Conservative treatment of ectopic pregnancy in a sub-Saharan African setting.

In the sub-Saharan African setting, laparotomy for salpingectomy is the common method of treatment for ectopic pregnancy (EP). The objective of this retrospective study was to find out how common EP is treated conservatively in the Yaounde Gynaeco-Obstetric and Paediatric Hospital, Cameroon. Of the 281 patient files analysed, 126 patients (44.8%) were treated conservatively and successfully for EP. Of these, 86 (68.2%) had received conservative surgical treatment while 40 (31.8%) had non-surgical treatment. Salpingostomy was the conservative surgery for 79.1% of the cases. According to the publications available for the sub-Saharan setting, the rate of conservative management of EP at the Yaounde Gynaeco-Obstetric and Paediatric Hospital, Cameroon is high. We recommend that this rate should be improved so that, eventually, the conservative treatment methods of EP become routine.

Geographic Distribution of Childbirth among Adolescents in Cameroon from 2003 to 2005.

Objective. To determine the frequency and the trend of adolescents (10-19 years) in childbirth within a period of 3 years in referral maternity units in Cameroon. Method. Descriptive and retrospective study for a 3-year period (2003-2005) in referral maternity units headed by a qualified Obstetrician-Gynecologist. We analyzed the trend and geographic distribution of 8222 adolescent deliveries over 3 years. Epi Info 3.5 software was used for data analysis. Chi square test for trend was used to assess the contribution of adolescent deliveries over years. The trend was considered significant if P < .05. Results. During the period of the study, there was a total of 8387 deliveries. We excluded 165 women because of lack of information about age. We therefore included a total of 8222 adolescent deliveries. Overall, the contribution of adolescents to deliveries ranged from 6.87% to 26.51%, depending on the region with a national mean of 14.23%. Adolescents aged 16 or less contributed to 2.82% of deliveries while those aged from 17 to 19 contributed to 11.41%. The contribution of adolescents to deliveries decreased significantly over 3 years (P < .0001). Conclusion. The study underscores the importance of Public Health programs in strengthening maternity services for adolescents in Cameroon while taking into consideration geographic differences.

[Complications of laparoscopic surgery in gynecology unit A of Yaoundé General Hospital, Cameroon]. / Les complications de la coeliochirurgie dans le service de gynécologie A de l'hôpital général de Yaoundé, Cameroun.

The aim of the study was to describe the morbidity and mortality of gynaecological laparoscopy in a pilot center of Cameroon. It was a monocentric retrospective study over a period of seven years. All files of patients who had laparoscopic surgery in the service were reviewed. Files with incomplete information were excluded. Complications were defined as an event that had modified the usual cause of the procedure or of the postoperative period. They were classified as surgical complications (during insertion of Veress needle and trocarts, intraoperative and postoperative complications) also reorganised as major and minor complications and anaesthetic complications. The rate of laparoconconversion was noted. The data of 609 patients was gathered and examined. Their mean age was 31.57 (19-63years). The mean parity and gestity was 0.77 and 1.82, respectively. The common findings in their past history were sexually transmitted infection (39.9%), criminal abortions (35.03%) and previous surgery (39.1%). Infertility was the main indication of the surgery (76.3%) followed by postmyomectomy adhesiolysis (15%). The main operative findings were adhesions (78.16%). The mortality rate is 0.16%. The surgical morbidity rate is 2.46% with 0.99% of complications during insertion of Veress needle and trocarts and 1.48% during surgery. Among these complications, 1.8% were minor complications and 0.66%, major ones. Five patients had complications due to anaesthesia (0.82%). Postoperative complications (8.3%) were of low gravity and were mainly digestive, infectious and moderate vaginal bleeding. The rate of laparoconversion was 2.46%, mainly due to difficulties during surgery. This study shows that operative gynaecologic laparoscopy is associated with acceptable mortality and morbidity rate in our milieu.

Effectiveness of vaginal hysterectomy for benign conditions in semi-urban hospital: report from Maroua-Cameroon.

