ABSTRACT
In response to the syngeneic carcinoma cells the regional lymph nodes are enlarged, but their lymphatic Mast Cell content was reduced in both, relative and absolute terms. This result confirms our earlier data on the depletion of lymphatic Mast Cells in the lymph nodes stimulated by various antigens.
Subject(s)
Carcinoma/immunology , Lymph Nodes/immunology , Lymphocytes/immunology , Mast Cells/immunology , Animals , Cell Line , Crosses, Genetic , Leukemia L1210/immunology , Lymphocyte Transfusion , Mice , Mice, Inbred Strains , Transplantation, IsogeneicABSTRACT
Inoculation of Moloney murine sarcoma virus (M-MSV) into shank muscles of adult NMRI mice resulted in localized sarcoma and periosteal membrane proliferation with subsequent periosteal bone formation. Newly formed bone arose from outer surface of shank bones. Two weeks after M-MSV inoculation the width of bone cortex increased nearly 4 times. The spaces between newly formed bone ossicles were filled with bone marrow. In the later stages these bone marrow cavities were merged with medullar cavities. No extraskeletal bone formation was observed. The regression of M-MSV-induced sarcomas coincides with cessation of the proliferation of bone therefore allowing the maturation and rebuilding of bone. Newly formed bone was not resorbed during a 6-month observation period.
