1.
J Am Chem Soc
; 126(20): 6240-1, 2004 May 26.
Article
in English
| MEDLINE
| ID: mdl-15149215
ABSTRACT
A rhodium-catalyzed asymmetric 1,4-addition reaction has been applied to the synthesis of 2-aryl-4-piperidones. While other conventional nucleophiles fail, organozinc reagents have been successfully utilized for the construction of these useful compounds in very good yield and enantiomeric excess.