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2.
Front Physiol ; 15: 1347093, 2024.
Article in English | MEDLINE | ID: mdl-38516209

ABSTRACT

Introduction: There are several tests that provide information about physical fitness and functionality in older adults. The aims of this study were: (i) to analyze the differences between sex and age in functional, strength and cardiorespiratory tests; and (ii) to study the correlations between functional, strength and cardiorespiratory tests according to sex and age. Methods: A total of 171 older adults (72.09 ± 13.27 kg; 1.59 ± 0.09 m; 72.72 ± 6.05 years) were divided according to sex (men: n = 63; women: n = 108) and age (≥60 <70: n = 65; ≥70 <80: n = 89; ≥80: n = 18). Anthropometry, body composition, upper limb strength (hand grip; HG), lower limb strength (countermovement jump; CMJ), cardiorespiratory capacity (6 min walking test; 6MWT), timed up and go test (TUG) and Short Physical Performance Battery (SPPB) were assessed. Results: Men showed higher values in CMJ height, HG and expired volume (VE) (p < 0.05). There were no significant differences between sexes in TUG and SPPB. Regarding age, there were significant differences in CMJ, VE and peak oxygen uptake (VO2peak), TUG, gait speed, chair and stand test and SPPB total (p < 0.05). The test times were higher in older people. Regarding correlations, the TUG showed significant correlations in all strength and cardiorespiratory tests, regardless of sex and age. The CMJ correlated more significantly with functional tests compared to HG. Discussion: There were sex and age differences in functional, strength, and cardiorespiratory tests. The execution of quick and low-cost tests such as the CMJ and TUG could provide information on overall physical fitness in older adults.

3.
PLoS One ; 19(3): e0298859, 2024.
Article in English | MEDLINE | ID: mdl-38512981

ABSTRACT

The aim of this study was to investigate the reliability and validity of an affordable wireless force sensor in measuring mean and peak forces during resistance training.A Suiff Pro wireless force sensor (Suiff, Spain) and a MuscleLab force platform (Ergotest, Norway) were used concurrently to assess tensile load and the ground reaction force resulting from an upright row exercise. Thirteen participants (28.2 ± 5.7 years, 76.2 ± 9.6 kg, 178.2 ± 9.2 cm) performed the exercise under three velocity conditions and isometrically. Each condition involved three sets of exercise. Mean (Fmean) and peak (Fpeak) force values from both sensors were collected and compared.Suiff Pro exhibited excellent reliability for Fmean and Fpeak (ICCs = 0.99). When compared to the criterion measures, Suiff Pro showed trivial standardized bias for Fmean (Mean = 0.00 [CI 95% = 0.00 to 0.01]) and Fpeak (-0.02 [-0.04 to 0.00]). The standardized typical error was also trivial for Fmean (0.03 [0.02 to 0.03]) and Fpeak (0.07 [0.05 to 0.09]). Correlations with the MuscleLab force platform were nearly perfect: Fmean (0.97 [0.94 to 0.98]; p<0.001); Fpeak (0.96 [0.92 to 0.97]; p<0.001).The findings demonstrate that the Suiff Pro sensor is reliable and valid device for measuring force during isometric and dynamic resistance training exercises. Therefore, practitioners can confidently use this device to monitor kinematic variables of resistance training exercises and to obtain real-time augmented feedback during a training session.


Subject(s)
Mobile Applications , Resistance Training , Humans , Resistance Training/methods , Reproducibility of Results , Exercise , Biomechanical Phenomena , Muscle Strength
4.
Adv Mater ; 36(24): e2312008, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38501999

ABSTRACT

Antiferromagnetic (AFM) materials are a pathway to spintronic memory and computing devices with unprecedented speed, energy efficiency, and bit density. Realizing this potential requires AFM devices with simultaneous electrical writing and reading of information, which are also compatible with established silicon-based manufacturing. Recent experiments have shown tunneling magnetoresistance (TMR) readout in epitaxial AFM tunnel junctions. However, these TMR structures are not grown using a silicon-compatible deposition process, and controlling their AFM order required external magnetic fields. Here are shown three-terminal AFM tunnel junctions based on the noncollinear antiferromagnet PtMn3, sputter-deposited on silicon. The devices simultaneously exhibit electrical switching using electric currents, and electrical readout by a large room-temperature TMR effect. First-principles calculations explain the TMR in terms of the momentum-resolved spin-dependent tunneling conduction in tunnel junctions with noncollinear AFM electrodes.

