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1.
Hemolysis induced by 6-N-hydroxylaminopurine riboside, an adenosine analogue.
Dollinger, M R; Krakoff, I H.
Clin Pharmacol Ther ; 17(1): 57-65, 1975 Jan.
Article in English | MEDLINE | ID: mdl-1122670

ABSTRACT

6-N-Hydroxylaminopurine riboside (HAPR) was studied in man because of its therapeutic activity in several transplanted animal neoplasms. It was not cross-resistant to other antimetabolites useful in the treatment of human neoplasia. HAPR produced marked hemolytic anemia at doses far below those that might have produced any cytotoxic or therapeutic effect. There was evidence of hemolysis at total doses as low as 0.5 mg/kg given intravenously. For man, HAPR is one of the most active hemolytic drugs.


Subject(s)
Adenosine/analogs & derivatives , Hemolysis/drug effects , Hydroxylamines/blood , Adenosine/blood , Adenosine/therapeutic use , Adult , Bilirubin/analysis , Blood Cell Count , Breast Neoplasms/drug therapy , Dipyridamole/therapeutic use , Erythrocytes/drug effects , Female , Hemoglobins/analysis , Humans , Hydroxylamines/administration & dosage , Hydroxylamines/analysis , Hydroxylamines/therapeutic use , Male , Melanoma/drug therapy , Middle Aged , Neoplasm Metastasis , Neoplasms/drug therapy , Purines/administration & dosage , Rectal Neoplasms/drug therapy , Reticulocytes , Time Factors
2.
Tricuspid valve replacement in carcinoid heart disease.
Lund, H G; Cleveland, R J; Greenberg, L H; Lippmann, M; Dollinger, M R.
West J Med ; 120(5): 412-5, 1974 May.
Article in English | MEDLINE | ID: mdl-4839488

Subject(s)
Malignant Carcinoid Syndrome/complications , Tricuspid Valve Insufficiency/surgery , Humans , Male , Middle Aged , Tricuspid Valve Insufficiency/etiology
3.
Combination chemotherapy of Hodgkin's disease in private practice.
Greenberg, L H; Wong, S; Richardson, A P; Dollinger, M R.
JAMA ; 221(3): 261-3, 1972 Jul 17.
Article in English | MEDLINE | ID: mdl-5067790

Subject(s)
Hodgkin Disease/drug therapy , Adolescent , Adult , Aged , Anemia/chemically induced , Biopsy , Female , Hodgkin Disease/diagnosis , Hodgkin Disease/radiotherapy , Humans , Male , Mechlorethamine/administration & dosage , Mechlorethamine/adverse effects , Mechlorethamine/therapeutic use , Middle Aged , Prednisone/administration & dosage , Prednisone/therapeutic use , Private Practice , Procarbazine/therapeutic use , Remission, Spontaneous , Time Factors , Vincristine/administration & dosage , Vincristine/therapeutic use
4.
Management of recurrent malignant effusions.
Dollinger, M R.
CA Cancer J Clin ; 22(3): 138-47, 1972.
Article in English | MEDLINE | ID: mdl-4625563

Subject(s)
Antineoplastic Agents/therapeutic use , Ascites/drug therapy , Neoplasms/complications , Pleural Effusion/drug therapy , Ascites/etiology , Ascites/surgery , Humans , Radiotherapy , Recurrence
5.
A novel program of continuing medical education.
Dollinger, M R; Korenman, S G; Solomon, D H; Brayton, D F.
JAMA ; 220(5): 714-6, 1972 May 01.
Article in English | MEDLINE | ID: mdl-5067147

Subject(s)
Education, Medical, Continuing , Internal Medicine/education , California , Educational Measurement , Hospitals, General , Humans
6.
How to use cancer chemotherapy.
Dollinger, M R.
Am Fam Physician ; 3(6): 73-84, 1971 Jun.
Article in English | MEDLINE | ID: mdl-4325596

