[Cytogenetic activity of testosterone propionate and methyltestosterone in a culture of lymphocytes of healthy women and women suffering from hyperandrogenism]. / Tsitogeneticheskaia aktivnost' testosteron-propionata i metiltestosterona v kul'tury limfotsitov zdorovykh zhenshchin i zhenshchin, stradaiushchikh hiperandrogeniei.

To discover the effects of various concentrations of androgenic preparations on lymphocyte cultures from healthy women (group 1) and of women with hyperandrogenism (group 2), a total of 6792 metaphases were examined after peripheral blood lymphocyte culturing after Hangerford. The data indicated a relatively high incidence of aberrant metaphases, total number of ruptures and paired ruptures in the second group, a higher cytogenetic activity of testosterone propionate in both groups, and a higher cytogenetic activity of androgenic hormones in the second group. Bearing in mind a similar, if not higher, activity of endogenic testosterone in a female organism, we must admit a high probability of genetic system involvement in women suffering from hyperandrogenism.

[Role of monoamines in the pathogenesis of various forms of endocrine sterility]. / Uchastie monoaminov v patogeneze nekotorykh form éndokrinnogo besplodiia.

No doubt, the problems of pathogenesis of different types of endocrine sterility are of practical interest. Biogenic amines (dopamine, norepinephrine and serotonin) play a decisive role in the hypothalamic regulation of the sexual cycle, in the regulation of secretion and production of hypothalamic neurohormones. Disorder of the monoaminergic regulation may lie at the basis of reproductive dysfunction. A total of 40 women with hyperprolactinemia, 44 with a hyperandrogenic sterility, 40 with chronic anovulation of obscure genesis, and 20 healthy women of reproductive age (controls) were investigated. The following diagnostic methods were used: echography of the uterus and appendages, x-ray of the cranial bones, laparoscopy, determination of blood levels of FSH, LH, PRL, estradiol, progesterone, testosterone, cortisol in the follicular and luteal phases of the menstrual cycle; determination of urinary levels of dopamine, adrenalin and norepinephrine, and blood levels of serotonin. The results have shown that hyperprolactinemia and hyperandrogenemia are accompanied by disorder of monoaminergic regulation, resulting in the rearrangement of hormonal interrelationships in the neuroendocrine system.

[Diagnostic criteria for polycystic ovary syndrome]. / Diagnosticheskie kriterii sindroma polikistoznykh iaichnikov.

Due to the comprehensive examination of 50 patients with ovarian polycystosis the authors suggested that ultrasound, laparoscopic, hormonal and endometrial parameters should be employed as diagnostic criteria.

Practical guidelines for the treatment of infertility in hirsute women.

On the basis of retrospective investigation of 315 infertile hirsute women aged between 19 and 35 years, it was attempted to find selection criteria for infertility treatment. Cases with adrenal, ovarian and pituitary tumors, congenital adrenal hyperplasia and genetic disorders should be excluded by means of preliminary investigations. It is possible to select the optimal treatment for each individual patient using a flow-chart. Thanks to this approach, a pregnancy rate of 83% is achieved.