ABSTRACT
We have synthesized and characterized a water-soluble gold(III) corrole (1-Au) that is highly toxic to cisplatin-resistant cancer cells. Relative to its 1-Ga analogue, axial ligands bind only weakly to 1-Au, which likely accounts for its lower affinity for human serum albumin (HSA). We suggest that the cytotoxicity of 1-Au may be related to this lower HSA affinity.
Subject(s)
Antineoplastic Agents , Gold , Organogold Compounds , Porphyrins , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Cell Line, Tumor , Cell Survival/drug effects , Cytostatic Agents/chemistry , Cytostatic Agents/pharmacology , Cytotoxins/chemistry , Cytotoxins/pharmacology , Gallium/chemistry , Gallium/pharmacology , Gold/chemistry , Gold/pharmacology , Humans , Organogold Compounds/chemistry , Organogold Compounds/pharmacology , Porphyrins/chemistry , Porphyrins/pharmacology , Serum Albumin/chemistry , Serum Albumin/metabolismABSTRACT
The synthesis of two pyridylamidinate bis(N,N'-bis(trimethylsilyl)-2-pyridylamidinate)An(µ-Cl)2Li(TMEDA) (An = U (1), Th (2)) complexes is presented. For complex 1 the solid state X-ray structures were studied and compared to that of complex 2. The organoactinide complexes were studied as pre-catalysts in the polymerization of ethylene when activated by methylalumoxane (MAO). The catalytic activity was improved using a mixture of trityl tetrakispentafluorophenylborate (TTPB) and a small amount of methylalumoxane (MAO) as cocatalysts, and was amazingly improved, providing the greatest activity, using only triisobutyl aluminum (TIBA). We present a combination of ESR, C60 radical trapping, and MALDI-TOF studies describing the formation of the single-site active species, capturing some unique features of the complexes and shedding light on the polymerization mechanism.
