ABSTRACT
INTRODUCTION: Cutaneous metastatic disease arising from urinary tract carcinoma is rare and associated with a poor prognosis. We report a case of metastatic disease occurring in a patient treated for synchronous urothelial tumor of the bladder and left renal pelvis. CASE PRESENTATION: A 61-year-old Caucasian man was treated for a synchronous urothelial tumor of the bladder and left renal pelvis. He had an en bloc radical cystectomy and left ureteronehprectomy associated with a cutaneous transileal urinary diversion and lymph node dissection. He was scheduled for chemotherapy but was lost to follow-up. He consulted 1 year later with growing skin tumors that were confirmed to be metastatic disease, and he was referred to the oncology department for palliative chemotherapy. CONCLUSION: Cutaneous metastatic disease is a rare entity with poor prognosis. The main treatment remains chemotherapy; however, single-site metastasis should be considered for metastasectomy.
Subject(s)
Kidney Neoplasms/pathology , Neoplasms, Second Primary/diagnosis , Skin Neoplasms/diagnosis , Skin Neoplasms/secondary , Urinary Bladder Neoplasms/pathology , Urinary Bladder/pathology , Biopsy , Fatal Outcome , Humans , Kidney Neoplasms/surgery , Kidney Pelvis/pathology , Kidney Pelvis/surgery , Male , Middle Aged , Tomography, X-Ray Computed , Urinary Bladder/surgery , Urinary Bladder Neoplasms/diagnosis , Urinary Bladder Neoplasms/surgery , Urothelium/pathology , Urothelium/surgeryABSTRACT
Glassy cell carcinoma is a rare neoplasm that occurs most frequently in the uterine cervix. We describe the second reported case of glassy cell carcinoma arising in the vagina. We present a case of a 24-year-old woman with a history of post-coïtal bleeding associated with menometrorrhagia. Different explorations have concluded in a glassy cell carcinoma arising in the vagina, with clinical staging III according to the International Federation of Obstetrics and Gynecology. The patient received three cycles of neoadjuvant chemotherapy with a good response. Then she had a para-aortic lymphadenectomy and ovarian transposition. Following the surgery, she had radiotherapy. The gynecological examination showed no budding lesion and the biopsy was negative. Six months later, the patient complained of a pelvic pain. The examination revealed a locoregional recurrence. Surgical revision was not possible and the patient was a candidate for a palliative chemotherapy. Although, glassy cell carcinoma runs an aggressive clinical course, an early diagnosis may help in a more effective management and offer a better prognosis.
Subject(s)
Carcinoma, Adenosquamous/therapy , Neoplasm Recurrence, Local/therapy , Vaginal Neoplasms/therapy , Female , Humans , Young AdultABSTRACT
Vaginal rhabdomyoma is an extremely rare tumor which presents as a vaginal polypoid masses. It is essential to differentiate it from benign and malignant mimickers so that appropriate therapy may be provided. The present report describes a vaginal wall nodule of a symptomatic 24-year-old woman. Local excision and subsequent pathological examination were performed. The final diagnosis was vaginal rhabdomyoma. The literature is reviewed and differential diagnosis are discussed.
Subject(s)
Polyps/diagnosis , Rhabdomyoma/diagnosis , Vaginal Neoplasms/diagnosis , Diagnosis, Differential , Female , Humans , Polyps/pathology , Rhabdomyoma/pathology , Vaginal Neoplasms/pathology , Young AdultABSTRACT
Renal cell carcinoma is a rare pediatric malignant tumor of the kidney. Unlike Wilms tumor, the efficacy of chemotherapy and radiation therapy in pediatric renal cell carcinoma remains uncertain. Surgery is the best treatment and prognosis is favorable when the tumor is localized and completely eradicated. We report an exceptional observation in a 7-year-old girl with renal cell carcinoma who had been treated 20 months previously for Ewing sarcoma with chemotherapy and radiotherapy. The renal tumor was revealed by abdominal pain without hematuria. She underwent a radical nephrectomy, and histopathology concluded in renal carcinoma associated with translocation Xp 11.2 grade 3 of Furhrman pT3a N1. No adjuvant therapy was given. After 3 years of follow-up, there is no evidence of local or metastatic recurrence. This observation is significant given the very young age of this patient, the occurrence after Ewing sarcoma with a short disease-free interval. It seems that translocation renal cell carcinoma is associated with previous exposure to chemotherapy, particularly topoisomerase II inhibitors or alkylating agents.
Subject(s)
Bone Neoplasms , Carcinoma, Renal Cell , Kidney Neoplasms , Neoplasms, Second Primary , Sarcoma, Ewing , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics , Bone Neoplasms/therapy , Carcinoma, Renal Cell/diagnosis , Carcinoma, Renal Cell/genetics , Carcinoma, Renal Cell/therapy , Child , Female , Humans , Kidney Neoplasms/diagnosis , Kidney Neoplasms/genetics , Kidney Neoplasms/therapy , Neoplasms, Second Primary/diagnosis , Neoplasms, Second Primary/genetics , Neoplasms, Second Primary/therapy , Sarcoma, Ewing/therapy , Translocation, GeneticSubject(s)
Astrocytoma/pathology , Brain Neoplasms/pathology , Neoplasm Recurrence, Local , Astrocytoma/radiotherapy , Astrocytoma/surgery , Brain Neoplasms/radiotherapy , Brain Neoplasms/surgery , Child, Preschool , Diagnosis, Differential , Humans , Male , Neoplasm Invasiveness , Neoplasm Recurrence, Local/pathology , Prognosis , Radiotherapy, Adjuvant , Treatment Failure , Treatment OutcomeABSTRACT
Endometrial stromal sarcoma (ESS) is rarely localized in extrauterine sites if metastasis or local extension of the primary uterine tumour are excluded, and diagnosis can be delayed because of the unusual site. We report a case of abdominal ESS in a 45-year-old woman who presented with an abdominal complaint. Ultrasound of the abdomen showed a large multiloculated cystic mass. The complete excision of the tumour revealed ESS arising in endometriosis. The tumour expressed hormonal receptors and the patient was administered hormonal therapy. ESS has a better prognosis than the sarcoma that is part of differential diagnosis, and is associated with endometriosis in about one-half of cases.