We assessed the effectiveness of vaginal hysterectomy for benign uterine conditions in Northern Cameroon. This is a case series study of 29 elective vaginal hysterectomies carried out between February 2005 and June 2007 in Maroua, Cameroon. Hysterocele was found as the only or associated indication in 17 (58.6%) patients, symptomatic uterine fibroids in 4 (13.8%) and other indications in 8 (27.6%) patients. The mean duration of the operation was 132 minutes and the mean blood loss at surgery was 150 ml. Twenty-five of the 28 (89.3%) women had less than seven days of hospitalisation. There was a negative correlation (r = -0.45, P = 0.015) between duration of the surgery and the order of operation. One urinary tract and one wound infection were observed. Two patients had conversion to laparotomy. This study has shown that vaginal hysterectomy is a safe and feasible method of hysterectomy in a semi-urban hospital.

Epidémiologie clinique du cancer du sein chez les moins de 40 ans

Le cancer du sein du sujet age de moins de 40 ans represente un probleme rare. Nous avons realise une analyse retrospective sur 133 patients qui nous a permis de montrer la place de ce cancer dans cette tranche d'ages. Nous avons ainsi recense 34;5de cas par rapport a l'ensemble des cancers du sein a l'hopital de Yaounde. Un antecedent familial de cancer et la multiparite ont ete les facteurs de risque les plus retrouves; respectivement 11 et 9 sur 32. Au moment du diagnostic la majorite des malades etaient au stade metastatique. Ce travail considere preliminaire nous a permis d'avoir une idee sur le profil de la camerounaise jeune atteinte du cancer du sein

[Historical cohort study of delivery in women of forty years of age and older]. / Etude cohorte historique de l'accouchement a 40 ans et plus a Yaoundé-Cameroun.

In a recent study at the Yaounde-Cameroon University Teaching Hospital, we found that delivery at extreme ages of reproductive health was associated with increased foetal and maternal risks. However we were not able to evaluate the impact of advanced age on exposure do different risks observed. The purpose of this study was to test the hypothesis that deliveries of women aged 40 years and above were associated with increased risk. Data collection was retrospective from delivery room registers at the Yaoundé University Teaching Hospital Between 01/01/1991 - 31/12/2000. The deliveries of 180 women in their forties were compared with those of 532 women in their twenties. The software EPI Info 6 and SPSS were used in analysis. At unvaried analysis, the risk of delivery by caesarean section for women in their forties (16.1%) was significantly high compared to women in their twenties (10.0%), (HR: 1.7; 95% CI: 1.1-2.8; p = 0.027). After adjustment for different factors associated with the occurrence of delivery by caesarean section, its risk for women aged 40 and above remained significantly increased (HR: 1.7; 95% CI: 1.0-2.9; p = 0.039). Similar observation was found for stillbirth with 11.7% by women aged 40 and above compared to 5.8% by women in their twenties (HR: 2.1; 95% CI: 1.1-3.9; p = 0.011). After adjustment for different factors associated with mortinatality, its occurrence remained significantly increased at age 40 and above (HR: 1.9; 95% CI: 1.1-3.6; p = 0.032). Women aged 40 years and above had an increased risk of stillbirth and delivery by caesarean section than those in their twenties. Studies are needed to establish the exact causes of these risks and evaluate management options in these women.

Vaginal delivery after caesarean section: a propective study of 146 cases.

We report on a series of 146 cases of vaginal delivery after previous Caesarean section conducted between 1993 and 2002 at the University Teaching Hospital, Yaounde (Cameroon). During the period under review 945 cases of Caesarean section were done out of a total of 9 439 deliveries (10 %). Delivery was spontaneous in 141 cases whereas in 5 cases it was assisted by vacuum extraction. In 13 cases Caesarean section was carried out after failure of trial of labour. Maternal mortality, resulting from pulmonary embolism, was observed in 1 case. We conclude that strict selection of patients who had previous Caesarean section for trial of labour renders vaginal delivery a safe alternative to Caesarean section.