5.
Nanotechnology ; 34(49)2023 Sep 25.
Article in English | MEDLINE | ID: mdl-37669644

ABSTRACT

Probabilistic (p-) computing is a physics-based approach to addressing computational problems which are difficult to solve by conventional von Neumann computers. A key requirement for p-computing is the realization of fast, compact, and energy-efficient probabilistic bits. Stochastic magnetic tunnel junctions (MTJs) with low energy barriers, where the relative dwell time in each state is controlled by current, have been proposed as a candidate to implement p-bits. This approach presents challenges due to the need for precise control of a small energy barrier across large numbers of MTJs, and due to the need for an analog control signal. Here we demonstrate an alternative p-bit design based on perpendicular MTJs that uses the voltage-controlled magnetic anisotropy (VCMA) effect to create the random state of a p-bit on demand. The MTJs are stable (i.e. have large energy barriers) in the absence of voltage, and VCMA-induced dynamics are used to generate random numbers in less than 10 ns/bit. We then show a compact method of implementing p-bits by using VC-MTJs without a bias current. As a demonstration of the feasibility of the proposed p-bits and high quality of the generated random numbers, we solve up to 40 bit integer factorization problems using experimental bit-streams generated by VC-MTJs. Our proposal can impact the development of p-computers, both by supporting a fully spintronic implementation of a p-bit, and alternatively, by enabling true random number generation at low cost for ultralow-power and compact p-computers implemented in complementary metal-oxide semiconductor chips.

7.
Dolor ; 33(76): 24-28, ago. 2023.
Article in Spanish | LILACS | ID: biblio-1510386

ABSTRACT

Una deficiente calidad del manejo del dolor post operatorio agudo genera aumento en la morbilidad perioperatoria, disminuye la calidad de vida del paciente, aumenta los reingresos hospitalarios y, finalmente, los costes en salud. La analgesia preventiva y multimodal son dos estrategias que han sido implementadas para tratar de optimizar el manejo del dolor. Si bien en la primera, la evidencia es favorable a su empleo, aún no existe un total consenso en esto. A su vez, la analgesia multimodal, al emplear diferentes fármacos y/o técnicas, ha logrado evidenciar de mejor manera su utilidad y los beneficios al implementarla como terapia. En este artículo, revisamos la evidencia que certifica y avala el uso de éstas. Finalmente, a nuestro parecer, lo más importante en el quehacer del clínico, es lograr individualizar la estrategia que usaremos en el manejo del dolor postoperatorio, adaptándonos a las necesidades y el contexto propio de cada uno de nuestros pacientes.


A poor quality of acute postoperative pain management generates an increase in perioperative morbidity, decreases the quality of life of the patient, increases hospital readmissions and finally, increases health costs. Preventive and multimodal analgesia are two strategies that are implemented to try to optimize pain management. Although in the first, the evidence is favorable to its use, there is still no total consensus. At the same time, multimodal analgesia, by using different drugs and/or techniques, has demonstrated, in a better way, its usefulness and benefits when implemented as a therapy. In this article, we review the evidence that certifies and supports the use of these techniques. Finally, in our opinion, the most important thing in the clinician's task is to be able to individualize the strategy that we will use in postoperative pain management, adapting to the needs and context of each one of our patients.


Subject(s)
Humans , Pain, Postoperative/drug therapy , Analgesia/methods , Quality of Life
8.
Biol Sport ; 40(3): 805-811, 2023 Jul.
Article in English | MEDLINE | ID: mdl-37398963

