1.
Am J Hematol
; 21(4): 415-8, 1986 Apr.
Article
in English
| MEDLINE
| ID: mdl-3953560
ABSTRACT
The presence of teardrop-shaped red cells in peripheral blood has traditionally been felt to reflect altered marrow architecture, namely myelofibrosis. We evaluated two patients with splenomegaly, moderately severe hemolytic anemia due to warm-reactive IgG anti-red cell autoantibody, and bone marrow erythroid hyperplasia without myelofibrosis. A striking predominance of teardrop-shaped red cells was noted upon examination of their blood films. Removal of a spleen containing extramedullary hematopoiesis in one and resolution of splenomegaly in the other were accompanied by disappearance of these cells. Our observations support a role for the spleen and for extramedullary hematopoiesis in the pathogenesis of this distinctive red cell morphologic abnormality.
Subject(s)
Anemia, Hemolytic, Autoimmune/blood , Erythrocytes, Abnormal/pathology , Spleen/physiopathology , Anemia, Hemolytic, Autoimmune/diagnosis , Anemia, Hemolytic, Autoimmune/physiopathology , Bone Marrow/pathology , Diagnosis, Differential , Female , Hematopoiesis , Humans , Male , Middle Aged , Primary Myelofibrosis/diagnosis , Spleen/pathology , Splenectomy
2.
N Engl J Med
; 303(12): 704, 1980 09 18.
Article
in English
| MEDLINE
| ID: mdl-6931288
Subject(s)
Chromosome Aberrations , Leukemia/genetics , Bone Marrow Cells , Female , Genetic Markers , Humans , Karyotyping , Middle Aged , Prognosis
3.
Br J Haematol
; 27(2): 345-55, 1974 Jun.
Article
in English
| MEDLINE
| ID: mdl-4843677
Subject(s)
Anemia, Aplastic/complications , Hepatitis A/complications , Adolescent , Adult , Androgens/therapeutic use , Anemia, Aplastic/blood , Anemia, Aplastic/drug therapy , Anemia, Aplastic/pathology , Biopsy , Blood Cell Count , Bone Marrow/pathology , Female , Hematopoietic Stem Cells , Hepatitis A/blood , Hepatitis A/drug therapy , Hepatitis A/pathology , Humans , Leukocyte Count , Liver/pathology , Male , Neutrophils , Syndrome
4.
Ann N Y Acad Sci
; 232(0): 125-34, 1974.
Article
in English
| MEDLINE
| ID: mdl-4528763
Subject(s)
Thalassemia , Adult , Anemia, Hypochromic/etiology , Anemia, Sideroblastic/etiology , Black People , Blood , Blood Transfusion , Erythrocyte Count , Erythrocytes/cytology , Erythrocytes, Abnormal , Female , Hematocrit , Hemoglobin C/analysis , Hemoglobin, Sickle/analysis , Hemoglobins , Hemoglobins, Abnormal/analysis , Heterozygote , Humans , Infant, Newborn , Pedigree , Pregnancy , Pregnancy Complications, Hematologic , Thalassemia/genetics , Thalassemia/therapy , Umbilical Cord , United States
5.
Br J Haematol
; 18(2): 211-28, 1970 Feb.
Article
in English
| MEDLINE
| ID: mdl-4314767
Subject(s)
Anemia, Hypochromic/genetics , Intestinal Absorption , Iron/metabolism , Anemia, Hypochromic/enzymology , Anemia, Hypochromic/metabolism , Animals , Blood Volume , Catalase/analysis , Cobalt/metabolism , Copper/metabolism , Electron Transport Complex IV/analysis , Female , Genes, Recessive , Iron/blood , Iron Isotopes , Malabsorption Syndromes/genetics , Male , Mice , Sex Chromosomes , Triolein/metabolism , Zinc/metabolism
6.
Hum Hered
; 19(6): 613-27, 1969.
Article
in English
| MEDLINE
| ID: mdl-5399259
Subject(s)
Diabetes Mellitus/epidemiology , Hyperglycemia/epidemiology , Adult , Aged , Blood Glucose , Female , Fertility , Humans , Indians, North American , Male , Middle Aged , Obesity
7.
Diabetes
; 18(1): 38-43, 1969 Jan.
Article
in English
| MEDLINE
| ID: mdl-5761867
Subject(s)
Diabetes Mellitus/epidemiology , Insulin/blood , Obesity , Adult , Blood Glucose/analysis , Body Height , Body Weight , Female , Glucose Tolerance Test , Humans , Indians, North American , Insulin Resistance , Male , Middle Aged , New York
8.
Acta Genet Stat Med
; 18(3): 251-60, 1968.
Article
in English
| MEDLINE
| ID: mdl-5301686
Subject(s)
Color Vision Defects/genetics , Dermatoglyphics , Gene Frequency , Glucosephosphate Dehydrogenase Deficiency/genetics , Haptoglobins , Hemoglobinopathies/genetics , Indians, North American , Transferrin , Ear, External , Electrophoresis , Female , Fingers , Humans , Male , New York , Toes
9.
Am J Hum Genet
; 19(6): 700-12, 1967 Nov.
Article
in English
| MEDLINE
| ID: mdl-6075365