Subject(s)
Neoplasms/drug therapy , Blood Cell Count , Breast Neoplasms/drug therapy , Carcinoma, Squamous Cell/drug therapy , Child , Choriocarcinoma/drug therapy , Colonic Neoplasms/drug therapy , Endometrium , Female , Head and Neck Neoplasms/drug therapy , Hodgkin Disease/drug therapy , Humans , Leukemia, Lymphoid/drug therapy , Leukemia, Myeloid, Acute/drug therapy , Lung Neoplasms/drug therapy , Lymphoma, Large B-Cell, Diffuse/drug therapy , Lymphoma, Non-Hodgkin/drug therapy , Male , Melanoma/drug therapy , Multiple Myeloma/drug therapy , Mycosis Fungoides/drug therapy , Neoplasm Metastasis , Ovarian Neoplasms/drug therapy , Pregnancy , Prostatic Neoplasms/drug therapy , Testicular Neoplasms/drug therapy , Uterine Cervical Neoplasms/drug therapy , Wilms Tumor/drug therapy
7.
Effect of 5-dydroxyindolylacetic acid in the colorimetric determination of urinary vanilmandelic acid.
Fleisher, M; Dollinger, M R; Schwartz, M K.
Am J Clin Pathol ; 51(5): 555-8, 1969 May.
Article in English | MEDLINE | ID: mdl-5779402

Subject(s)
Colorimetry , Hydroxyindoleacetic Acid/urine , Malignant Carcinoid Syndrome/urine , Mandelic Acids/urine , Humans , Hydroxyindoleacetic Acid/pharmacology , Male , Methods , Middle Aged , Vanilmandelic Acid/urine
8.
Primary plasmacytoma of lymph nodes.
Gaston, E A; Dollinger, M R; Strong, E W; Hajdu, S I.
Lymphology ; 2(1): 7-15, 1969 Mar.
Article in English | MEDLINE | ID: mdl-5772226

Subject(s)
Lymph Nodes , Plasmacytoma/diagnosis , Aged , Blood Protein Electrophoresis , Humans , Lymph Nodes/pathology , Male , Neck , Plasmacytoma/pathology
9.
Response to actinomycin D of malignant carcinoid arising in an ovarian teratoma.
Koven, B J; Dollinger, M R; Nadel, M S.
Am J Obstet Gynecol ; 101(2): 267-8, 1968 May 15.
Article in English | MEDLINE | ID: mdl-5652963

Subject(s)
Dactinomycin/therapeutic use , Malignant Carcinoid Syndrome/pathology , Ovarian Neoplasms/drug therapy , Teratoma/drug therapy , Adult , Female , Humans , Lung/diagnostic imaging , Lung/pathology , Neoplasm Metastasis , Radiography
10.
The synthesis and biological properties of hydroxylaminopurines and related derivatives.
Giner-Sorolla, A; O'Bryant, S A; Nanos, C; Dollinger, M R; Bendich, A; Burchenal, J H.
J Med Chem ; 11(3): 521-3, 1968 May.
Article in English | MEDLINE | ID: mdl-5656490

Subject(s)
Hydroxylamines , Purines , Aminohydrolases/antagonists & inhibitors , Animals , Hydroxylamines/chemical synthesis , Hydroxylamines/therapeutic use , Leukemia L1210/drug therapy , Mercaptopurine/therapeutic use , Mice , Nucleosides , Purines/chemical synthesis , Purines/therapeutic use , Spectrum Analysis , Ultraviolet Rays
11.
Carcinoid syndrome associated with pancreatic tumors.
Dollinger, M R; Ratner, L H; Shamoian, C A; Blackbourne, B D.
Arch Intern Med ; 120(5): 575-80, 1967 Nov.
Article in English | MEDLINE | ID: mdl-4293348

Subject(s)
Adenoma, Islet Cell/complications , Liver Neoplasms/complications , Malignant Carcinoid Syndrome/complications , Pancreatic Neoplasms/complications , Female , Humans , Middle Aged , Neoplasm Metastasis
12.
Chronic familial hyperbilirubinemia. Hepatic defect(s) associated with occult hemolysis.
Dollinger, M R; Brandborg, L L; Sartor, V E; Bernstein, J M.
Gastroenterology ; 52(5): 875-81, 1967 May.
Article in English | MEDLINE | ID: mdl-6024890

Subject(s)
Hyperbilirubinemia, Hereditary , Jaundice, Chronic Idiopathic , Adolescent , Anemia, Hemolytic/etiology , Child , Female , Humans , Liver Function Tests , Male , Middle Aged
13.
Late elevation in serum bromsulfalein in Dubin-Johnson syndrome. A comparative case study.
Dollinger, M R; Brandborg, L L.
Am J Dig Dis ; 12(4): 413-7, 1967 Apr.
Article in English | MEDLINE | ID: mdl-6020628