ABSTRACT

The purpose of this study was to investigate the validity of a low-cost friction encoder against a criterion measure (strain gauge combined with a linear encoder) for assessing velocity, force and power in flywheel exercise devices. Ten young and physically active volunteers performed two sets of 14 maximal squats on a flywheel inertial device (YoYo Technology, Stockholm, Sweden) with five minutes rest between each set. Two different resistances were used (0.075 kg · m2 for the first set; 0.025 kg · m2 for the second). Mean velocity (Vrep), force (Frep) and power (Prep) for each repetition were assessed simultaneously via a friction encoder (Chronojump, Barcelona, Spain), and with a strain gauge combined with a linear encoder (MuscleLab 6000, Ergotest Technology, Porsgrunn, Norway). Results are displayed as (Mean [CI 90%]). Compared to criterion measures, mean bias for the practical measures of Vrep, Frep and Prep were moderate (-0.95 [-0.99 to -0.92]), small (0.53 [0.50 to 0.56]) and moderate (-0.68 [-0.71 to -0.65]) respectively. The typical error of estimate (TEE) was small for all three parameters; Vrep (0.23 [0.20 to 0.25]), Frep (0.20 [0.18 to 0.22]) and Prep (0.18 [0.16 to 0.20]). Correlations with MuscleLab were nearly perfect for all measures in all load configurations. Based on these findings, the friction encoder provides valid measures of velocity, force and power in flywheel exercise devices. However, as error did exist between measures, the same testing protocol should be used when assessing changes in these parameters over time, or when aiming to perform inter-individual comparisons.

9.
Neurocirugía (Soc. Luso-Esp. Neurocir.) ; 33(6): 284-292, nov.-dic. 2022. ilus, tab
Article in Spanish | IBECS | ID: ibc-212985

ABSTRACT

Introducción La mielopatía cervical degenerativa representa una entidad patológica producida por la estenosis del canal medular cervical, resultando en una compresión crónica de la médula espinal, variable y progresiva. El abordaje quirúrgico de la columna cervical puede realizarse por vía anterior y/o vía posterior. Respecto al abordaje posterior, existen 2 técnicas fundamentales: laminoplastia y laminectomía con fijación posterior (LFP). En la literatura actual existe controversia acerca de cuál de las 2 técnicas permite obtener mejores resultados postoperatorios. El objetivo es el estudio de las diferencias entre laminoplastia y LFP desde el punto de vista clínico y radiológico. Materiales y métodosSe realiza un estudio de una cohorte histórica de 39 pacientes (12 LFP y 27 laminoplastia) intervenidos en un período de 10 años en el Hospital Universitario La Paz con un seguimiento de 12 meses tras la cirugía. Se analizan y comparan los resultados clínicos mediante la escala de Nurick y la Escala Japanese Orthopaedic Association modificada (mJOA) y los resultados radiológicos mediante el ángulo de Cobb, eje sagital vertical, T1 Slope y el alineamiento (medido mediante Cobb-T1 Sloppe). Resultados Se observan diferencias significativas en la mejoría postoperatoria de la escala Nurick (p=0,008) y mJOA (p=0,018) en el grupo de laminoplastia. En LFP se objetiva una tendencia a una mejoría mayor, pero no se alcanza la significación estadística debido al bajo tamaño muestral de este grupo. No se objetivan diferencias estadísticamente significativas en cuanto a la variables radiológicas. Respecto al total de complicaciones, se observó un número mayor en el grupo de laminoplastia (7 casos) frente a LFP (un caso), pero no se vieron diferencias estadísticamente significativas... (AU)


Introduction Cervical degenerative myelopathy is a variable and progressive degenerative disease caused by chronic compression of the spinal cord. Surgical approaches for the cervical spine can be performed anteriorly and/or posteriorly. Regarding the posterior approach, there are 2 fundamental techniques: laminoplasty and laminectomy with posterior fixation (LPF). There is still controversy concerning the technique in terms of outcome and complications. The aim of the present work is to analyze from the clinical and radiological point of view these 2 techniques: laminoplasty and LPF. Materials and methods A historical cohort of 39 patients was reviewed (12 LFP and 27 laminoplasty) including patients operated in a 10 years period at the Hospital Universitario La Paz with a follow-up of 12 months after surgery was carried out. The clinical results were analyzed and compared using the Nurick scale and the modified Japanese Orthopaedic Association Scale (mJOA) and the radiological results using the Cobb angle, Sagittal Vertical Axis, T1 Slope and alignment (measured by Cobb-T1 Sloppe). Results Significant differences were observed in the postoperative improvement of the Nurick scale (P=.008) and mJOA (P=.018) in the laminoplasty group. In LFP there is a tendency to a greater improvement, but statistical significance is not reached due to the low sample size of this group. No statistically significant differences were observed in the radiological variables. Regarding the total number of complications, a higher number was observed in the laminoplasty group (7 cases) versus LFP (one case), but no statistically significant differences were observed. (AU)