Prevention of mother-to-child transmission of HIV in Cameroon: experiences from the University Teaching Hospital in Yaounde (Cameroon).

OBJECTIVE: The aim of this study was to assess the effectiveness of nevirapine (NVP) in the prevention of mother-to-child transmission (MTVT) of HIV-1 in children in the Yaounde University Teaching Hospital, Cameroon. METHODS: This was a prospective and descriptive hospital-based study in which pre-counselled HIV-infected pregnant women who gave their consent were included. At the onset of labour a single dose of 200 mg oral NVP was administered to each woman. Their newborns were also given 2 mg/kg of oral NVP syrup within 72 hours of their birth. These NVP-treated babies were assessed at 6 weeks, 6 months and between 15 and 18 months for viral load levels, using a branched DNA technology. Viral load levels were classified as undetectable (< 50 copies/ml); intermediate (50-3 500 cp/ml) or high (> 3 500 cp/ml). RESULTS: Of the 350 women screened for HIV 22 (6.3 %) were positive for HIV-1, but only 18 children were duly tested until 18 months. Viral load levels were undetectable at 6 weeks in 61.1 % of the children; intermediate in 38.9 % and no child had a high VL (> 3 500 cp/ml). At 6 months 5 of 7 children with intermediate levels had dropped to undetectable levels. By 15-18 months, a total of 16 children (88.9 %) had undetectable levels while 2 children (11.1 %) with detectable levels were confirmed to be HIV positive using ELISA test and immunoblot analysis. CONCLUSIONS: We conclude that the rate of HIV-1 MTCT with NVP is about 11 % in CHU Yaounde.

Visual inspection with acetic acid and cytology as screening methods for cervical lesions in Cameroon.

OBJECTIVES: To assess the accuracy of visual inspection with acetic acid (VIA) as a screening method for cervical lesions. METHODS: VIA and cytological smears were carried out on the cervices of non-pregnant women aged 30-60 years with no previous history of cervical cancer. Cervices with aceto white lesions or positive Pap smears, and one in ten negative cervices (control), were biopsied. RESULTS: 5010 women were enrolled, 4813 (96.1%) were screened. 4767 (99.%) had adequate cytology smears. 574 (11.9%) had colposcopy. 1743 biopsies were obtained of which 528 were controls. The sensitivity of VIA was 70.4% versus 47.7% for Pap smear. VIA specificity was 77.6% versus 94.2% for Pap smear; PPV for VIA was 44.0% versus 67.2% for Pap smear; and NPV for VIA was 91.3% versus 87.8% for Pap smear. CONCLUSIONS: VIA has acceptable test qualities and may in low resource settings be implemented as a large scale screening method.

[Outcome of delivery at extreme ages of reproductive life]. / Devenir de l'accouchement aux âges extrêmes de la vie reproductive.

BACKGROUND: Deliveries in adolescents and in elderly are separately known as associated with high foetal and maternal risks. The purpose of this study was to test the hypothesis that the outcome of deliveries might be comparable in these distinct age groups. POPULATION AND METHODS: The deliveries of 99 adolescents aged 16 and under were compared with that of 183 women aged 40 years and above with respect to complications of the delivery and the outcome of pregnancy. Data collection was retrospective using delivery room registers from 01/01/1991 to 31/12/2000. RESULTS: Some risks were comparable in both groups as delivery by caesarean section, intra uterine growth retardation, and stillbirth. Other risks were significantly higher in teenagers as post-term delivery, premature delivery, and neonatal foetal distress. The risk of macrosomia was significantly higher in aged women. CONCLUSION: There are risks that are similar in both extremes of age. Other risks are higher particularly in teenagers or in aged women. A common prenatal care unit can be used for these two categories of population, but a few different practices will have to be considered according to the specific age group.

[Fetal ultrasound biometry in a Cameroonian population: study of femur length]. / Biométrie foetale ultrasonore sur une population Camerounaise: étude de la longueur du fémur.

