13006-12, 2010 Dec 22.
Article in English | MEDLINE | ID: mdl-21121626

ABSTRACT

During the drying process of raisins, the grapes are subjected to climatic variations that can result in heavy infections of some fungal species that produce ochratoxin A (OTA), a powerful toxic metabolite, whose maximum permitted content is set by the European Union at 2.0 µg/L for grapes, wine and other drinks derived from the grape. The aim of this paper is to optimize the process of making sweet wines in order to minimize the content of ochratoxin A. The results reflect a reduction of the OTA content in grapes dried under controlled conditions in a climatic chamber up to 24% compared to those sunned in the traditional way. A decrease of the concentrations of OTA is also observed during the processes of vinification. Those wines with prefermentative maceration reached a higher OTA content than the wines without maceration, but unexpectedly were not those preferred from a sensorial point of view. In addition, the process of aging in oak casks has been shown to serve as a natural method for reducing the OTA content of these wines.


Subject(s)
Food Handling/methods , Mycotoxins/analysis , Ochratoxins/analysis , Vitis/microbiology , Wine/analysis , Fermentation , Food Contamination/analysis , Fungi/metabolism , Industrial Microbiology , Mycotoxins/metabolism , Ochratoxins/metabolism , Vitis/chemistry
13.
J Agric Food Chem ; 58(22): 11814-20, 2010 Nov 24.
Article in English | MEDLINE | ID: mdl-21080728

ABSTRACT

Several experiments of maceration of a sherry wine vinegar with different fruits (orange, lemon, strawberry, grapefruit, and lime) have been carried out. After optimization (only peel, no heating and seven days as maximum time of maceration), parameters such as polyphenolic content, superoxide anion scavenging ability (related to antioxidant activity) and ascorbic acid content were determined in sherry wine vinegars macerated with two amounts of peel and for two maceration times (3 and 7 days). The analysis of variance pointed to a clear relationship (p<0.01) between type of fruit and amount of peel and polyphenolic content. The factor "time" was practically not significant for any polyphenol. Sherry wine vinegars macerated with different fruits exhibited higher superoxide anion scavenger ability, with the maximum values found for the vinegar macerated with lemon peel. The correlation analysis showed that the superoxide anion scavenger ability of the vinegars macerated, and thus their antioxidant activity, was highly correlated (p<0.01) with several polyphenols, especially with naringin, hesperidin, neohesperidin and gentisic acid and not with the ascorbic acid content.


Subject(s)
Acetic Acid/analysis , Antioxidants/analysis , Flavonoids/analysis , Fruit/chemistry , Phenols/analysis , Polyphenols , Wine/analysis
14.
J Agric Food Chem ; 58(2): 990-7, 2010 Jan 27.
Article in English | MEDLINE | ID: mdl-20020693

ABSTRACT

This article shows the results obtained in the study of the extraction profiles from oak wood to distillate of several compounds, low molecular weight phenolics, and furanic derivatives, and the relationship of their contents with those found in commercial sherry brandies and other aged distillates of different geographical origin, in order to research the utility of these analytical variables for explaining the highly specific character of Brandy de Jerez. Using multivariate statistic techniques, the aging system (static by anadas, or dynamic, well known as Soleras y Criaderas) has been confirmed as having a great influence on the analytical profile of aged distillates (discrimination is up to 100%). Differences between commercial brandies and those aged experimentally of equivalent average age have also been confirmed. The Solera Gran Reserva Brandies de Jerez show a clear differentiation from the rest of the distillates of different origin (discrimination is up to 80%), indicating their highly specific character.


Subject(s)
Furans/analysis , Phenols/analysis , Wine/analysis , Food Handling , Quality Control
15.
J Agric Food Chem ; 53(4): 1058-64, 2005 Feb 23.
Article in English | MEDLINE | ID: mdl-15713020

ABSTRACT

Brandy de Jerez is aged in American oak casks according to the traditional dynamic system (Soleras y Criaderas) and sometimes additionally by the static system (Anadas). The experimental arrangement used here for the analytical monitoring of brandy aging consisted of 15 casks, 12 of which were set up for aging by the dynamic system, which is well established in the denomination of origin area, whereas the other 3 contained the same brandy but aged according to the static system. This paper studies the kinetics of sugar extraction from oak wood to distillate, as well as the possible correlations between the sugar contents in brandy and its age or the commercial type it belongs to (Solera, Solera Reserva, or Solera Gran Reserva). High-performance anion-exchange chromatography with pulsed amperometric detection was used as the analytical tool to measure the concentrations of glucose, fructose, arabinose, galactose, and xylose, the presence of which in brandy has previously been described.