Subject(s)
Humans , Male , Female , Spinal Cord Diseases/surgery , Spinal Cord Diseases/diagnostic imaging , Laminectomy/methods , Laminoplasty/methods , Cervical Vertebrae/diagnostic imaging , Cervical Vertebrae/surgery , Treatment Outcome , Retrospective Studies , Cohort Studies
10.
Polymers (Basel) ; 14(18)2022 Sep 15.
Article in English | MEDLINE | ID: mdl-36146008

ABSTRACT

Molecular dynamics simulations of ultrathin free-standing layers made of melted (373.15-673.15 K) polyethylene chains, which exhibit a lower melting temperature (compared to the bulk value), were carried out to investigate the dominant pressure forces that shape the conformation of chains at the interfacial and bulk liquid regions. We investigated layer thicknesses, tL, from the critical limit of mechanical stability up to lengths of tens of nm and found a normal distribution of bonds dominated by slightly stretched chains across the entire layer, even at large temperatures. In the bulk region, the contribution of bond vibrations to pressure was one order of magnitude larger than the contributions from interchain interactions, which changed from cohesive to noncohesive at larger temperatures just at a transition temperature that was found to be close to the experimentally derived onset temperature for thermal stability. The interchain interactions produced noncohesive interfacial regions at all temperatures in both directions (normal and lateral to the surface layer). Predictions for the value of the surface tension, γ, were consistent with experimental results and were independent of tL. However, the real interfacial thickness-measured from the outermost part of the interface up to the point where γ reached its maximum value-was found to be dependent on tL, located at a distance of 62 Šfrom the Gibbs dividing surface in the largest layer studied (1568 chains or 313,600 bins); this was ~4 times the length of the interfacial thickness measured in the density profiles.

11.
Phys Rev E ; 105(6-1): 064132, 2022 Jun.
Article in English | MEDLINE | ID: mdl-35854559

ABSTRACT

We outline an approach to calculating the quantum mechanical propagator in the presence of geometrically nontrivial Dirichlet boundary conditions. The method is based on a generalization of an integral transform of the propagator studied in previous work (the so-called "hit function") and a convergent sequence of Padé approximants that exposes the limit of perfectly reflecting boundaries. In this paper the generalized hit function is defined as a many-point propagator, and we describe its relation to the sum over trajectories in the Feynman path integral. We then show how it can be used to calculate the Feynman propagator. We calculate analytically all such hit functions in D=1 and D=3 dimensions, giving recursion relations between them in the same or different dimensions and apply the results to the simple cases of propagation in the presence of perfectly conducting planar and spherical plates. We use these results to conjecture a general analytical formula for the propagator when Dirichlet boundary conditions are present in a given geometry, also explaining how it can be extended for application for more general, nonlocalized potentials. Our work has resonance with previous results obtained by Grosche in the study of path integrals in the presence of delta potentials. We indicate the eventual application in a relativistic context to determining Casimir energies using this technique.

12.
J Neurosurg Case Lessons ; 4(2): CASE21667, 2022 Jul 11.
Article in English | MEDLINE | ID: mdl-35855010

ABSTRACT

BACKGROUND: Strongyloidiasis is an underdiagnosed and preventable life-threatening disease caused by infection with the helminth Strongyloides stercoralis. Chronic asymptomatic infection can be sustained for decades, and immunosuppression can lead to disseminated infection, with a mortality rate of 70%-100%. In the neurosurgical population, corticosteroids are the most consistent cause of hyperinfection. OBSERVATIONS: The authors present the case of a 33-year-old woman of Paraguayan origin who was diagnosed with sphenoid planum meningioma and treated with a high dose of corticosteroids on the basis of the diagnosis. She underwent surgery, and pathological anatomy reflected grade I meningioma. After the surgery, she started with a history of dyspnea, productive cough, fever, and urticarial rash. Later, she presented with intestinal pseudo-obstruction and bacterial meningitis with hydrocephalus. Serology was positive for Strongyloides (enzyme-linked immunosorbent assay), and she was diagnosed with hyperinfection syndrome. Ivermectin 200 µg/kg daily was established. LESSONS: It may be of interest to rule out a chronic Strongyloides infection in patients from risk areas (immigrants or those returning from recent trips) before starting treatment with corticosteroids.