The length of the fetal femur was measured by fetal ultrasonography in Cameroonian population as a preliminary step in constructing local curves for fetal growth. This prospective cross-sectional study was conducted in 3 centers in Yaoundé, Cameroon over a period of one year. A total of 803 pregnant women (mean age, 27.15 years) knowing the exact date of the last menstrual period (LMP) were included. Based on ultrasound findings demonstrating a single fetus with normal development. Gestational age ranged from 12 to 42 weeks of amenorrhea (WOA). The mean length of the femur increased from 16.61 +/- 2.25 mm at 13 WOA to 75.36 +/- 4.85 mm at 42 WOA. There was a good correlation with gestational age and findings reported in the literature. Curves obtained using these data were compared with those in the literature. In most cases femur lengths measured in Cameroonian fetuses were slightly longer than European standards throughout pregnancy.

[Neurological disorders and endemic goiter: comparative analysis of 2 provinces in Togo]. / Affections neurologiques et endémie goitreuse: analyse comparative de deux provinces du Togo.

Neurological diseases are one of the main causes of high mortality and morbidity in developing countries. The prevention of these diseases is possible if they are well known. The purpose of this study was to evaluate the prevalence and the distribution of the main neurological affections in two rural districts. WHO research protocol for measuring the prevalence of neurological disorders in developing countries was used by the same staff. The first survey was conducted in Kloto from July to August 1989 on 19,241 inhabitants and the second in Akébou from January to February 1995 on 4182 subjects. Akébou was known as endemic goiter district. The prevalence of epilepsy was 12.3@1000 in Kloto and 13.1@1000 in Akébou. That of stroke was 2.4@1000 in Kloto versus 1.7@1000 in Akébou. The prevalence of Parkinson's disease was 0.2@1000 in Kloto and 0.2@1000 in Akébou. That of psychomotor retardation was 3.2@1000 in Kloto versus 8.1@1000 in Akébou. The prevalence of neurological cretinism was 97@1000 while that of myxoedematous cretinism was 31@1000 in Akébou. Apart from neurological disease, the prevalence of goitre was 43% in females and 26.1% in males in Akébou. Mental retardation and cretinism were frequent in Akébou, a district endemic for goitre. Besides stroke and febrile convulsions which predominated in Kloto, the main neurological disorders were most prevalent in Akébou. Community based care for epilepsy is provided in these districts as is the prevention of iodine deficiency in the Akébou district with the intention of reducing neurological affections.

An advanced case of double primary malignancy involving the breasts and uterine cervix: satisfactory response to non-surgical management.

Double primary cancers are fairly rare. We report here a case of metachronous lesions; advanced cancer of the breasts and squamous cell carcinoma of the cervix. What is peculiar in this case is the rather unusual positive response to conservative treatment. Despite widespread metastases even to the liver, the patient is well and active more than six years after breast cancer was first diagnosed. Treating such advanced cases may be rewarding at times.

[Anatomical-clinical presentation and prognostic factors in cancers of the cervix at the General Hospital of Yaounde]. / Presentations anatomo-cliniques et facteurs pronostiques des cancers du col uterin a l'hôpital General de Yaounde.

The objective of this work was to search for and precise all the facts related to clinical anatomo and the prognosis capable of individualising the sick in our midst. We proposed to analyse 111 files of cases treated for the cancer of the uterine neck in the gynaecology services and cancerology-radiotherapy in the General Hospital, Yaounde. All the facts related to the clinical anatomo presentations of the patients were noted as well as the therapeutic results in accordance with the facts and the technical means of treatment. All these facts have been compared to the ones of the literature. We established that the clinical anatomo presentation of the cases in our series is comparable to the one of the literature taking into account the previous history, the general state, the symptoms and the clinical signs. On the other hand, it differs relatively by the important proportion of the young, the long diagnosis delay, the importance of the extensive stages and the additional prognosis factors in relation with the inadequacy of technical means of treatment. In conclusion, a lucid reorientation of our policy to fight against cancers in general and of cancer of the uterine neck in particular that takes into account the reality of the data based on the clinical and prognosis facts of our patients is needed.

