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1.
Am J Med Sci ; 346(5): 381-4, 2013 Nov.
Article in English | MEDLINE | ID: mdl-23276902

ABSTRACT

BACKGROUND: Circulating insulin-like growth factor (IGF)-1 and IGF-binding protein (IGFBP)-3 levels in the serum of Helicobacter pylori (H pylori)-infected patients were investigated. METHODS: The study subjects consisted of 54 patients with H pylori infection, and the control subjects included 27 patients without H pylori infection. There was no statistical difference in the age and sex distributions between the study and control groups. Pretreatment serum levels of IGF-1 and IGFBP-3 were studied in all the subjects, including the healthy controls. H pylori eradication was achieved with a triple drug regimen for 2 weeks, and 1 month after this treatment, the serum levels of IGF-1 and IGFBP-3 were measured. The post-treatment H pylori status by a second gastroscopy, antral histopathology and urea breath testing was tested. RESULTS: The pretreatment serum levels of IGF-1 and IGFBP-3 of the study and control groups were not found to be different (P > 0.05). H pylori treatment was successful in 42 patients in whom both serum IGF-1 and IGFBP-3 levels decreased with treatment, but the difference was only significant for the serum IGF-1 levels (P: 0.04). There was no change in the serum levels of IGF-1 and IGFBP-3 in the 27 patients with precancereous gastric lesions before and after successful H pylori eradication. CONCLUSIONS: No supporting evidence of a major interaction between H pylori infection itself and H pylori-associated premalignant lesions with circulating IGFBP-3 levels could be shown. Nevertheless, successful eradication of this microorganism led to a statistically significant decrease in serum IGF-1 levels.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Helicobacter Infections/drug therapy , Helicobacter pylori , Insulin-Like Growth Factor Binding Protein 3/blood , Insulin-Like Growth Factor I/metabolism , Precancerous Conditions/blood , Stomach Neoplasms/blood , Adult , Aged , Aged, 80 and over , Case-Control Studies , Drug Therapy, Combination , Female , Gastroscopy , Helicobacter Infections/blood , Humans , Male , Middle Aged , Precancerous Conditions/pathology , Pyloric Antrum/metabolism , Pyloric Antrum/pathology , Stomach Neoplasms/pathology , Treatment Outcome
2.
Kulak Burun Bogaz Ihtis Derg ; 11(1): 17-20, 2003 Jul.
Article in English | MEDLINE | ID: mdl-14676478

ABSTRACT

We presented a case of Kaposi's sarcoma that occurred in the external ear of a 36-year-old Caucasian man. He was otherwise healthy without a history of any predisposing factors. He had a nodular lesion in the left ear, of three-month duration. The lesion was excised completely. Histologic and immunohistologic findings were consistent with a diagnosis of Kaposi's sarcoma. Serologic analyses were negative for anti-HIV antibody and anti-cytomegalovirus IgM and IgG and blood count was normal. Differential count of leucocytes and immunoglobulin electrophoresis were normal. During a two-year follow-up, no recurrences, development of new lesions, or HIV seroconversion were detected. To our knowledge, this case is the first to report a solitary lesion of Kaposi's sarcoma occurring in the helix of the ear in a healthy young patient.


Subject(s)
Ear, External , Sarcoma, Kaposi/diagnosis , Skin Neoplasms/diagnosis , Adult , Diagnosis, Differential , Humans , Male , Sarcoma, Kaposi/pathology , Sarcoma, Kaposi/surgery , Skin Neoplasms/pathology , Skin Neoplasms/surgery
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