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1.
Pediatr Res ; 32(2): 189-94, 1992 Aug.
Article in English | MEDLINE | ID: mdl-1508608

ABSTRACT

By world standards, the selenium status of the adult population of Christchurch, New Zealand is low. To determine the status of infants undergoing neonatal intensive care, plasma and red cell selenium and glutathione peroxidase levels were measured in infants admitted to the regional neonatal unit. Plasma levels in all newborn infants were one third to one half those in adults. Premature infants had levels significantly lower than those in cord blood from term infants, but their levels were not different from those of term infants admitted to the unit. There were no differences between adult and infant red cell levels. The premature infants remaining in the neonatal unit showed dramatic decreases in plasma selenium and glutathione peroxidase with age, with many infants having selenium levels of less than 0.13 mumol/L (10 micrograms/L). Low levels were seen in infants fed orally as well as those on parenteral nutrition. Thus, the low selenium status of New Zealanders is associated with particularly low selenium levels in premature infants. Because these infants have a high risk for oxidative diseases such as bronchopulmonary dysplasia (chronic lung disease) and retinopathy of prematurity, the possibility that these conditions are more serious in the New Zealand population needs to be assessed and consideration given to dietary supplementation.


Subject(s)
Glutathione Peroxidase/blood , Infant, Premature/blood , Selenium/blood , Adult , Age Factors , Bronchopulmonary Dysplasia/etiology , Diet , Erythrocytes/metabolism , Female , Fetal Blood/metabolism , Humans , Infant , Infant, Newborn , Male , New Zealand , Nutritional Status , Selenium/administration & dosage , Selenium/deficiency
2.
N Z Med J ; 105(932): 139-42, 1992 Apr 22.
Article in English | MEDLINE | ID: mdl-1495647

ABSTRACT

OBJECT: New Zealanders, because of a soil deficiency, have a low intake of selenium. To determine the impact of this on the infant population in Christchurch. METHODS: we have measured red cell and plasma selenium and the selenoenzyme, glutathione peroxidase, in 70 infants less than 12 months old and related these to age and diet. RESULTS: the infant population as a whole had mean plasma levels of selenium and glutathione peroxidase of 33 micrograms/L and 97 U/L compared with adult values of 74 micrograms/L and 150 U/L. Infant red cell levels of 0.30 mu g selenium and 9.0 U glutathione peroxidase per g haemoglobin were similar to those in adults. The selenium status of most breast fed infants after birth remained similar to that of cord blood. Mean plasma selenium and glutathione peroxidase levels in formula fed infants were about half those of breast fed infants, and their red cell selenium was also significantly lower. These did not increase until solids were introduced into the diet. The status of the infants reflected their diet, with the concentration of selenium in formulae being 3.9-5.2 micrograms/mL compared with a mean of 13.4 micrograms/mL in breast milk. CONCLUSIONS: since infants in more replete selenium areas show a gradual rise in blood selenium parameters after birth, this study suggests that formula fed and some breast fed infants in Christchurch receive an inadequate selenium intake. Consideration should be given to supplementing infant formulae and perhaps also the diet of pregnant and/or breast feeding mothers.


Subject(s)
Diet , Infant Food/analysis , Milk, Human/chemistry , Selenium/analysis , Adult , Animals , Erythrocytes/chemistry , Female , Fetal Blood/chemistry , Glutathione Peroxidase/analysis , Glutathione Peroxidase/blood , Humans , Infant , Infant, Newborn , Male , Milk/analysis , New Zealand , Selenium/blood
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