ABSTRACT
SUBJECTS: Between August 2003 and January 2008, 35 patients with primary breast cancer received preoperative systemic chemotherapy(PSC). METHODS: The subjects were divided into 4 groups based on the expressions of ER, PgR, and HER2: luminal A and B, HER2, and basal-like groups. FEC75 followed by docetaxel was administered preoperatively. However, a regimen with trastuzumab was employed after 2006. RESULTS: The subjects consisted of 1 male and 34 females, with a mean age of 56.0 years. In 65.7% of these, axillar lymph node metastasis was detected before surgery: 13 patients in the luminal A, 4 in the luminal B, 13 in the HER2, and 5 in the basal-like groups. A clinical complete response(cCR)was achieved in 25.7% of the patients, and a partial response in 62.9%; the response rate was 88.6%. Pathologically, the grade was evaluated as 3 in 14.3% of the patients and 2 in 48.6%. In the basal-like and HER2 groups, the cCR and pCR rates were higher than those in the luminal groups. Combination therapy with trastuzumab was not effective in the HER2 or luminal B group. DISCUSSION: This simple classification method may be useful for predicting the effects of PSC.
Subject(s)
Breast Neoplasms/drug therapy , Breast Neoplasms/metabolism , Receptor, ErbB-2/metabolism , Adult , Aged , Antibodies, Monoclonal/therapeutic use , Antibodies, Monoclonal, Humanized , Breast Neoplasms/immunology , Breast Neoplasms/surgery , Combined Modality Therapy , Female , Humans , Immunotherapy , Male , Middle Aged , TrastuzumabABSTRACT
OBJECTIVE: To determine death rates from gastric cancer when using endoscopic screening. MATERIAL AND METHODS: In this historical cohort study comprising 11,763 participants aged from 40 to 75 years without gastric disorders between 1990 and 1992, 2192 were examined by gastric endoscopy while 9571 were not examined by endoscopy or X-ray. The relative risk of gastric cancer death was compared between the two groups. RESULTS: When screened with endoscopy, 41 patients were diagnosed with gastric cancer and the ratio of early cancer was 78%. On matching the population-based cancer registry (the Fukui Cancer Registry), 63 patients in the examined group were diagnosed with gastric cancer within 10 years after the initial screening including the above 41 patients. In the non-examined group, 147 patients were diagnosed with gastric cancer in the same period. In the examined and non-examined groups, 5 and 63 patients, respectively, died from gastric cancer. The relative risk for gastric cancer death in the examined group was 0.3465 (95% CI: 0.1396-0.8605) when compared with the non-examined group. For male patients, the relative risk was 0.2174 (95% CI: 0.0676-0.6992). CONCLUSIONS: The death rate from gastric cancer decreased when endoscopic screening was used. Endoscopy is recommended as a population-based screening method for gastric cancer in regions or countries where mortality from this disease is high.
Subject(s)
Gastroscopy/statistics & numerical data , Mass Screening/mortality , Stomach Neoplasms/diagnosis , Stomach Neoplasms/mortality , Adult , Age Distribution , Aged , Cohort Studies , Combined Modality Therapy , Disease-Free Survival , Female , Humans , Japan/epidemiology , Male , Mass Screening/methods , Middle Aged , Outcome Assessment, Health Care , Probability , Prognosis , Reference Values , Registries , Risk Assessment , Sensitivity and Specificity , Sex Distribution , Stomach Neoplasms/therapy , Survival AnalysisABSTRACT
SUBJECTS: The subjects were patients with resectable breast cancer who visited our department between August 2003 and November 2004, did not have any other risk factors defined in the St. Gallen Consensus Conference,and were receptor-negative or had axillary lymph node metastasis. METHODS: The histological type, ER, PgR, HER2, and histological grade were evaluated by needle biopsy. Four courses of CEF (5-FU: 500 mg/m(2)+EPI: 75 mg/m(2)+CPA: 500 mg/m(2)) were performed at 3-week intervals, followed by 4 courses of Docetaxel (70 mg/m(2)). RESULTS: Treatment was performed in 14 patients including a male. Their age ranged from 37 to 69 years (mean, 55.3 years). Stage IIA was observed in 5 patients, IIB in 4, IIIA in 1, and IIIB in 4. In patients with Grade 3 or more, leukocytopenia was observed in 7 patients and diarrhea in 1 as adverse events. CR was obtained in 6 patients, PR in 5, and NC in 3 (response rate, 78.5%). Pathological examination showed pCR in 1 patient and pPR in 10 (response rate, 78.5%). Of the 10 patients with pPR, 2 showed a state near pCR. DISCUSSION: Our results showed the safety and effectiveness of preoperative chemotherapy with CEF followed by Docetaxel.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Breast Neoplasms/drug therapy , Adult , Aged , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Biopsy, Needle , Breast Neoplasms/diagnosis , Breast Neoplasms/pathology , Breast Neoplasms/surgery , Breast Neoplasms, Male/diagnosis , Breast Neoplasms, Male/drug therapy , Combined Modality Therapy , Cyclophosphamide/administration & dosage , Cyclophosphamide/adverse effects , Docetaxel , Drug Administration Schedule , Drug Evaluation , Epirubicin/administration & dosage , Epirubicin/adverse effects , Female , Fluorouracil/administration & dosage , Fluorouracil/adverse effects , Humans , Leukopenia/chemically induced , Lymphatic Metastasis , Male , Mastectomy, Segmental , Middle Aged , Nausea/chemically induced , Taxoids/administration & dosage , Vomiting, Anticipatory/etiologyABSTRACT
PURPOSE: Several articles have reported regression of rectal lymphoma of mucosa-associated lymphoid tissue after anti- Helicobacter pylori therapy. It remains unclear, however, whether lymphoma of rectal mucosa-associated lymphoid tissue is related to Helicobacter pylori infection. METHODS: A 60-year-old woman visited our hospital with a complaint of hematochezia. On colonoscopy a pale, ulcerated protrusion approximately 3.5 cm in diameter was found in the rectum. Pathologic diagnosis of a biopsy specimen was low-grade mucosa-associated lymphoid tissue lymphoma. The patient received a ten-day course of levofloxacin, and the cycle was repeated three times over seven months. RESULTS: Although persistence of Helicobacter pylori infection was confirmed, the tumor regressed completely. CONCLUSION: Our findings in this case suggest that rectal lymphoma of mucosa-associated lymphoid tissue may be related to unknown microorganisms other than Helicobacter pylori. Levofloxacin may be effective for treatment of rectal lymphoma of mucosa-associated lymphoid tissue regardless of Helicobacter pylori infection.
