ABSTRACT
A 5-year-old child presented with an unresectable liver neoplasm, the histology of which resembled a malignant rhabdoid tumor. Clinical course was unrelenting despite therapy, and the child died four months later. During the course of her illness, she developed watery diarrhea and was found to have a high serum level of vasointestinal peptide (VIP). This is the first report of a childhood tumor with rhabdoid features to secrete VIP.
Subject(s)
Liver Neoplasms/metabolism , Rhabdoid Tumor/metabolism , Vasoactive Intestinal Peptide/metabolism , Child, Preschool , Fatal Outcome , Female , Humans , Liver Neoplasms/blood , Rhabdoid Tumor/blood , Vasoactive Intestinal Peptide/bloodABSTRACT
Saphenous vein patch angioplasty has been used to improve the results of carotid endarterectomy by decreasing the incidence of postoperative occlusion and recurrent stenosis. A rare but potentially lethal complication of this technique is aseptic necrosis and rupture of the vein patch during the postoperative period. We report three cases of this phenomenon and review an additional 13 cases from the literature. This event generally occurs without warning 2 to 7 days postoperatively and may result in death or stroke. At reoperation, the central portion of the vein patch is necrotic, without evidence of infection. Technical considerations in the harvesting and preparation of these grafts are reviewed, as are the physical parameters predisposing certain vein patches to rupture. Saphenous vein harvested from the ankle has been linked to every reported case. Small diameter veins in particular appear to carry a higher risk of rupture.
Subject(s)
Carotid Stenosis/surgery , Endarterectomy, Carotid/methods , Intracranial Arteriosclerosis/surgery , Postoperative Complications/surgery , Saphenous Vein/transplantation , Surgical Wound Dehiscence/surgery , Aged , Carotid Stenosis/pathology , Female , Humans , Intracranial Arteriosclerosis/pathology , Male , Necrosis , Postoperative Complications/pathology , Rupture, Spontaneous , Saphenous Vein/pathology , Surgical Wound Dehiscence/pathologySubject(s)
Cystic Adenomatoid Malformation of Lung, Congenital/diagnostic imaging , Pulmonary Emphysema/congenital , Ultrasonography, Prenatal , Adult , Cystic Adenomatoid Malformation of Lung, Congenital/complications , Cystic Adenomatoid Malformation of Lung, Congenital/drug therapy , Female , Humans , Indomethacin/therapeutic use , Infant, Newborn , Male , Pregnancy , Prognosis , Pulmonary Emphysema/complications , Pulmonary Emphysema/diagnostic imagingSubject(s)
Leukemia-Lymphoma, Adult T-Cell/pathology , Synovial Membrane/pathology , Adult , Blotting, Southern , Flow Cytometry , Humans , Immunohistochemistry , Joint Diseases/pathology , Leukemia-Lymphoma, Adult T-Cell/blood , Lymph Nodes/pathology , Male , Polymerase Chain Reaction , T-Lymphocyte Subsets/pathology , Wrist Joint/pathologyABSTRACT
From a group of 520 spinal cord injury patients treated at Rancho Los Amigos Hospital, two cases of progressive myelopathy secondary to cystic degeneration of the spinal cord have been identified. The cyst may dissect proximately to produce progressive neurologic deficit. Surgical treatment with shunting can allow stabilization and improvement with return of newly lost function.
Subject(s)
Cysts/pathology , Nerve Degeneration , Spinal Cord Injuries/pathology , Adult , Cysts/surgery , Female , Fractures, Open/pathology , Humans , Male , Paralysis/pathology , Spinal Cord/pathology , Spinal Cord Injuries/surgery , Thoracic Vertebrae/injuriesABSTRACT
Somatic, endocrine and behavioral correlates of growth were measured in intact and hypophysectomized adult hamsters with or without electrolytic damage to the rostral septal area. Septal (SEP) lesions significantly increased somatic growth rate, food consumption and serum concentration of growth hormone (GH) and insulin. Pituitary GH content and concentration were reduced in lesioned hamsters. None of these changes were found in hypophysectomized hamsters with SEP lesions. SEP lesions did not affect the percentage of body fat. These data suggest that the septum or adjacent fibers of passage inhibit growth in adult hamsters.
