1.
Clin Pharmacol Ther
; 17(1): 57-65, 1975 Jan.
Article
in English
| MEDLINE
| ID: mdl-1122670
ABSTRACT
6-N-Hydroxylaminopurine riboside (HAPR) was studied in man because of its therapeutic activity in several transplanted animal neoplasms. It was not cross-resistant to other antimetabolites useful in the treatment of human neoplasia. HAPR produced marked hemolytic anemia at doses far below those that might have produced any cytotoxic or therapeutic effect. There was evidence of hemolysis at total doses as low as 0.5 mg/kg given intravenously. For man, HAPR is one of the most active hemolytic drugs.
Subject(s)
Adenosine/analogs & derivatives , Hemolysis/drug effects , Hydroxylamines/blood , Adenosine/blood , Adenosine/therapeutic use , Adult , Bilirubin/analysis , Blood Cell Count , Breast Neoplasms/drug therapy , Dipyridamole/therapeutic use , Erythrocytes/drug effects , Female , Hemoglobins/analysis , Humans , Hydroxylamines/administration & dosage , Hydroxylamines/analysis , Hydroxylamines/therapeutic use , Male , Melanoma/drug therapy , Middle Aged , Neoplasm Metastasis , Neoplasms/drug therapy , Purines/administration & dosage , Rectal Neoplasms/drug therapy , Reticulocytes , Time Factors
2.
West J Med
; 120(5): 412-5, 1974 May.
Article
in English
| MEDLINE
| ID: mdl-4839488
3.
JAMA
; 221(3): 261-3, 1972 Jul 17.
Article
in English
| MEDLINE
| ID: mdl-5067790
Subject(s)
Hodgkin Disease/drug therapy , Adolescent , Adult , Aged , Anemia/chemically induced , Biopsy , Female , Hodgkin Disease/diagnosis , Hodgkin Disease/radiotherapy , Humans , Male , Mechlorethamine/administration & dosage , Mechlorethamine/adverse effects , Mechlorethamine/therapeutic use , Middle Aged , Prednisone/administration & dosage , Prednisone/therapeutic use , Private Practice , Procarbazine/therapeutic use , Remission, Spontaneous , Time Factors , Vincristine/administration & dosage , Vincristine/therapeutic use
4.
CA Cancer J Clin
; 22(3): 138-47, 1972.
Article
in English
| MEDLINE
| ID: mdl-4625563
5.
JAMA
; 220(5): 714-6, 1972 May 01.
Article
in English
| MEDLINE
| ID: mdl-5067147
6.
Am Fam Physician
; 3(6): 73-84, 1971 Jun.
Article
in English
| MEDLINE
| ID: mdl-4325596
Subject(s)
Neoplasms/drug therapy , Blood Cell Count , Breast Neoplasms/drug therapy , Carcinoma, Squamous Cell/drug therapy , Child , Choriocarcinoma/drug therapy , Colonic Neoplasms/drug therapy , Endometrium , Female , Head and Neck Neoplasms/drug therapy , Hodgkin Disease/drug therapy , Humans , Leukemia, Lymphoid/drug therapy , Leukemia, Myeloid, Acute/drug therapy , Lung Neoplasms/drug therapy , Lymphoma, Large B-Cell, Diffuse/drug therapy , Lymphoma, Non-Hodgkin/drug therapy , Male , Melanoma/drug therapy , Multiple Myeloma/drug therapy , Mycosis Fungoides/drug therapy , Neoplasm Metastasis , Ovarian Neoplasms/drug therapy , Pregnancy , Prostatic Neoplasms/drug therapy , Testicular Neoplasms/drug therapy , Uterine Cervical Neoplasms/drug therapy , Wilms Tumor/drug therapy
7.
Am J Clin Pathol
; 51(5): 555-8, 1969 May.
Article
in English
| MEDLINE
| ID: mdl-5779402
8.
Lymphology
; 2(1): 7-15, 1969 Mar.
Article
in English
| MEDLINE
| ID: mdl-5772226
Subject(s)
Lymph Nodes , Plasmacytoma/diagnosis , Aged , Blood Protein Electrophoresis , Humans , Lymph Nodes/pathology , Male , Neck , Plasmacytoma/pathology
9.
Am J Obstet Gynecol
; 101(2): 267-8, 1968 May 15.
Article
in English
| MEDLINE
| ID: mdl-5652963
10.
J Med Chem
; 11(3): 521-3, 1968 May.
Article
in English
| MEDLINE
| ID: mdl-5656490
Subject(s)
Hydroxylamines , Purines , Aminohydrolases/antagonists & inhibitors , Animals , Hydroxylamines/chemical synthesis , Hydroxylamines/therapeutic use , Leukemia L1210/drug therapy , Mercaptopurine/therapeutic use , Mice , Nucleosides , Purines/chemical synthesis , Purines/therapeutic use , Spectrum Analysis , Ultraviolet Rays
11.
Arch Intern Med
; 120(5): 575-80, 1967 Nov.
Article
in English
| MEDLINE
| ID: mdl-4293348
12.
Gastroenterology
; 52(5): 875-81, 1967 May.
Article
in English
| MEDLINE
| ID: mdl-6024890
Subject(s)
Hyperbilirubinemia, Hereditary , Jaundice, Chronic Idiopathic , Adolescent , Anemia, Hemolytic/etiology , Child , Female , Humans , Liver Function Tests , Male , Middle Aged
13.
Am J Dig Dis
; 12(4): 413-7, 1967 Apr.
Article
in English
| MEDLINE
| ID: mdl-6020628
14.
Biochem Pharmacol
; 16(4): 689-706, 1967 Apr.
Article
in English
| MEDLINE
| ID: mdl-6033789
Subject(s)
Culture Techniques , Cytarabine/metabolism , Cytarabine/pharmacology , Cytosine Nucleotides/pharmacology , Leukemia L1210/metabolism , Lymphoma/metabolism , Nucleosides/pharmacology , Thymidine/pharmacology , Animals , Burkitt Lymphoma/metabolism , Chromatography, Paper , Drug Antagonism , Drug Synergism , Kidney/metabolism , Liver/metabolism , Mice , Oxidation-Reduction , Uracil Nucleotides/pharmacology
15.
Ann Intern Med
; 66(2): 249-57, 1967 Feb.
Article
in English
| MEDLINE
| ID: mdl-6016539
16.
Surg Gynecol Obstet
; 122(6): 1335-47, 1966 Jun.
Article
in English
| MEDLINE
| ID: mdl-5328839
17.
Am J Surg
; 111(5): 651-5, 1966 May.
Article
in English
| MEDLINE
| ID: mdl-5295963
Subject(s)
Gastrointestinal Hemorrhage/therapy , Hypothermia, Induced , Adult , Aged , Duodenal Ulcer/complications , Esophageal and Gastric Varices/therapy , Female , Gastritis/complications , Gastrointestinal Hemorrhage/prevention & control , Humans , Liver Cirrhosis/complications , Male , Middle Aged , Peptic Ulcer Hemorrhage/therapy , Stomach
18.
Yale J Biol Med
; 38(5): 449-55, 1966 Apr.
Article
in English
| MEDLINE
| ID: mdl-5957373
19.
JAMA
; 195(4): 316-9, 1966 Jan 24.
Article
in English
| MEDLINE
| ID: mdl-5951822