ABSTRACT
OBJECTIVE: To present a protocol for the administration and development technique of the desensitization regimens for cotrimoxazole, rifampicin and penicillin G hypersensibility. METHOD: A review of the available desensitization protocols for these antibiotics and a retrospective study of desensitization processes undertaken in the center from 1998. A development technique of the antibiotic dosages was designed. RESULTS: Desensitization regimens for cotrimoxazole, rifampicin and penicillin G undertaken in the center in 9 patients came from a protocol by Glucksteins et al., Holland et al. and Wendal et al., respectively. After the literature review and the satisfactory results that allowed subsequent antibiotic administration in the 9 cases, these regimens were established as protocols of the center. CONCLUSIONS: Dosage development and patient administration have a practical application and can help to decrease the potential mistakes related to the complexity of the process.
Subject(s)
Anti-Infective Agents/adverse effects , Desensitization, Immunologic , Drug Hypersensitivity/therapy , Penicillin G/adverse effects , Rifampin/immunology , Trimethoprim, Sulfamethoxazole Drug Combination/adverse effects , Anti-Infective Agents/immunology , Drug Hypersensitivity/etiology , Humans , Penicillin G/immunology , Retrospective Studies , Rifampin/adverse effects , Trimethoprim, Sulfamethoxazole Drug Combination/immunologyABSTRACT
Objetivo: Protocolizar la administración y la técnica de elaboraciónde las pautas de desensibilización de cotrimoxazol, rifampicinay penicilina G.Método: Búsqueda bibliográfica en MEDLINE de los protocolosdisponibles y estudio retrospectivo de las desensibilizacionesaplicadas en el centro desde 1998. Diseño gráfico de la elaboraciónde las tomas de cada antibiótico.Resultados: Se ha realizado un total de 9 desensibilizacionesde cotrimoxazol, rifampicina y penicilina G siguiendo el protocolode Glucksteins y cols., Holland y cols. y Wendal y cols., respectivamente,permitiendo la readministración del antibiótico en todoslos casos. Los resultados tanto obtenidos en el centro como publicadosen la literatura y la no existencia de nuevos protocolos queaporten una mayor evidencia confirman la idoneidad de los protocolosaplicados.Conclusiones: La elaboración y administración al paciente delos protocolos seleccionados presentan una aplicación prácticaque permite disminuir los posibles errores derivados de la complejidaddel proceso
Objective: To present a protocol for the administration anddevelopment technique of the desensitization regimens for cotrimoxazole,rifampicin and penicillin G hypersensibility.Method: A review of the available desensitization protocolsfor these antibiotics and a retrospective study of desensitizationprocesses undertaken in the center from 1998. A developmenttechnique of the antibiotic dosages was designed.Results: Desensitization regimens for cotrimoxazole,rifampicin and penicillin G undertaken in the center in 9 patientscame from a protocol by Glucksteins et al., Holland et al. andWendal et al., respectively. After the literature review and the satisfactoryresults that allowed subsequent antibiotic administrationin the 9 cases, these regimens were established as protocols ofthe center.Conclusions: Dosage development and patient administrationhave a practical application and can help to decrease thepotential mistakes related to the complexity of the process