Subject(s)
Alcoholic Beverages/analysis , Carbohydrates/analysis , Food Handling/methods , Alcoholic Beverages/classification , Arabinose/analysis , Chromatography, High Pressure Liquid , Fructose/analysis , Galactose/analysis , Glucose/analysis , Kinetics , Quercus , Time Factors , Wood , Xylose/analysis
16.
Eur J Gastroenterol Hepatol ; 11(6): 649-53, 1999 Jun.
Article in English | MEDLINE | ID: mdl-10418937

ABSTRACT

UNLABELLED: OBJECTIVE; To evaluate the results of a large cohort of non-responder or relapsing responder patients with chronic hepatitis C retreated with various schedules of interferon (IFN). METHODS: Our study included 276 patients (158 non-responders and 118 relapsing responders) who underwent IFN retreatments. Among the non-responder group, 158 patients underwent further courses of IFN. In particular, 108 patients underwent one course of IFN retreatment, 40 patients underwent two courses, eight patients underwent three courses, and two patients underwent four courses. Regarding the relapsing responder group, the 118 patients were retreated with the same dosage for varying periods. In particular, 50 patients were treated for 6 months, 43 patients for 12 months, and 25 for 24 months. Patients in the subgroups of IFN retreatment were homogeneous as far as age and gender distribution, as well as virological and histological characteristics, are concerned. Qualitative and quantitative HCV-RNA was evaluated at baseline, at the end of treatment and at the last check-up of follow-up. HCV genotype was determined on baseline serum samples. Alanine transaminase (ALT) levels were tested monthly. RESULTS: Long-term biochemical (normal ALT levels) and virological (HCV-RNA negative) response was obtained in 2.6% of non-responder retreated patients, and in 33.9% of relapsing responder retreated patients. Evaluation of response on the basis of the duration of treatment showed that 48%, 19% and 16% of relapsing responder patients retreated for 24, 12 and 6 months, respectively, obtained long-term biochemical and virological response. CONCLUSION: Non-responder patient retreatment is inefficient especially in cirrhotic and/or genotype 1 b patients. IFN retreatment is warranted in relapsing responder patients. In particular, 24-month therapy induces significant long-term biochemical and virological response.


Subject(s)
Antiviral Agents/therapeutic use , Hepatitis C, Chronic/therapy , Interferon-alpha/therapeutic use , Patient Selection , Aged , Alanine Transaminase/blood , Antiviral Agents/administration & dosage , Female , Genotype , Hepacivirus/genetics , Hepatitis C, Chronic/enzymology , Humans , Interferon-alpha/administration & dosage , Male , Middle Aged , RNA, Viral/analysis , Retreatment , Retrospective Studies , Treatment Outcome
17.
Aliment Pharmacol Ther ; 12(1): 63-8, 1998 Jan.
Article in English | MEDLINE | ID: mdl-9692703

ABSTRACT

BACKGROUND: No randomized double-blind studies have been performed to compare clarithromycin 1 g/day with higher doses of the macrolide (1.5 g/day) when combined with ranitidine bismuth citrate (RBC). AIM: To compare H. pylori eradication and ulcer healing rates of RBC 400 mg b.d. for 4 weeks combined for the first 2 weeks either with clarithromycin 500 mg b.d. (Group A) or clarithromycin 500 mg t.d.s. (Group B). METHODS: Two hundred and seventy-three patients with H. pylori-positive active duodenal ulcer were included. H. pylori infection was detected by CLO-test and histology on antral and corpus biopsies before and at least 4 weeks after the end of therapy. Eradication was assumed if both CLO-test and histology results were negative for H. pylori. RESULTS: Eradication/healing rates according to intention-to-treat and per protocol analysis were 76/82% and 87/92% for Group A and 78/85% and 88/95% for Group B, respectively (P = N.S.). Adverse events were reported by 7% and 12% of patients in Groups A and B, respectively, and they were generally mild. CONCLUSIONS: RBC in co-prescription with clarithromycin 500 mg b.d. is as effective as RBC plus clarithromycin 500 t.d.s. in eradicating H. pylori and healing duodenal ulcers.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Anti-Ulcer Agents/therapeutic use , Bismuth/therapeutic use , Clarithromycin/therapeutic use , Duodenal Ulcer/drug therapy , Helicobacter pylori/drug effects , Histamine H2 Antagonists/therapeutic use , Ranitidine/analogs & derivatives , Adolescent , Adult , Aged , Aged, 80 and over , Anti-Bacterial Agents/administration & dosage , Anti-Ulcer Agents/administration & dosage , Bismuth/administration & dosage , Child , Child, Preschool , Clarithromycin/administration & dosage , Dose-Response Relationship, Drug , Drug Therapy, Combination , Duodenal Ulcer/microbiology , Female , Histamine H2 Antagonists/administration & dosage , Humans , Male , Middle Aged , Ranitidine/administration & dosage , Ranitidine/therapeutic use
18.
Scand J Gastroenterol ; 30(6): 535-41, 1995 Jun.
Article in English | MEDLINE | ID: mdl-7569760