The management of pre-invasive cervical lesions using cryotherapy in Yaounde, Cameroon.

Cervical cancer is the commonest gynaecological malignancy in developing countries. The pre-invasive lesion often starts more than a decade before it becomes overt cancer. In this study most patients were in their third or fourth decade of life and had been pregnant at least once. Cryotherapy has been shown in this study to be an effective method of treating pre-invasive lesions. The cure rate after 1 year follow-up following single treatment was 93.1%. Follow-up visits are important and can improve the results to near perfection if patients are properly selected for such conservative management. The complication rate of cryotherapy is low and mainly involves excessive mucoid discharge which lasts for a few weeks. It is our opinion that the technique be popularised in developing countries, as a cost-effective method for the management of pre-invasive lesions.

[Treatment of early T1 small T2N breast cancers. Our experience at the Yaounde General Hospital. 21 cases]. / Traitement des cancers du sein aux stades précoces T1 petit T2 N-notre experience a l'Hôpital Général de Yaoundé. A propose de 21 cas.

From February 1989 through February 1993, a group of 23 patients suffering from T1 mammary carcinoma small T2 N-MO was treated in the radiotherapy department of the Yaoundé General Hospital, according to a simplified procedure. A first conservative surgery of tumorectomy type (3 cases) and quandrantectomy type (4 cases) was carried out, followed by a postoperative irradiation. In 14 cases, a Patey type radical surgery preceded a local/regional radiotherapy. The general treatment was made up of only a hormonotherapy without chemotherapy. After a 4-year decline, there were 5 cases--i.e. 23.8%--of ganglionic and/or metastatic relapse. In the light of research data, we are analysing the reasons for these unexpected therapeutic failures in this group of tumor considered as favorable prognosis. We raised the problem of the inability of the prognosis factors, presently defined by means of histological and biological factors, to detect all the especially aggressive cancers. We carried out a general review of the new factors defined essentially from molecular and genic bases. We offered an approximative solution which makes it possible to by-pass the technological difficulties in having access to the new factors.

Purification of a leucine aminopeptidase from Eimeria falciformis.

A leucine aminopeptidase was purified from the oocysts of Eimeria falciformis using affinity chromatography and gel filtration techniques. It had a molecular weight of 45-50 kDa. Its maximal activity against leucyl-p-nitro anilide was at pH 8.6. It is a metallo-enzyme highly inhibited by bestatin.

Outcome of twin deliveries at the University Teaching Hospital, Yaoundé, Cameroon-a 15-year experience.

From 1982 to 1996, a total of 16 181 deliveries was registered at the obstetric unit of the Yaoundé University, Cameroon, out of which 291 were twins (1.8%). For the latter, the average gestational age was 37 +/- 2.9 weeks. In 45.0% of cases both fetuses presented cephalic, in 42.6% one presented cephalic and the other breech, while both fetuses presented as breech in 9.9% of cases. The frequency of the combination cephalic-transverse was 0.05%. Spontaneous delivery of both babies was observed in 90.2% of the patients, while in 9.7% delivery of both babies was by caesarian section. The caesarian section rate for a retained second twin was 1%. The perinatal mortality rate was 65 per 1000 (38 deaths in the first week of life), out of which the fetal loss was 4.4% for the first twin compared with 7.9% for the second. The perinatal mortality for the second twin was significantly associated with the type of fetal presentation at the time of delivery, as well as the time gap between the delivery of the twins. Sixteen deaths were observed amongst second twins after podalic presentation out of a total of 23 deaths recorded in the group. In addition, the mortality rate among second twins born more than 20 minutes after expulsion of the first was four times higher than in those delivered within 20 minutes time interval (16.0%5 versus 4.3%). The main cause of twin deaths in our study was found to be prematurity which complicated 30 cases of the registered deaths (78.9%).