Subject(s)
Hepatitis A/diagnosis , Hepatitis/diagnosis , Jaundice, Chronic Idiopathic/blood , Jaundice/diagnosis , Sulfobromophthalein/blood , Diagnosis, Differential , Humans , Jaundice, Chronic Idiopathic/pathology , Male , Middle Aged , Sulfobromophthalein/urine
14.
Analogs of 1-beta-D-arabinofuranosylcytosine. Studies on mechanisms of action in Burkitt's cell culture and mouse leukemia, and in vitro deamination studies.
Dollinger, M R; Burchenal, J H; Kreis, W; Fox, J J.
Biochem Pharmacol ; 16(4): 689-706, 1967 Apr.
Article in English | MEDLINE | ID: mdl-6033789

Subject(s)
Culture Techniques , Cytarabine/metabolism , Cytarabine/pharmacology , Cytosine Nucleotides/pharmacology , Leukemia L1210/metabolism , Lymphoma/metabolism , Nucleosides/pharmacology , Thymidine/pharmacology , Animals , Burkitt Lymphoma/metabolism , Chromatography, Paper , Drug Antagonism , Drug Synergism , Kidney/metabolism , Liver/metabolism , Mice , Oxidation-Reduction , Uracil Nucleotides/pharmacology
15.
Quinacrine (Atabrine) in the treatment of neoplastic effusions.
Dollinger, M R; Krakoff, I H; Karnofsky, D A.
Ann Intern Med ; 66(2): 249-57, 1967 Feb.
Article in English | MEDLINE | ID: mdl-6016539

Subject(s)
Exudates and Transudates/drug therapy , Neoplasms/complications , Peritoneal Diseases , Pleural Effusion/drug therapy , Quinacrine/therapeutic use , Adult , Aged , Female , Humans , Male , Middle Aged
16.
Newer aspects of the carcinoid spectrum.
Dollinger, M R; Gardner, B.
Surg Gynecol Obstet ; 122(6): 1335-47, 1966 Jun.
Article in English | MEDLINE | ID: mdl-5328839

Subject(s)
Malignant Carcinoid Syndrome , Humans , In Vitro Techniques
17.
Local cooling in the management of acute upper gastrointestinal bleeding.
Dollinger, M R; Morgan, L R.
Am J Surg ; 111(5): 651-5, 1966 May.
Article in English | MEDLINE | ID: mdl-5295963

Subject(s)
Gastrointestinal Hemorrhage/therapy , Hypothermia, Induced , Adult , Aged , Duodenal Ulcer/complications , Esophageal and Gastric Varices/therapy , Female , Gastritis/complications , Gastrointestinal Hemorrhage/prevention & control , Humans , Liver Cirrhosis/complications , Male , Middle Aged , Peptic Ulcer Hemorrhage/therapy , Stomach
18.
Kaposi's sarcoma and coexistent giant follicular lymphoblastoma.
Dollinger, M R; Foye, L V.
Yale J Biol Med ; 38(5): 449-55, 1966 Apr.
Article in English | MEDLINE | ID: mdl-5957373

Subject(s)
Lymphoma/complications , Sarcoma, Kaposi/complications , Chlorambucil/therapeutic use , Humans , Lymphoma/drug therapy , Male , Middle Aged , Nitrogen Mustard Compounds/therapeutic use , Sarcoma, Kaposi/drug therapy
19.
Myocardial infarction due to postirradiation fibrosis of the coronary arteries. Case of successfully treated Hodgkin's disease with lower esophageal involvement.
Dollinger, M R; Lavine, D M; Foye, L V.
JAMA ; 195(4): 316-9, 1966 Jan 24.
Article in English | MEDLINE | ID: mdl-5951822

Subject(s)
Coronary Disease/etiology , Hodgkin Disease/radiotherapy , Myocardial Infarction/etiology , Radiotherapy/adverse effects , Adult , Bronchopneumonia/etiology , Esophageal Stenosis/pathology , Humans , Lung Neoplasms/radiotherapy , Male
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