13.
Neurocirugia (Astur : Engl Ed) ; 33(6): 284-292, 2022.
Article in English | MEDLINE | ID: mdl-34799283

ABSTRACT

INTRODUCTION: Cervical degenerative myelopathy is a variable and progressive degenerative disease caused by chronic compression of the spinal cord. Surgical approaches for the cervical spine can be performed anteriorly and/or posteriorly. Regarding the posterior approach, there are 2 fundamental techniques: laminoplasty and laminectomy with posterior fixation (LPF). There is still controversy concerning the technique in terms of outcome and complications. The aim of the present work is to analyze from the clinical and radiological point of view these 2 techniques: laminoplasty and LPF. MATERIALS AND METHODS: A historical cohort of 39 patients was reviewed (12 LFP and 27 laminoplasty) including patients operated in a 10 years period at the Hospital Universitario La Paz with a follow-up of 12 months after surgery was carried out. The clinical results were analyzed and compared using the Nurick scale and the modified Japanese Orthopaedic Association Scale (mJOA) and the radiological results using the Cobb angle, Sagittal Vertical Axis, T1 Slope and alignment (measured by Cobb-T1 Sloppe). RESULTS: Significant differences were observed in the postoperative improvement of the Nurick scale (p = 0.008) and mJOA (p = 0.018) in the laminoplasty group. In LFP there is a tendency to a greater improvement, but statistical significance is not reached due to the low sample size of this group. No statistically significant differences were observed in the radiological variables. Regarding the total number of complications, a higher number was observed in the laminoplasty group (7 cases) versus LFP (one case), but no statistically significant differences were observed. CONCLUSIONS: Laminoplasty and LFP are both safe and effective procedures in the treatment of cervical degenerative myelopathy. The findings of our study demonstrate statistically significant clinical improvement based on the Nurick and mJOA scales with laminoplasty. No significant differences in terms of complications or radiological variables were observed between the 2 techniques.


Subject(s)
Laminoplasty , Spinal Cord Diseases , Humans , Laminoplasty/adverse effects , Laminoplasty/methods , Laminectomy/methods , Treatment Outcome , Spinal Cord Diseases/diagnostic imaging , Spinal Cord Diseases/surgery , Cervical Vertebrae/diagnostic imaging , Cervical Vertebrae/surgery
14.
Br J Neurosurg ; : 1-7, 2021 Oct 07.
Article in English | MEDLINE | ID: mdl-34615413

ABSTRACT

BACKGROUND: The H3K27M-mutant spinal cord gliomas are very aggressive with a dismal prognosis, very few cases have been reported in the thoracic spinal cord and conus medullaris, and it is extremely rare with morphological features of pilocytic astrocytoma. CASE PRESENTATION: A 20-year-old man presented with thoracolumbar pain, progressive paraparesis, and urinary incontinence. Magnetic resonance imaging revealed an intramedullary solid-cystic lesion from D9 to conus medullaris. Subtotal resection was performed, restricted by the indistinct margins and the decline of the motor evoked potential during the surgery. Pathologic findings revealed a pilocytic astrocytoma with anaplastic features. However, a further assessment determined a diffuse midline glioma H3K27M-mutant, and adjuvant chemoradiotherapy was administered. After seven months of progression-free survival, the paraparesis worsened; at twelve months of follow-up, the patient developed paraplegia, and at 24 months the patient remains alive without any neurologic functions distal to the tumor and he is still under adjuvant treatment. CONCLUSIONS: The H3K27M-mutant spinal cord glioma is a very infrequent tumor with a wide variety of histological presentations even as indolent as pilocytic astrocytoma, which should be considered in spinal cord tumors, especially if there are clinical, histological, or radiological data that suggest aggressiveness. On the other hand, the fast progression led to the loss of complete neurological function distal to the tumor, in spinal tumors could explain a not so poor prognosis as it is in functionally and vital structures.

