Subject(s)
Contact Lenses, Hydrophilic , Contact Lenses , Corneal Diseases , Keratitis , Anesthesia, Local , Anesthetics, Local , HumansABSTRACT
No disponible
Subject(s)
Humans , Adult , Biological Treatment/methods , Etanercept/therapeutic use , Adalimumab/therapeutic use , Ustekinumab/therapeutic use , Treatment Outcome , Retrospective StudiesSubject(s)
Adalimumab/therapeutic use , Dermatologic Agents/therapeutic use , Etanercept/therapeutic use , Psoriasis/drug therapy , Psoriasis/pathology , Severity of Illness Index , Ustekinumab/therapeutic use , Adalimumab/adverse effects , Adult , Anti-Inflammatory Agents/adverse effects , Anti-Inflammatory Agents/therapeutic use , Body Weight , Dermatologic Agents/adverse effects , Female , Humans , Male , Middle Aged , Retrospective Studies , Time Factors , Treatment Outcome , Ustekinumab/adverse effectsABSTRACT
Antecedentes y objetivo: Los ensayos pivotales de omalizumab en urticaria crónica espontánea (UCE) tienen un periodo de tratamiento de entre 12 y 24 semanas. Sin embargo, muchos pacientes en práctica clínica requieren periodos de tratamiento más prolongados. Por ello el objetivo es presentar un algoritmo de manejo del fármaco. Materiales y métodos: El documento de consenso que detallamos nace de la puesta en común, aceptación, revisión y confrontación de la literatura reciente del grupo de trabajo de UCE "Xarxa d'Urticària Catalana i Balear" (XUrCB). Resultados: Se inicia el tratamiento a dosis autorizada y se ajusta la dosis en intervalos trimestrales en función del Urticaria Activity Score de los últimos 7 días (UAS7) y/o el Urticarial Control Test (UCT). Conclusiones: El algoritmo propuesto pretende servir de guía respecto a cómo ajustar dosis, cómo y cuándo parar el fármaco y el modo de reintroducirlo en casos de recaída
Background and objective: Pivotal trials with omalizumab for treatment of chronic spontaneous urticaria (CSU) are generally run over 12 to 24weeks. However, in clinical practice, many patients need longer treatment. In this article, we present an algorithm for treatment with omalizumab. Material and methods: The consensus document we present is the result of a series of meetings by the CSU working group of "Xarxa d'Urticària Catalana i Balear" (XUrCB) at which data from the recent literature were presented, discussed, compared, and agreed upon. Results: Treatment with omalizumab should be initiated at the authorized dose, and is adjusted at 3-monthly intervals according to the Urticaria Activity Score Over 7 days, the Urticaria Control Test, or both. Conclusions: The algorithm proposed is designed to provide guidance on how to adjust omalizumab doses, how and when to discontinue the drug, and how to reintroduce it in cases of relapse
Subject(s)
Humans , Urticaria/drug therapy , Omalizumab/administration & dosage , Algorithms , Consensus , Dosage/methods , Histamine H1 Antagonists/administration & dosage , Dose-Response Relationship, DrugABSTRACT
BACKGROUND AND OBJECTIVE: Pivotal trials with omalizumab for treatment of chronic spontaneous urticaria (CSU) are generally run over 12 to 24weeks. However, in clinical practice, many patients need longer treatment. In this article, we present an algorithm for treatment with omalizumab. MATERIAL AND METHODS: The consensus document we present is the result of a series of meetings by the CSU working group of "Xarxa d'Urticària Catalana i Balear" (XUrCB) at which data from the recent literature were presented, discussed, compared, and agreed upon. RESULTS: Treatment with omalizumab should be initiated at the authorized dose, and is adjusted at 3-monthly intervals according to the Urticaria Activity Score Over 7days, the Urticaria Control Test, or both. CONCLUSIONS: The algorithm proposed is designed to provide guidance on how to adjust omalizumab doses, how and when to discontinue the drug, and how to reintroduce it in cases of relapse.