ABSTRACT

BACKGROUND: In a significant number of patients affected by the irritable bowel syndrome, an adverse reaction to food is proposed to be a causative factor. A diet that eliminates the offending foods is the obvious treatment for such adverse reactions. Compliance with a dietetic regimen is often poor and sometimes not completely free from risks. METHODS: Since the diarrheic type of irritable bowel syndrome seems mainly affected by food intolerance, and previous observations suggested that oral cromolyn sodium is effective in such patients, a multicenter therapeutic trial in the diarrheic type of irritable bowel syndrome was carried out in 346 of 409 patients with this disease, to evaluate the effects of oral cromolyn sodium and compare its efficacy with that of an elimination diet. RESULTS: Symptoms related to the irritable bowel syndrome improved in 60% of patients treated with elimination diet and in 67% of those treated with oral cromolyn sodium (1500 mg/day) for 1 month. Moreover, in both groups clinical results were significantly better in the patients positive to the skin prick test than in the negative ones. CONCLUSIONS: These results confirm the high prevalence of adverse reactions to foods in diarrheic irritable bowel syndrome and the usefulness of cromolyn sodium treatment in these patients.


Subject(s)
Anti-Allergic Agents/therapeutic use , Colonic Diseases, Functional/diet therapy , Colonic Diseases, Functional/drug therapy , Cromolyn Sodium/therapeutic use , Administration, Oral , Adolescent , Adult , Aged , Aged, 80 and over , Anti-Allergic Agents/administration & dosage , Colonic Diseases, Functional/etiology , Colonic Diseases, Functional/physiopathology , Cromolyn Sodium/administration & dosage , Diarrhea/etiology , Female , Food Hypersensitivity/physiopathology , Food Hypersensitivity/therapy , Humans , Male , Middle Aged , Prognosis , Treatment Outcome
19.
Eur J Gastroenterol Hepatol ; 7(1): 25-8, 1995 Jan.
Article in English | MEDLINE | ID: mdl-7866806

ABSTRACT

OBJECTIVE: To evaluate the effectiveness of sulglycotide, a gastroprotective drug, as maintenance treatment for patients with duodenal ulcer. DESIGN: A randomized double-blind study. METHODS: A total of 119 patients with recently healed duodenal ulcers were randomly allocated, in a double-blind fashion, to receive sulglycotide 200 mg twice daily (60 patients) or placebo (59 patients) for 1 year. Patients underwent clinical assessment every third month and endoscopy at 6 and 12 months, or earlier if relapse was suspected. RESULTS: The cumulative endoscopic relapse rates, compared using the log rank test, were 37 and 52% after 6 and 12 months, respectively, in the sulglycotide group and 62 and 71% (P = 0.03), respectively, in the placebo group. CONCLUSIONS: Sulglycotide is moderately effective as a maintenance treatment for duodenal ulcer disease.


Subject(s)
Anti-Ulcer Agents/therapeutic use , Duodenal Ulcer/prevention & control , Sialoglycoproteins/therapeutic use , Anti-Ulcer Agents/adverse effects , Double-Blind Method , Female , Humans , Male , Middle Aged , Recurrence , Sialoglycoproteins/adverse effects
20.
Gut ; 34(2 Suppl): S126, 1993.
Article in English | MEDLINE | ID: mdl-8314477

ABSTRACT

In a study of 60 patients with non-A, non-B/type C (NANB/C) chronic hepatitis alanine aminotransferase (ALT) activities returned to normal after treatment with interferon alfa-2b (3 million units for six months) in 70.7% and 29.3% did not respond. The response was maintained during four to six months, follow up in 41.4% of patients. Liver biopsy specimen showed histological improvement in all patients surveyed. Treatment was well tolerated with only mild side effects.


Subject(s)
Hepatitis C/therapy , Interferon-alpha/therapeutic use , Adolescent , Adult , Aged , Alanine Transaminase/blood , Chronic Disease , Female , Hepatitis C/enzymology , Hepatitis C/pathology , Humans , Interferon alpha-2 , Liver/pathology , Male , Middle Aged , Pilot Projects , Recombinant Proteins , Time Factors
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