ABSTRACT
BACKGROUND: Chemical peeling using trichloroacetic acid (TCA) is a popular and long utilized procedure in dermatology and cosmetic surgery. OBJECTIVE: To determine the actual concentration of TCA in four disparate methods of preparation of solutions, expressed in the standard pharmaceutical method of weight to volume (wt/vol). METHODS: Method I was wt/vol, method II was weight to weight (wt/wt), method III was grams of TCA added to 100 cc water, and method IV was the usage of saturated TCA, and calling it 100%, then making appropriate dilutions. The amounts of TCA in each solution for methods II, III, and IV were converted, by calculation, to the wt/vol method. RESULTS: The relative concentrations of TCA, ranked by the wt/vol pharmaceutical standard, showed that from strongest to weakest: method IV > method II > method I > method III. CONCLUSIONS: Tremendous variations were found in the relative concentrations of TCA in these solutions. To avoid mishaps and complications, the wt/vol method should be used.
Subject(s)
Chemexfoliation , Trichloroacetic Acid/administration & dosage , Chemistry, Pharmaceutical , Drug Compounding , Humans , Solubility , Solutions/analysis , Solutions/chemical synthesis , Solutions/standards , Trichloroacetic Acid/analysis , Trichloroacetic Acid/chemical synthesis , Trichloroacetic Acid/standards , WaterABSTRACT
A common method of liquid-nitrogen treatment is with the use of the cotton-tipped applicator. Cross-contamination is possible when the applicator is repeatedly dipped into the liquid nitrogen supply. Described is a sterilizable device to hold a small portion of nitrogen sufficient for treatment of a single patient.
Subject(s)
Cross Infection/prevention & control , Cryosurgery/instrumentation , Nitrogen/therapeutic use , Drug Contamination/prevention & control , Equipment Contamination/prevention & control , Equipment Design , Humans , Nitrogen/administration & dosageABSTRACT
Two patients are described, each of whom developed multiple eruptive lesions on sun-exposed areas within days after starting benoxaprofen therapy. The lesions were 2- to 5-mm papules suggestive of syringomas, and microscopically showed squamous metaplasia of eccrine ducts and focal necrosis of eccrine keratinocytes as well as prominent eccrine hyperplasia. In both cases, the lesions resolved completely after benoxaprofen therapy was discontinued. A theoretical basis for these findings is discussed.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Eccrine Glands/pathology , Propionates/adverse effects , Sweat Glands/pathology , Adenoma/pathology , Diagnosis, Differential , Eccrine Glands/drug effects , Female , Humans , Hyperplasia/chemically induced , Metaplasia/chemically induced , Middle Aged , Sunlight , Sweat Gland Neoplasms/pathologyABSTRACT
Hand-Schüller-Christian disease is a disease primarily affecting children, occasionally young adults, and rarely older adults. Very few cases have been reported in individuals past their fifth decade. A review of the English language literature indicates that the onset of Hand-Schüller-Christian disease occurs after the fifth decade in less than 4% of reported cases. A 75-year-old woman's symptoms of Hand-Schüller-Christian disease began in her 76th year, and her cutaneous symptoms were controlled with a topically applied nitrogen mustard.