15.
Nat Commun ; 12(1): 4555, 2021 Jul 27.
Article in English | MEDLINE | ID: mdl-34315883

ABSTRACT

Current-induced spin-orbit torques (SOTs) are of interest for fast and energy-efficient manipulation of magnetic order in spintronic devices. To be deterministic, however, switching of perpendicularly magnetized materials by SOT requires a mechanism for in-plane symmetry breaking. Existing methods to do so involve the application of an in-plane bias magnetic field, or incorporation of in-plane structural asymmetry in the device, both of which can be difficult to implement in practical applications. Here, we report bias-field-free SOT switching in a single perpendicular CoTb layer with an engineered vertical composition gradient. The vertical structural inversion asymmetry induces strong intrinsic SOTs and a gradient-driven Dzyaloshinskii-Moriya interaction (g-DMI), which breaks the in-plane symmetry during the switching process. Micromagnetic simulations are in agreement with experimental results, and elucidate the role of g-DMI in the deterministic switching processes. This bias-field-free switching scheme for perpendicular ferrimagnets with g-DMI provides a strategy for efficient and compact SOT device design.

16.
Nat Commun ; 12(1): 3828, 2021 Jun 22.
Article in English | MEDLINE | ID: mdl-34158511

ABSTRACT

There is accelerating interest in developing memory devices using antiferromagnetic (AFM) materials, motivated by the possibility for electrically controlling AFM order via spin-orbit torques, and its read-out via magnetoresistive effects. Recent studies have shown, however, that high current densities create non-magnetic contributions to resistive switching signals in AFM/heavy metal (AFM/HM) bilayers, complicating their interpretation. Here we introduce an experimental protocol to unambiguously distinguish current-induced magnetic and nonmagnetic switching signals in AFM/HM structures, and demonstrate it in IrMn3/Pt devices. A six-terminal double-cross device is constructed, with an IrMn3 pillar placed on one cross. The differential voltage is measured between the two crosses with and without IrMn3 after each switching attempt. For a wide range of current densities, reversible switching is observed only when write currents pass through the cross with the IrMn3 pillar, eliminating any possibility of non-magnetic switching artifacts. Micromagnetic simulations support our findings, indicating a complex domain-mediated switching process.

17.
Sci Rep ; 11(1): 8504, 2021 04 19.
Article in English | MEDLINE | ID: mdl-33875725

ABSTRACT

Tetherless sensors have long been positioned to enable next generation applications in biomedical, environmental, and industrial sectors. The main challenge in enabling these advancements is the realization of a device that is compact, robust over time, and highly efficient. This paper presents a tetherless optical tag which utilizes optical energy harvesting to realize scalable self-powered devices. Unlike previous demonstrations of optically coupled sensor nodes, the device presented here amplifies signals and encodes data on the same optical beam that provides its power. This optical interrogation modality results in a highly efficient data link. These optical tags support data rates up to 10 Mb/s with an energy consumption of ~ 3 pJ/bit. As a proof-of-concept application, the optical tag is combined with a spintronic microwave detector based on a magnetic tunnel junction (MTJ). We used this hybrid opto-spintronic system to perform self-powered transduction of RF waves at 1 GHz to optical frequencies at ~ 200 THz, while carrying an audio signal across (see Supplementary Data for audio files).

18.
Front Neurol ; 12: 632036, 2021.
Article in English | MEDLINE | ID: mdl-33692744

ABSTRACT

SARS-CoV2 infection can lead to a prothrombotic state. Large vessel occlusion, as well as malignant cerebral stroke have been described in COVID-19 patients. In the following months, given the increase in COVID-19 cases, an increase in malignant cerebral SARS-CoV2 associated strokes are expected. The baseline situation of the patients as well as the risk of evolution to a serious disease due to the virus, depict a unique scenario. Decompressive craniectomy is a life-saving procedure indicated in patients who suffer a malignant cerebral stroke; however, it is unclear whether the same eligibility criteria should be used for patients with COVID-19. To our knowledge seven cases of decompressive craniectomy and malignant cerebral stroke have been described to date. We report on a 39-year-old female with no major risk factors for cerebrovascular disease, apart from oral contraception, and mild COVID-19 symptoms who suffered from left hemispheric syndrome. The patient underwent endovascular treatment with stenting and afterward decompressive craniectomy due to a worsening neurological status with unilateral unreactive mydriasis. We present the case and provide a comprehensive review of the available literature related to the surgical treatment for COVID-19 associated malignant strokes, to establish whether the same eligibility criteria for non-COVID-19 associated strokes should be used. Eight patients, including our case, were surgically managed due to malignant cerebral stroke. Seven of these patients received decompressive craniectomy, and six of them met the eligibility criteria of the current stroke guidelines. The mortality rate was 33%, similar to that described in non-COVID-19 cases. Two patients had a left middle cerebral artery (MCA) and both survived after decompressive craniectomy. Our results support that decompressive craniectomy, using the current stroke guidelines, should be considered an effective life-saving treatment for COVID-19-related malignant cerebral strokes.

