ABSTRACT
The leaf essential oil of Filipendula vulgaris, consisting mainly of salicylaldehyde (68.6%), was screened for its antimicrobial activity by the disk diffusion and microdilution broth assays. The essential oil remarkably inhibited the growth of all of the tested bacteria and fungi. It seems that the antimicrobial nature of F. vulgaris essential oil can be attributed to the synergistic interactions of the compounds constituting the oil rather than to the presence of a single inhibitory agent. A synergy in salicylaldehyde/linalool mixtures was observed with a maximum interaction situated in the range between 60:40 and 80:20 (mol ratio). At this concentration range (at a dose of 1.7 microg/disk) no microbial growth was observed while the respective pure compounds, at the corresponding quantities, are shown to be dramatically less active. The MIC value for the 60:40 mixture was determined to be less that 0.009 mg/ml. In addition, an antagonistic relationship between salicylaldehyde and methyl salicylate was established. The maximum (negative) interaction was shown to correspond approximately to the mixture at the 40:60 (methyl salicylate/salicylaldehyde) mol ratio resulting in the complete loss of activity at the investigated dose.
Subject(s)
Aldehydes/antagonists & inhibitors , Anti-Bacterial Agents/pharmacology , Antifungal Agents/pharmacology , Filipendula , Gram-Negative Bacteria/drug effects , Gram-Positive Bacteria/drug effects , Mitosporic Fungi/drug effects , Phytotherapy , Plant Oils/pharmacology , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/therapeutic use , Antifungal Agents/administration & dosage , Antifungal Agents/therapeutic use , Drug Synergism , Humans , Microbial Sensitivity Tests , Plant Leaves , Plant Oils/administration & dosage , Plant Oils/therapeutic useABSTRACT
The authors in their work present a case of the anterior retrosternal diaphragmatic hernia in a 18 months old child which they have successfully operated on after they had discovered it accidentally by a roentgen examination. On that occasion they examined embryology and clinical aspects of this unusual congenital anomaly.
Subject(s)
Hernias, Diaphragmatic, Congenital , Female , Hernia, Diaphragmatic/diagnostic imaging , Hernia, Diaphragmatic/surgery , Humans , Infant , Male , RadiographyABSTRACT
The authors have analysed their experience in treating spleen injuries with children in this institution. From 1970 up to 1988, 22 children were operated upon and splenectomy was done in all the children (5 isolated and 17 united spleen injuries), there were 3 autotransplantations of spleen parts in omentum and 1 case of surgical spleen conservation. Only one operated child died soon after the operation because of a polytrauma and shock. Besides local festering there were not recorded any other cases of infection and sepsis with these and other children operated on within last 25 years. A child's injured spleen should be preserved of course but not at the cost of life, if there are no conditions. A child should be given a chance to live even without the spleen.
Subject(s)
Spleen/injuries , Adolescent , Child , Child, Preschool , Female , Humans , MaleABSTRACT
The authors present a case of a 19 months old baby, twin, with deep burns (45% of the skin), caused by boiling beans. The child was transported to the hospital immediately after the injury. Following the successful anti-shock therapy (whose scheme has been given), the child was operated upon on the VI day: early necrectomy with homotransplantation of his father's skin. In the second stage an autotransplantation (Thiersch) has been performed. The transitory complications were a melaenå appearing on the VII day, and later a contracture of the elbow. Finally, the child left the hospital with no Keloid formations or functional deficit.
