Unmasking the COVID-19 pandemic prevention gains: excess mortality reversal in 2022.

OBJECTIVES: The purpose of this study was to assess the long-term effectiveness of COVID-19 pandemic prevention measures in saving lives after European governments began to lift restrictions. STUDY DESIGN: Excess mortality interrupted time series. METHODS: Country-level weekly data on deaths were fitted to the Poisson mixed linear model to estimate excess deaths. Based on this estimate, the percentage of excess deaths above the baseline during the pandemic (week 11 in 2020 to week 15 in 2022) (when public health interventions were in place) and during the post-pandemic period (week 16 in 2022 to week 52 in 2022) were calculated. These results were fitted to the linear regression model to determine any potential relationship between mortality during these two periods. RESULTS: The model used in this study had high predictive value (adjusted R2 = 59.4%). Mortality during the endemic (post-pandemic) period alone increased by 7.2% (95% confidence interval [CI]: 5.7, 8.6) above baseline, while each percentage increase in mortality during the pandemic corresponded to a 0.357% reduction (95% CI: 0.243, 0.471) in mortality during the post-pandemic period. CONCLUSIONS: The most successful countries in terms of protective measures also experienced the highest mortality rates after restrictions were lifted. The model used in this study clearly shows a measure of bidirectional mortality displacement that is sufficiently clear to mask any impact of long COVID on overall mortality. Results from this study also seriously impact previous cost-benefit analyses of pandemic prevention measures, since, according to the current model, 12.2% (95% CI: 8.3, 16.1) of the gains achieved in pandemic containment were lost after restrictions were lifted.

Influence of the surface properties on bactericidal and fungicidal activity of magnetron sputtered Ti-Ag and Nb-Ag thin films.

In this study the comparative investigations of structural, surface and bactericidal properties of Ti-Ag and Nb-Ag thin films have been carried out. Ti-Ag and Nb-Ag coatings were deposited on silicon and fused silica substrates by magnetron co-sputtering method using innovative multi-target apparatus. The physicochemical properties of prepared thin films were examined with the aid of X-ray diffraction, grazing incidence X-ray diffraction, scanning electron microscopy, atomic force microscopy and X-ray photoelectron spectroscopy methods. Moreover, the wettability of the surface was determined. It was found that both, Ti-Ag and Nb-Ag thin films were nanocrystalline. In the case of Ag-Ti film presence of AgTi3 and Ag phases was identified, while in the structure of Nb-Ag only silver occurred in a crystal form. In both cases the average size of crystallites was ca. 11 nm. Moreover, according to scanning electron microscopy and atomic force microscopy investigations the surface of Nb-Ag thin films was covered with Ag-agglomerates, while Ti-Ag surface was smooth and devoid of silver particles. Studies of biological activity of deposited coatings in contact with Bacillus subtilis, Pseudomonas aeruginosa, Enterococcus hirae, Klebisiella pneumoniae, Escherichia coli, Staphylococcus aureus and Candida albicans were performed. It was found that prepared coatings were bactericidal and fungicidal even in a short term-contact, i.e. after 2 h.

Determination of structural, mechanical and corrosion properties of Nb2O5 and (NbyCu 1-y)Ox thin films deposited on Ti6Al4V alloy substrates for dental implant applications.

In this paper comparative studies on the structural, mechanical and corrosion properties of Nb2O5/Ti and (NbyCu1-y)Ox/Ti alloy systems have been investigated. Pure layers of niobia and niobia with a copper addition were deposited on a Ti6Al4V titanium alloy surface using the magnetron sputtering method. The physicochemical properties of the prepared thin films were examined with the aid of XRD, XPS SEM and AFM measurements. The mechanical properties (i.e., nanohardness, Young's modulus and abrasion resistance) were performed using nanoindentation and a steel wool test. The corrosion properties of the coatings were determined by analysis of the voltammetric curves. The deposited coatings were crack free, exhibited good adherence to the substrate, no discontinuity of the thin film was observed and the surface morphology was homogeneous. The hardness of pure niobium pentoxide was ca. 8.64GPa. The obtained results showed that the addition of copper into pure niobia resulted in the preparation of a layer with a lower hardness of ca. 7.79 GPa (for niobia with 17 at.% Cu) and 7.75 GPa (for niobia with 25 at.% Cu). The corrosion properties of the tested thin films deposited on the surface of titanium alloy depended on the composition of the thin layer. The addition of copper (i.e. a noble metal) to Nb2O5 film increased the corrosion resistance followed by a significant decrease in the value of corrosion currents and, in case of the highest Cu content, the shift of corrosion potential towards the noble direction. The best corrosion properties were obtained from a sample of Ti6Al4V coated with (Nb0.75Cu0.25)Ox thin film. It seems that the tested materials could be used in the future as protection coatings for Ti alloys in biomedical applications such as implants.

Gasochromic switching of Ta and Pd-doped nanocrystalline TiO2 thin films.

In this work TiO2:(Ta, Pd) thin films with gasochromic properties have been described. Thin films were prepared by reactive magnetron sputtering process using mosaic Ti-Ta-Pd target. The amounts of dopants were 2.54 at.% and 12.36 at.% of Ta and Pd, respectively. The results of optical measurements performed at presence of ethanol and additional heating of the sample up to 350 degrees C have shown an abrupt change of transmission level from 80% down to 10% in VIS and in IR range. The gasochromic change was very fast. Moreover, rapid cooling (down to room temperature) in an air ambient results in stable thin film coloration. The reverse effect (bleaching) was obtained after annealing at 500 degrees C in an ambient air.

Optical measurement of rates of dissipation of temperature variance due to oceanic turbulence.

Inhomogeneities in the refractive index induced by temperature fluctuations in turbulent flows have the effect of scattering light in near-forward angles. We have developed a method that extracts the rate of Temperature Variance Dissipation (TVD) and its spectrum from the properties of light scattering and have built an instrument - Optical Turbulence Sensor (OTS) - that implements the method. OTS uses a linear wavefront sensing Hartmann array and allows for nearly instantaneous measurements of temperature variance in turbulent flows. The instrument has been tested in an situ experiment carried out from a drifting vessel at a site off the coast of Newport, Oregon. Here we compare the temperature variance measured by OTS and its spectra with both theoretical predictions and with spectra obtained from a fast thermistor sensor.

Comparison of near-forward light scattering on oceanic turbulence and particles.

We examine and compare near-forward light scattering that is caused by turbulence and typical particulate assemblages in the ocean. The near-forward scattering by particles was calculated using Mie theory for homogeneous spheres and particle size distributions representative of natural assemblages in the ocean. Direct numerical simulations of a passive scalar with Prandtl number 7 mixed by homogeneous turbulence were used to represent temperature fluctuations and resulting inhomogeneities in the refractive index of water. Light scattering on the simulated turbulent flow was calculated using the geometrical-optics approximation. We found that the smallest temperature scales contribute the most to scattering, and that scattering on turbulence typically dominates over scattering on particles for small angles as large as 0.1 degrees . The scattering angle deviation that is due to turbulence for a light beam propagating over a 0.25-m path length in the oceanic water can be as large as 0.1 degrees . In addition, we carried out a preliminary laboratory experiment that illustrates the differences in the near-forward scattering on refractive-index inhomogeneities and particles.