Subject(s)
Algorithms , Anti-Allergic Agents/therapeutic use , Omalizumab/therapeutic use , Urticaria/drug therapy , Anti-Allergic Agents/administration & dosage , Chronic Disease , Humans , Omalizumab/administration & dosageABSTRACT
Objetivo: Analizar el efecto de la utilización/implementación de 3métodos para reducir peso en pacientes con sobrepeso u obesidad, durante un año de seguimiento. Material y métodos: El diseño corresponde a un ensayo clínico, aleatorizado y controlado, doble ciego, con 3brazos y 12 meses de seguimiento. Los pacientes se aleatorizaron en 3grupos de intervención: intervención motivacional de obesidad con enfermera entrenada previamente en intervención motivacional por psicólogos expertos (G1; n=60); intervención en consulta de menor intensidad, sin grupo motivacional, con apoyo de plataforma digital (G2; n=61) y un tercer grupo que recibía recomendación de perder peso y seguimiento en consulta de Atención Primaria (G3; n=59). Se midieron las variables antropométricas (peso, talla y perímetro de cintura abdominal) y se consideró como principal medida de la efectividad del tratamiento el porcentaje de pacientes que lograron al año reducir su peso ≥5%. Resultados: Todos los grupos disminuyeron significativamente el peso al final del estudio. Fue más intensa la disminución en el G1 (−5,6kg), seguido del G2 (−4,3kg) y del G3 (−1,7kg); media en su conjunto: −3,9kg. Los indicadores de relevancia clínica fueron en el G1/G3: riesgo relativo (RR): 4,99 (IC 95%: 2,71 a 9,18); reducción relativa del riesgo (RRR): 399,1% (de 171,3 a 818,0); reducción absoluta del riesgo (RAR): 65,3% (de 51,5 a 79,1) y NNT: 2 (de 2 a 2). En los grupos G2/G3: RR: 3,01 (de 1,57 a 5,76); RRR: 200,5% (de 57,0 a 475,5); RAR: 32,8% (de 16,9 a 48,7) y NNT: 4 (de 3 a 6). En los grupos G1/G2: RR: 1,66 (de 1,25 a 2,20); RRR: 66,1% (de 25,3 a 120,1); RAR: 32,5% (de 16,6 a 48,4) y NNT: 4 (de 3 a 7). Conclusiones: Los 3grupos consiguieron reducir el peso, si bien el grupo con intervención motivacional alcanzó la mayor disminución y los indicadores de relevancia clínica más favorables (AU)
Objective: To analyse the effect of the use/implementation of 3methods to reduce weight in overweight or obese patients during one year of follow up. Material and methods: The design corresponds to a double-blind, randomised, controlled clinical trial with 3arms, and 12 months of follow-up. Patients were randomised into 3intervention groups: obesity motivational intervention, with a nurse previously trained in motivational intervention by expert psychologists (G1; n=60); lower intensity consultation, non-motivational group, with digital platform support (G2; N=61), and a third group that received recommendations for weight loss and follow-up in Primary Care Clinic (G3; n=59). Anthropometric variables (weight, height, and abdominal-waist circumference) were measured, and the percentage of patients who managed to reduce their weight ≥5% was considered as the main measurement of treatment effectiveness. Results: All groups significantly decreased body weight at the end of the study, with a reduction in G1 (−5.6kg) followed by G2 (−4.3kg), and G3 (−1.7kg), with an overall mean: −3.9kg. The indicators of clinical relevance were in G1/G3: relative risk (RR): 4.99 (95% CI: from 2.71 to 9.18); relative risk reduction (RRR): 399.1% (171.3 to 818.0); Absolute risk reduction (RAR): 65.3% (from 51.5 to 79.1) and NNT: 2 (from 2 to 2). In the G2/G3 groups: RR: 3.01 (from 1.57 to 5.76); RRR: 200.5% (from 57.0 to 475.5); RAR: 32.8% (from 16.9 to 48.7) and NNT: 4 (from 3 to 6). In the G1/G2 groups: RR: 1.66 (from 1.25 to 2.20); RRR: 66.1% (from 25.3 to 120.1); RAR: 32.5% (from 16.6 to 48.4) and NNT: 4 (from 3 to 7). Conclusions: All 3groups were able to reduce weight. Although the group with motivational intervention achieved the greatest decrease, as well as the most favourable clinical relevance indicators (AU)
Subject(s)
Humans , Weight Loss/physiology , Overweight/diagnosis , Overweight/therapy , Follow-Up Studies , Obesity/complications , Primary Health Care , Anthropometry/methods , Telemedicine/methods , Body Mass Index , Waist-Hip Ratio/methodsSubject(s)
Anti-Allergic Agents/administration & dosage , Chronic Disease/drug therapy , Omalizumab/administration & dosage , Urticaria/drug therapy , Adult , Age Factors , Dose-Response Relationship, Drug , Drug Resistance , Female , Humans , Middle Aged , Retrospective Studies , Treatment Outcome , Urticaria/pathologyABSTRACT
OBJECTIVE: To analyse the effect of the use/implementation of 3methods to reduce weight in overweight or obese patients during one year of follow up. MATERIAL AND METHODS: The design corresponds to a double-blind, randomised, controlled clinical trial with 3arms, and 12 months of follow-up. Patients were randomised into 3intervention groups: obesity motivational intervention, with a nurse previously trained in motivational intervention by expert psychologists (G1; n=60); lower intensity consultation, non-motivational group, with digital platform support (G2; N=61), and a third group that received recommendations for weight loss and follow-up in Primary Care Clinic (G3; n=59). Anthropometric variables (weight, height, and abdominal-waist circumference) were measured, and the percentage of patients who managed to reduce their weight ≥5% was considered as the main measurement of treatment effectiveness. RESULTS: All groups significantly decreased body weight at the end of the study, with a reduction in G1 (-5.6kg) followed by G2 (-4.3kg), and G3 (-1.7kg), with an overall mean: -3.9kg. The indicators of clinical relevance were in G1/G3: relative risk (RR): 4.99 (95% CI: from 2.71 to 9.18); relative risk reduction (RRR): 399.1% (171.3 to 818.0); Absolute risk reduction (RAR): 65.3% (from 51.5 to 79.1) and NNT: 2 (from 2 to 2). In the G2/G3 groups: RR: 3.01 (from 1.57 to 5.76); RRR: 200.5% (from 57.0 to 475.5); RAR: 32.8% (from 16.9 to 48.7) and NNT: 4 (from 3 to 6). In the G1/G2 groups: RR: 1.66 (from 1.25 to 2.20); RRR: 66.1% (from 25.3 to 120.1); RAR: 32.5% (from 16.6 to 48.4) and NNT: 4 (from 3 to 7). CONCLUSIONS: All 3groups were able to reduce weight. Although the group with motivational intervention achieved the greatest decrease, as well as the most favourable clinical relevance indicators.
