ABSTRACT
Chromosomal analysis has become an adjunct in the classification of soft tissue and bone sarcomas and may provide indications of tumor progression. Since it is not always possible or desirable to obtain fresh tumor tissue, the current study analyzed the feasibility to obtain karyotypes from fine needle aspiration biopsies (FNABs) and compared those with karyotypes obtained after short term tissue culture of the corresponding surgical specimens. In 6 of 12 cases an interpretable abnormal karyotype was obtained from the FNABs. These findings demonstrate that it is indeed feasible to obtain karyotypes of primary, metastatic or recurrent sarcomas after a minor procedure such as a FNAB.
Subject(s)
Chromosome Aberrations , Sarcoma/genetics , Adult , Aged , Biopsy, Needle , Child , Female , Humans , Male , Middle Aged , Sarcoma/pathologySubject(s)
Ultrasonography, Prenatal , Urinary Tract/abnormalities , Diagnosis, Differential , Dilatation, Pathologic , Female , Humans , Kidney Pelvis/abnormalities , Male , Polycystic Kidney Diseases/diagnosis , Pregnancy , Sex Factors , Urethral Obstruction/diagnosis , Vesico-Ureteral Reflux/diagnosisSubject(s)
Metrorrhagia/diagnosis , Pregnancy Complications/diagnosis , Ultrasonography , Abortion, Missed/diagnosis , Female , Humans , Metrorrhagia/etiology , Pregnancy , Pregnancy Complications, Neoplastic/diagnosis , Pregnancy Trimester, First , Trophoblastic Neoplasms/diagnosis , Uterine Neoplasms/diagnosis , Uterus/abnormalitiesSubject(s)
Neural Tube Defects/diagnosis , Prenatal Diagnosis , Ultrasonography , Anencephaly/diagnosis , Chromosome Aberrations/diagnosis , Chromosome Disorders , Chromosomes, Human, 13-15 , Encephalocele/diagnosis , Female , Humans , Hydrocephalus/diagnosis , Microcephaly/diagnosis , Pregnancy , Spina Bifida Occulta/diagnosisSubject(s)
Labor, Induced/methods , Prostaglandins E/administration & dosage , Adult , Drug Evaluation , Female , Humans , Parity , PregnancySubject(s)
Bacterial Infections/diagnosis , Pregnancy Complications, Infectious/diagnosis , Urinary Tract Infections/diagnosis , Adolescent , Adult , Anti-Bacterial Agents/therapeutic use , Anti-Infective Agents, Urinary/therapeutic use , Bacterial Infections/drug therapy , Female , Humans , Pregnancy , Urinary Tract Infections/drug therapySubject(s)
Choriocarcinoma/diagnosis , Hydatidiform Mole/diagnosis , Pregnancy Complications/diagnosis , Pregnancy, Multiple , Trophoblastic Neoplasms/diagnosis , Twins , Uterine Neoplasms/diagnosis , Adult , Choriocarcinoma/surgery , Female , Humans , Hydatidiform Mole/surgery , Pregnancy , Trophoblastic Neoplasms/surgeryABSTRACT
The effects on blood-clotting factors, plasma lipids and endometrial proliferation of two types of oral oestrogen therapy (a) cyclical therapy with 0.625 mg/day conjugated equine oestrogens for 3 wk followed by 1 wk without treatment, and (b) continuous therapy with 2 mg/day oestriol) were investigated in a 5-mth study involving 22 post-menopausal women. Assays were performed in order to measure blood-clotting factors (activity of the factor II-VII-X complex, anti-thrombin III, euglobulin lysis time) and plasma lipids (total cholesterol, triglycerides, lipoprotein electrophoresis) before treatment and after 3 and 4 mth of treatment. The only significant change found to have occurred was a decrease in the beta: alpha lipoproteins ratio; this was greater in the group treated with conjugated equine oestrogens, but was also statistically significant in the group treated with oestriol. Endometrial proliferation was investigated indirectly by means of the medroxyprogesterone acetate (MPA) test before treatment and after 5 mth of treatment. The response to MPA at the end of 5 mth of treatment in patients previously unresponsive, showed endometrial proliferation to have occurred during treatment with conjugated equine oestrogens but not during treatment with oestriol.
Subject(s)
Blood Coagulation/drug effects , Endometrium/drug effects , Estriol/pharmacology , Lipids/blood , Menopause/drug effects , Blood Coagulation Factors/analysis , Cholesterol/blood , Clinical Trials as Topic , Estrogens, Conjugated (USP) , Female , Follicle Stimulating Hormone/blood , Humans , Lipoproteins/blood , Middle Aged , Random Allocation , Triglycerides/bloodSubject(s)
Adrenal Glands/enzymology , Adrenal Hyperplasia, Congenital/diagnosis , Adrenocortical Hyperfunction/diagnosis , Androgens/metabolism , Mixed Function Oxygenases/deficiency , Adrenal Glands/pathology , Adrenal Hyperplasia, Congenital/enzymology , Adrenocortical Hyperfunction/enzymology , Adult , Dexamethasone/pharmacology , Female , Humans , Hyperplasia , Steroids/metabolismSubject(s)
Bilirubin/blood , Infant, Newborn , Adult , Age Factors , Cesarean Section , Delivery, Obstetric , Female , Humans , Labor, Induced , Maternal Age , Oxytocics/pharmacology , Pregnancy , Prostaglandins, Synthetic/pharmacologySubject(s)
Hemorrhage/prevention & control , Iliac Artery/surgery , Ligation/instrumentation , Adult , Aged , Female , Genital Diseases, Female/surgery , Humans , Middle AgedSubject(s)
Bilirubin/blood , Infant, Newborn , Adult , Female , Humans , Labor, Induced , Oxytocin/pharmacology , Pregnancy , Prostaglandins F/pharmacologySubject(s)
Pregnancy Complications/surgery , Uterus/abnormalities , Adolescent , Adult , Female , Humans , Pregnancy , Uterus/surgeryABSTRACT
A case of trophoblastic disease in a twin pregnancy is described from its diagnosis to follow-up after emptying of the uterine cavity. The possible causes of trophoblastic disease are discussed.
Subject(s)
Trophoblastic Neoplasms/pathology , Adult , Edema/drug therapy , Female , Fetus , Furosemide/therapeutic use , Humans , Hypothyroidism/diagnosis , Placenta/pathology , Pregnancy , Thyroglobulin/therapeutic use , Twins , Uterus/pathologyABSTRACT
The influence of various maternal and neonatal factors on blood bilirubin is examined. An increase in neonatal values may be due to the relatively advanced age of the mother, whereas neonatal age, sex and weight, increase in maternal weight during pregnancy, and maternal body surface area would appear to be without influence.
