ABSTRACT
The aim of this study was the evaluation of the measurement of sCD23 and IgE levels before and after immunotherapy. The research was conducted in a group of 23 children aged 6 to 18 years with pollinosis diagnosed on the basis of the patient's history, increased IgE level and positive skin tests with pollen allergens. The control group consisted of 10 healthy children in the same age with normal IgE level. The treated children were examined before and 6 weeks after immunotherapy. Before immunotherapy in both groups of children (with the high and medium IgE level) the sCD23 concentration was statistically higher (level of significance p < 0.001) compared to the sCD23 level in the healthy children. After immunotherapy we observed significant decrease of the sCD23 level. We did not found correlation between sCD23 and IgE in children with pollinosis before and after immunotherapy.
Subject(s)
Immunotherapy , Receptors, IgE/blood , Rhinitis, Allergic, Seasonal/therapy , Adolescent , Child , Child, Preschool , Humans , Rhinitis, Allergic, Seasonal/immunologySubject(s)
Allergens/immunology , Dermatitis, Atopic/immunology , Epitopes , Immunoglobulin E/blood , Adolescent , Child , Child, Preschool , Dermatitis, Atopic/diagnosis , Female , Humans , Male , Skin TestsABSTRACT
Preparations, in which composition disodium cromoglycate goes into, have been for many years the admitted way of bronchial asthma treatment. The introduction, to the therapy, of preparation that contains reproterol as well makes possible the early remission of disease symptoms. The aim of the study was the estimation of the effectiveness of DNCG-comp. preparation. Twenty one children, aged 7-17 years, with recognized bronchial asthma were examined. The atopic basis of the disease was found on the ground of results of skin prick tests, and elevated concentration of serum IgE and positive atopic family interview. We resigned the hitherto treatment for 3 days, carried out the spirometric measurements (PEF, FEV1, FEV1%VC, MEF25,50,75). DNCG-comp. was given 4-times per twenty-four hours in 2 inhalations at each time, for three weeks. Every day, the PEF value and the score of disease symptoms were established. After the study, side effects were not observed and final results of spirometric estimation evidence the possibility of wide application of DNCG-comp. preparation in the treatment of bronchial asthma in childhood.
Subject(s)
Asthma/drug therapy , Bronchodilator Agents/therapeutic use , Cromolyn Sodium/therapeutic use , Metaproterenol/analogs & derivatives , Theophylline/analogs & derivatives , Administration, Inhalation , Adolescent , Child , Drug Administration Schedule , Drug Combinations , Female , Humans , Male , Metaproterenol/therapeutic use , Skin Tests , Spirometry , Theophylline/therapeutic use , Treatment OutcomeSubject(s)
Antibody Specificity , Asthma/immunology , Immunoglobulin E/blood , Adolescent , Asthma/diagnosis , Child , Child, Preschool , Female , Humans , Infant , Male , Skin TestsABSTRACT
A case is presented of a rare form of pulmonary miliary tuberculosis in a 14-year-old boy beginning with dramatic symptoms with negative the test and negative result of bacterioscopy. The preliminary diagnosis was made on the basis of clinical observation and radiological examination. Confirmation was achieved after obtaining of a positive result of bacteriological examination.