Subject(s)
Motivational Interviewing , Overweight/therapy , Patient Education as Topic , Therapy, Computer-Assisted , Weight Loss , Adult , Aged , Anthropometry , Double-Blind Method , Female , Follow-Up Studies , Humans , Male , Middle Aged , Obesity/nursing , Obesity/therapy , Overweight/nursing , Programmed Instructions as Topic , Software , Telemedicine , Treatment OutcomeABSTRACT
No disponible
Subject(s)
Adult , Humans , Male , Corneal Perforation/complications , Corneal Perforation/diagnosis , Corneal Perforation/therapy , Corneal Transplantation/trends , Corneal Transplantation , Ophthalmology/trends , Eye/anatomy & histology , Eye/pathologyABSTRACT
No disponible
Subject(s)
Adult , Female , Humans , Male , Retina/abnormalities , Retina/pathology , Pharmaceutical Preparations/administration & dosage , Pharmaceutical Preparations/metabolism , Macular Degeneration/genetics , HIV Infections/virology , Retina/injuries , Retina/metabolism , Pharmaceutical Preparations/classification , Pharmaceutical Preparations/standards , Macular Degeneration/metabolism , HIV Infections/complicationsABSTRACT
No disponible
Subject(s)
Humans , Erythema/etiology , Facial Dermatoses/etiology , Flushing/diagnosis , Alcohol Drinking/physiopathology , Biomarkers/analysis , Brimonidine Tartrate/therapeutic use , Diagnosis, Differential , Emotions , Endocrine System DiseasesSubject(s)
Corneal Transplantation/methods , Corneal Ulcer/surgery , Adult , Biological Dressings , Bucrylate/therapeutic use , Combined Modality Therapy , Contact Lenses , Cornea , Corneal Pachymetry , Corneal Ulcer/diagnostic imaging , Corneal Ulcer/etiology , Corneal Ulcer/therapy , Desiccation , Dexamethasone/adverse effects , Humans , Keratoplasty, Penetrating/adverse effects , Male , Organ Preservation/methods , Self Medication , Silica Gel , Tissue Adhesives/therapeutic use , Tomography, Optical CoherenceABSTRACT
No disponible
Subject(s)
Humans , Hutchinson's Melanotic Freckle/diagnosis , Hutchinson's Melanotic Freckle/therapy , Skin Neoplasms/diagnosis , Skin Neoplasms/therapySubject(s)
Darunavir/adverse effects , HIV Infections/drug therapy , HIV Protease Inhibitors/adverse effects , Retinal Dystrophies/chemically induced , Anti-HIV Agents/therapeutic use , Antiretroviral Therapy, Highly Active , Darunavir/therapeutic use , Female , HIV Infections/congenital , HIV Protease Inhibitors/therapeutic use , Humans , Levofloxacin/therapeutic use , Meropenem , Ophthalmoscopy , Pneumonia, Pneumococcal/complications , Pneumonia, Pneumococcal/drug therapy , Polypharmacy , Retinal Dystrophies/complications , Thienamycins/therapeutic use , Young AdultSubject(s)
Erythema/etiology , Facial Dermatoses/etiology , Flushing/diagnosis , Alcohol Drinking/physiopathology , Biomarkers/blood , Biomarkers/urine , Brimonidine Tartrate/therapeutic use , Diagnosis, Differential , Emotions , Endocrine System Diseases/complications , Endocrine System Diseases/physiopathology , Flushing/etiology , Flushing/metabolism , Flushing/physiopathology , Humans , Neoplasms/complications , Neoplasms/physiopathology , Symptom AssessmentABSTRACT
Idiopathic dilated cardiomyopathy (IDC) is a structural heart disease with strong genetic background. The different single nucleotide polymorphisms (SNPs) that constitute mitochondrial haplogroups could play an important role in IDC progression. The aim of this study was to test frequencies of mitochondrial haplogroups in healthy controls (n=422) and IDC patients (n=304) of a Caucasian Spanish population. To achieve this, ten major European haplogroups were identified. Frequencies and Odds Ratios for the association between IDC and haplogroups were calculated in both groups. We found that compared to healthy controls, the prevalence of haplogroup H was significantly higher in IDC patients (40.0% vs 50.7%, p-value=0.040).