19.
Turk Neurosurg ; 31(2): 217-222, 2021.
Article in English | MEDLINE | ID: mdl-33624274

ABSTRACT

AIM: To demonstrate the microsurgical procedures, and to evaluate the feasibility of living models of experimental neurovascular training by developing new complex vascular exercises mimicking the most common intracranial aneurysms. MATERIAL AND METHODS: The procedures were performed under a Zeiss (OPMI pico f170) microscope using basic microsurgery instruments, 10/0 Nylon and blue Polypropylene micro-sutures. We selected adult albino Wistar rats weighing between 258 and 471g each. Seven different aneurysm types were created using carotid, jugular, cava, aorta and femoral vessels. RESULTS: Seven types of aneurysm were designed and created in the rat with a high-medium successful rate. There are differences in terms of realism and the difficulty of performance, according to the different types: lateral wall, bifurcation, top of the basilar, fusiform, fusiform + involved branch, Anterior Communicating Artery (ACoA) and giant. The steps and technical issues to produce these exercises are described. CONCLUSION: We show the feasibility of creating several types of aneurysm using different vessels in a rodent model. Training on these models help to improve microsurgical skills, allowing safe practice for neurosurgeons in all stages of their career.


Subject(s)
Disease Models, Animal , Intracranial Aneurysm/surgery , Microaneurysm/surgery , Microsurgery/education , Neurosurgical Procedures/education , Vascular Surgical Procedures/education , Animals , Anterior Cerebral Artery/pathology , Anterior Cerebral Artery/surgery , Circle of Willis/pathology , Circle of Willis/surgery , Female , Humans , Intracranial Aneurysm/pathology , Microaneurysm/pathology , Microsurgery/methods , Neurosurgical Procedures/methods , Rats , Rats, Wistar , Rodentia , Vascular Surgical Procedures/methods
20.
J Strength Cond Res ; 35(4): 902-909, 2021 Apr 01.
Article in English | MEDLINE | ID: mdl-33555833

ABSTRACT

ABSTRACT: Nuell, S, Illera-Domínguez, V, Carmona, G, Macadam, P, Lloret, M, Padullés, JM, Alomar, X, and Cadefau, JA. Hamstring muscle volume as an indicator of sprint performance. J Strength Cond Res 35(4): 902-909, 2021-This study aimed to compare mechanical properties and performance during sprinting, as well as thigh muscle volumes (MVs), between national-level sprinters and physically active males. In addition, the relationships between thigh MVs and sprint mechanical properties and performance were investigated. Seven male sprinters and 9 actives performed maximal-effort 40-m sprints. Instantaneous velocity was measured by radar to obtain theoretical maximum force (F0), the theoretical maximum velocity (V0), and the maximum power (Pmax). For MV assessment, series of cross-sectional images of each subject's thigh were obtained by magnetic resonance imaging for each of the quadriceps and hamstring muscles and the adductor muscle group. Sprinters were faster over 10 m (7%, effect size [ES] = 2.12, p < 0.01) and 40 m (11%, ES = 3.68, p < 0.01), with significantly higher V0 (20%, ES = 4.53, p < 0.01) and Pmax (28%, ES = 3.04, p < 0.01). Sprinters had larger quadriceps (14%, ES = 1.12, p < 0.05), adductors (23%, ES = 1.33, p < 0.05), and hamstrings (32%, ES = 2.11, p < 0.01) MVs than actives. Hamstrings MV correlated strongly with 40-m sprint time (r = -0.670, p < 0.01) and V0 (r = 0.757, p < 0.01), and moderately with Pmax (r = 0.559, p < 0.05). Sprinters were significantly faster and had greater V0 and Pmax than active males. Larger MVs were found in sprinters' thighs, especially in the hamstring musculature, and strong correlations were found between hamstring MV and sprint mechanical properties and sprint performance.


Subject(s)
Athletic Performance , Hamstring Muscles , Running , Cross-Sectional Studies , Hamstring Muscles/diagnostic imaging , Humans , Male , Thigh
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