Oclacitinib 10 years later: lessons learned and directions for the future.

Oclacitinib was approved in the United States 10 years ago for the management of atopic dermatitis (AD) and allergic skin disease in dogs. Many studies and case reports have been published in the past 10 years on the efficacy and safety of this medication, both at labeled doses to treat allergic dogs and off label to treat other diseases and given to other species. Concerns and confusion have occurred for both clinicians and owners regarding the long-term safety of this drug. The purpose of this review is to present the current knowledge on the efficacy, speed of action, effects on the immune system, and clinical safety of oclacitinib, based on evidence and published literature. We also aim to summarize the lessons learned in the past 10 years and to propose directions for the future.

Changing the gendered status quo in engineering? The encouraging and discouraging experiences of young women with engineering aspirations.

Young women remain underrepresented among engineering bachelor's degree holders. While there is a relatively large body of extant research on the many factors that curtail young women's interest in pursuing engineering, less is known about high school girls who are on an engineering pathway. Therefore, this study focuses on a select group of precollege young women who express a strong interest in engineering. Specifically, informed by theories of gender as a social system and previous empirical research, this mixed-methods study explores the constellation of significant actors within the daily lives of these young women, to understand from whom and how they are supported in pursuing this gender-atypical field, and simultaneously, from whom and how they are discouraged. To do so, the researchers analyzed survey and interview data from a sample of diverse high school girls who participate in the Society of Women Engineers' (SWE) SWENext programme. Quantitative results indicate that young women report high levels of encouragement from most sources, including parents, teachers, and other young women. However, across various peer contexts, they receive much more support from other young women than from young men. Qualitative results further reveal that parents and teachers stand out in young women's recollections of encouragement, often through advocating their participation in engineering activities or providing mentoring support. In contrast, young men in engineering spaces were recalled as particularly discouraging of their engineering participation, by socially or physically excluding them or refusing to provide recognition. Implications for future research and practice are discussed.

Making Merit Work at the Entrance to the Engineering Workforce: Examining Women's Experiences and Variations by Race/Ethnicity.

This study utilizes interviews from 22 young female engineers from diverse racial/ethnic backgrounds as they first entered the White and male-dominated engineering labor force with the goal of examining: (1) how these women endorsed a gender-blind frame that characterizes their workplaces as fundamentally meritocratic, and alternatively, (2) how they named gender as relevant or salient to experiences and interactions at work. Drawing on the insights of intersectional scholars to answer the previous questions, the study calls attention to how the invocation of these frames differed for women of color compared to their majority White female peers. Results revealed that most respondents strongly endorsed the idea that engineering workplaces are meritocratic and that their gender is not relevant. However, there is also evidence of racial divergence in the themes expressed. For example, some White women expressed a narrative contradictory to meritocracy, discussing their workplaces as like family, while in contrast, women of color often expressed uncomfortable experiences of standing out. Overall, the results suggest that female engineers' tendency to disavow, either explicitly or implicitly, that discrimination and bias occurs in their workplaces, likely contributes to continued gender and racial inequality; subsequently, programs and interventions to facilitate awareness of inequality are critically needed.

Calcinosis cutis in dogs: histopathological and clinical analysis of 46 cases.

BACKGROUND: Calcinosis cutis is well recognized in dogs with endogenous hyperglucocorticism and iatrogenic hyperglucocorticism, but the pathogenesis is still unclear. OBJECTIVES: The objectives of the study were to identify possible correlations between histopathological patterns of dermal mineralization in skin biopsies and underlying causes for calcinosis cutis in dogs, as well as to determine breed predilection and age of onset for dogs within a hospital population. In addition, mineral analysis was performed on four biopsy samples. ANIMALS: Forty-six dogs with histopathologically confirmed calcinosis cutis were evaluated. METHODS: Medical records and histological sections of dogs with calcinosis cutis diagnosed by histopathology over a 21 year period were reviewed. Infrared spectrometry was used to identify the mineral in the paraffin blocks. Exact chi-squared test was used to identify breed predispositions, while a Mann-Whitney U-test was used to identify age correlations. RESULTS: Labrador retrievers, Rottweilers, boxers and Staffordshire terriers were the breeds most commonly affected in this study. Most dogs had either an exogenous or an endogenous source of corticosteroids, with the exception of five dogs with renal insufficiency. In the majority of cases, mineralization was found throughout the entire dermis. The average age of onset of calcinosis cutis for dogs with endogenous hyperglucocorticism was older than that of dogs with iatrogenic hyperglucocorticism. Using infrared spectrometry, apatite crystals were found to be the source of mineral. CONCLUSIONS AND CLINICAL IMPORTANCE: There was no observable difference in the histopathological pattern of calcinosis cutis from dogs with endogenous hyperglucocorticism versus iatrogenic hyperglucocorticism. While glucocorticoid therapy appears to predispose dogs to developing calcinosis cutis, it remains unclear whether there is a specific dose or combination of factors that initiates the mineral deposition. Furthermore, the mineral deposition in dogs with calcinosis cutis was found to be apatite.

Functional anatomy and pathophysiology of axial low back pain: disc, posterior elements, sacroiliac joint, and associated pain generators.

Careful consideration of functional lumbosacral anatomy reveals the capacity for pain generation in the disc, zygapophysial joint, sacroiliac joint, and surrounding ligaments. However, the methods used to definitively implicate a particular anatomic structure in axial low back pain have limitations. Anatomically and biomechanically, the discs and posterior elements are inextricably connected to a dynamic biotensegrity network of ligaments, muscles, and fascia. This article examines key lumbosacral anatomic structures and their functional interdependence at the macroscopic, microscopic, and biomechanical level. Particular attention is given to the capacity of each structure to generate low back pain.

Transmission electron microscopy studies in an experimental model of canine atopic dermatitis.

Impairment of skin barrier function has been hypothesized in canine atopic dermatitis (AD). In this prospective, controlled study, the ultrastructure of the upper epidermal layers was investigated using an experimental model of canine AD. Seven atopic Beagles sensitized to Dermatophagoides farinae and four healthy Beagles were used as controls. Both normal and atopic dogs were challenged with D. farinae for 3 days. Clinical signs were scored and skin biopsies were taken from the inguinal area before and 3 days after allergen exposure. Samples were processed to enhance lipid visibility and evaluated by Transmission Electron Microscopy. Emphasis was placed on evaluation of the lipid lamellae (LL), and lamellar bodies (LB) of the stratum corneum.After allergen challenge, atopic Beagles developed severe pruritic dermatitis while no skin lesions were noted in the controls. Ultrastructurally, before allergen challenge, atopic Beagles displayed focally severe abnormalities in LL organization and wider intercellular spaces containing abnormal lipid material. In atopic Beagles, LBs were frequently found inside corneocytes while this finding was not observed in the controls. After allergen challenge, further increase of intercellular spaces was observed in the stratum corneum of atopic Beagles while no appreciable changes were observed in the normal dogs. Intercellular spaces in atopic Beagles were filled with abundant amounts of abnormal lipid material and highly disorganized LL. It is concluded that baseline differences in the ultrastructure of the skin exist between normal and experimentally sensitized atopic Beagles and that these changes are aggravated by allergen challenge and the resulting flare-up of dermatitis.