Subject(s)
Cardiomyopathy, Dilated/epidemiology , Cardiomyopathy, Dilated/genetics , DNA, Mitochondrial/genetics , Haplotypes , Adult , Aged , Female , Gene Frequency , Humans , Male , Middle Aged , Risk Factors , Spain/epidemiologyABSTRACT
Stem cell therapy constitutes an exciting, powerful therapy to repair the heart. Nevertheless, there are numerous doubts about the best route of stem cell administration to achieve implantation into the injured myocardium. Development of a preclinical, large animal model may be useful to obtain a better approach to clinical situations. The aim of this work was to study the effectiveness of various routes of heterologous bone marrow mesenchymal stem cell (MSCs) administration in a porcine model of myocardial infarction. MSC treated with 5-azacytidine were stained with a fluorescent compound (DiO) before their administration to previously infarcted pigs via 3 routes: intracoronary (IC), intramyocardial (IM), or endocardial (EC; n = 5 each group). Healthy, noninfarcted animals were used as a control group. At 30 days after delivery, hearts were divided into 12 parts: infarcted zone (1-6), right-left atria, interatrial and interventricular septa, and right-left ventricles. In each zone we looked for and quantified, injected fluorescence-stained cells. In the animals in which presence of DiO-stained cells was detected, cells were located preferentially in the infarcted zone and not in the atria, ventricles, or septa. Comparing various administration routes, the mean number of engrafted cells within the infarct zone was significantly greater after IC infusion than either IM or EC injection. Fluorescent cells were not observed in healthy zones of the myocardium or in healthy animals.
Subject(s)
Azacitidine/therapeutic use , Mesenchymal Stem Cell Transplantation/methods , Myocardial Infarction/surgery , Animals , Azacitidine/administration & dosage , Azacitidine/pharmacology , Disease Models, Animal , Myocardial Infarction/drug therapy , SwineABSTRACT
Myocardial infarction is one of the main causes of mortality in developed countries. Injection of bone marrow mesenchymal stem cells (BMMSC) with the ability to regenerate lost cardiomyocytes is a promising therapy for heart failure. To evaluate this strategy, an in vivo porcine model of infarction was used. Gene expression profiles of 3 groups of pigs (n = 5 each) were analyzed and compared by real-time reverse transcription-polymerase chain reaction (RT-PCR). One of the groups underwent anterior descending coronary occlusion followed by BMMSC injection; a placebo group was injected with culture medium without cells after infarction; and a third group was formed by healthy pigs. Four weeks later, cells or medium was administered by intracoronary injection and, a month later, animals were sacrificed and samples collected. Genes related to cardiomyogenesis (Mef2C, Gata4, Nkx2.5), mobilization and homing of resident or circulating stem cells (Sdf1, Cxcr4, c-Kit), contractibility (Serca2a), and fibrosis (CollA1) were analyzed. Gene expression profiles changed in various heart areas in the 3 groups. Expression of genes related to cardiomyogenesis decreased in infarcted zones compared with homologous regions of healthy hearts. Sdf1 expression increased in the apex of infarcted hearts. Serca2a expression was reduced in the ventricles and atria of infarcted hearts. Also, increases in Cxcr4 and CollA1 expression were observed in infarcted hearts of cell-treated pigs compared with the placebo group. In conclusion, infarction induced changes in genes involved in various biological processes. Intracoronary injection of heterologous BMMSC resulted in localized changes in the expression of Cxcr4 and Col1A1.
Subject(s)
Collagen Type I/genetics , Gene Expression Profiling , Mesenchymal Stem Cell Transplantation/methods , Myocardial Infarction/genetics , Myocardial Infarction/surgery , Animals , Disease Models, Animal , Mesenchymal Stem Cell Transplantation/veterinary , Myocardial Infarction/veterinary , SwineABSTRACT
An in vivo porcine model of myocardial infarction was developed with the aim of comparing the effectiveness for cardiac repair of intracoronary, transthoracic, or transendocardial delivery strategies for bone marrow mesenchymal stem cells (BMMSC) using an analysis of expression levels of transcripts related to various cellular processes at 8 heart regions using quantitative reverse transcriptase polymerase chain reaction. We observed significant rises in cardiomyogenic markers Mef2C, Gata4 and Nkx2.5, and contractibility marker Serca2A at infarcted regions for cell-treated pigs. We also observed differences in Sdf1 expression related to the organ stress response between delivery strategies. Unexpectedly, increased expression of Col1A1 was detected in 2 cell-treated groups at various heart regions. Our results suggest improvements in both contractility and cardiomyogenic capability of damaged tissue after BMMSC injection, but also warned us about the relevance of the chosen delivery strategy and potential undesired effects like increasing fibrosis after treatment.