A prospective study of C-reactive protein as a state marker in Cardiac Syndrome X.

Cardiac Syndrome X (CSX), the presence of angina pectoris despite normal epicardial coronary arteries seen on invasive angiography, is known to be associated with an elevation of several inflammatory biomarkers, suggesting a possible role for inflammation in its pathogenesis. We sought to establish if C-reactive protein (CRP) levels varied with disease severity and so whether it is a state or trait marker. We studied 16 CSX patients with typical angina pectoris, normal coronary arteries and an electrically positive exercise stress test (EST) and 13 age- and sex-matched healthy controls (HC). CSX patients were followed up at a subsequent visit with repeated exercise stress testing and CRP measurement. We found that CRP levels were significantly higher in the CSX group compared to the HC (1.5 [0.8-4.5] v 0.8 [0.4-1.4] mg/L, p=0.02). This elevation in CRP persisted throughout the study length. CRP correlated with time to symptoms on EST at enrolment and at the second visit (r=-0.690, df=10, p=0.013 and r=-0.899, df=4, p=0.015, respectively). At the follow-up visit, 50% of CSX patients developed electrically and symptomatically negative ESTs. The mean CRP of this group was significantly lower than that of the CSX patients with ongoing symptoms and positive ESTs (1.2±0.2 v 2.8±0.6mg/L, p=0.018) and did not differ significantly from that of healthy controls. CRP levels also dropped in patients whose symptoms improved while they increased in patients who became more symptomatic (p=0.027). We conclude that the results of this small study support the concept of CSX being an inflammatory-mediated condition with CRP levels prospectively varying with functional measures of disease severity. This indicates that CRP is a state marker in CSX.

Enhancing back-up support during difficult coronary stent delivery: single-center case series of experience with the Heartrail II catheter.

BACKGROUND: Despite continued advances in creating lower-profile intracoronary balloons and stents, technical difficulties with stent deliverability are frequently encountered. Recent advances in catheter design have yielded soft ended atraumatic catheters for use within standard guide catheters - the so called double coaxial guiding catheter technique. We report our preliminary experience using the 5 Fr Terumo guide catheter (Heartrail II, Terumo) from a single center. METHODS: We describe six percutaneous coronary intervention (PCI) procedures where stent deployment initially failed during the standard approach. Subsequent utilization of this 5 Fr catheter system within a standard 6 Fr guide facilitated successful procedural outcomes. This catheter system facilitated non-traumatic deep intubation and stent delivery beyond the site of obstruction encountered during PCI of the distal right coronary and left anterior descending arteries. RESULTS: 3 males and 3 females with a mean age of 72.5 ± 5.4 years underwent PCI using the Heartrail II catheter. Patient and procedural characteristics are summarized in Table 1. The intracoronary catheter was inserted into 3 right coronary arteries, 2 left circumflex arteries and 1 left anterior descending artery. Classification of discrete lesions yielded 6 type C lesions. The mean number of stents deployed was 3.33 ± 0.80 with a mean procedure X-ray screening duration of 35.04 ± 7.79 minutes. No complications relating to ostial artery catheter-induced dissections were encountered.