1.
An R Acad Nac Med (Madr)
; 118(3): 633-52, 2001.
Article
in Spanish
| MEDLINE
| ID: mdl-11783043
ABSTRACT
The authors present a personal interpretation of the pathogeny of prionic processes, showing the role played by heredity. They also present the very surprising fact that a protein codified by a mutant gene can act as transmissible agent in a serious illness opening new chapters to the pathology of a series of important diseases. This is a completely new perspective in the biology.
Subject(s)
PrPC Proteins/genetics , Prion Diseases/genetics , Prions/genetics , Age Factors , Aged , Animals , Cattle , Codon , Creutzfeldt-Jakob Syndrome/genetics , Creutzfeldt-Jakob Syndrome/pathology , Cricetinae , Disease Models, Animal , Exons , Genetic Predisposition to Disease , Humans , Mice , Mice, Transgenic , Mutation , Polymorphism, Genetic , PrPC Proteins/biosynthesis , PrPC Proteins/metabolism , Prion Diseases/pathology , Prion Diseases/transmission , Rats , Scrapie/genetics , Sheep , Synapses/metabolism , Time Factors
2.
Int Arch Occup Environ Health
; 72(6): 345-50, 1999 Sep.
Article
in English
| MEDLINE
| ID: mdl-10473834