Subject(s)
Abdominal Neoplasms/pathology , Endometriosis/pathology , Sarcoma, Endometrial Stromal/pathology , Abdominal Neoplasms/metabolism , Abdominal Neoplasms/surgery , Cysts/pathology , Diagnosis, Differential , Female , Gastrointestinal Stromal Tumors/pathology , Humans , Immunohistochemistry , Middle Aged , Nerve Sheath Neoplasms/pathology , Sarcoma/pathology , Sarcoma, Endometrial Stromal/metabolism , Sarcoma, Endometrial Stromal/surgery , Sarcoma, Synovial/pathologyABSTRACT
Carotid paraganglioma (CP) is a relatively rare neoplasm, most commonly located in the head and neck. It is a slow-growing tumor and there has been some debate on the optimal techniques of excision. We report herein the case of a 35-year-old woman who presented with an asymptomatic mass in the right side of the neck. The diagnosis of CP was confirmed by computed tomography and carotid angiography. This tumor was successfully removed surgically without complication. Throughout the description of this case, we analyze the clinical, radiological, pathological and therapeutic particularities of this entity.
Subject(s)
Carotid Body Tumor/diagnostic imaging , Carotid Body Tumor/surgery , Paraganglioma/diagnostic imaging , Paraganglioma/surgery , Adult , Carotid Body Tumor/pathology , Cell Division , Cytoplasm/pathology , Female , Humans , Paraganglioma/pathology , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
Mucinous tubular and spindle cell carcinoma is a rare and newly described type of renal cell carcinoma (RCC) with a relatively indolent behaviour. We report a case of 53-year-old woman who had macroscopic hematuria and flank pain. A right radical nephrectomy was performed showing a well circumscribed tumour confined to the kidney and measuring 17cm. The histologic findings consisted of tightly packed, small, elongated tubules separated by pale mucinous stroma. The tumour cells were cuboidal to spindled with eosinophilic cytoplasm and lower nuclear grade. Tumour was immunoreactive for cytokeratin CK 7, CK19 and epithelial membrane antigen (EMA). The morphological and immunohistochemical features were consistent with mucinous tubular and spindle cell carcinoma of kidney.
Subject(s)
Adenocarcinoma, Mucinous/pathology , Carcinoma, Renal Cell/pathology , Carcinoma/pathology , Kidney Neoplasms/pathology , Adenocarcinoma, Mucinous/chemistry , Adenocarcinoma, Mucinous/surgery , Biomarkers, Tumor/analysis , Carcinoma/chemistry , Carcinoma/surgery , Carcinoma, Renal Cell/chemistry , Carcinoma, Renal Cell/surgery , Female , Humans , Immunohistochemistry , Keratin-19/analysis , Keratin-7/analysis , Kidney Neoplasms/chemistry , Kidney Neoplasms/surgery , Middle Aged , Mucin-1/analysis , Nephrectomy , Treatment OutcomeABSTRACT
Desmoplastic fibroblastoma is a benign, rare, slow-growing soft tissue tumor which is found in a wide anatomic distribution, predominantly in adult males. The characteristic gross aspect is that of a typical cartilage-like tumor which histologically presents regular fibroblastic proliferation, often in a stellar shape within a dense collagen or myxo-collagen stroma. We report a new case observed in the foot and study the anatomic and clinical aspects of this rare entity.
Subject(s)
Fibroma, Desmoplastic , Foot Diseases , Soft Tissue Neoplasms , Adult , Female , Fibroma, Desmoplastic/diagnostic imaging , Fibroma, Desmoplastic/pathology , Fibroma, Desmoplastic/surgery , Follow-Up Studies , Foot/pathology , Foot Diseases/diagnosis , Foot Diseases/diagnostic imaging , Foot Diseases/pathology , Foot Diseases/surgery , Humans , Immunohistochemistry , Magnetic Resonance Imaging , Soft Tissue Neoplasms/diagnostic imaging , Soft Tissue Neoplasms/pathology , Soft Tissue Neoplasms/surgery , Time Factors , Tomography, X-Ray ComputedABSTRACT
Sclerosing hemangioma of the lung is a rare lesion described for the first time in 1956 by Liebow. We report a case in a 45 year-old woman who was admitted for exploration of chronic cough. The chest x-ray revealed a round opacity, well delimited in the left pulmonary parenchyma. Surgical resection enabled the histopathological diagnosis of sclerosing hemangioma. We review progress in our knowledge of the histogenesis and diagnosis of this tumor. Immunohistochemistry has been highly contributory although numerous points remain controversial.