1.
Br J Cancer
; 102(1): 23-6, 2010 Jan 05.
Article
in English
| MEDLINE
| ID: mdl-19920831
ABSTRACT
BACKGROUND: There is a need for simple imaging parameters capable of predicting therapeutic outcome. METHODS: This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (E(F)) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS). RESULTS: Tumours with high E(F) had a significantly poorer probability of DFS than those with low E(F) (P=0.011). INTERPRETATION: E(F) is a simple imaging biomarker that should be studied further in a multi-centre setting.
Subject(s)
Carcinoma, Squamous Cell/blood supply , Contrast Media , Gadolinium DTPA , Image Processing, Computer-Assisted/methods , Magnetic Resonance Imaging/methods , Neovascularization, Pathologic/pathology , Uterine Cervical Neoplasms/blood supply , Adenocarcinoma/blood supply , Adenocarcinoma/radiotherapy , Adult , Aged , Aged, 80 and over , Carcinoma, Adenosquamous/blood supply , Carcinoma, Adenosquamous/radiotherapy , Carcinoma, Squamous Cell/mortality , Carcinoma, Squamous Cell/radiotherapy , Disease-Free Survival , Female , Follow-Up Studies , Humans , Image Processing, Computer-Assisted/statistics & numerical data , Kaplan-Meier Estimate , Middle Aged , Neoplasm Metastasis , Neoplasm Recurrence, Local/epidemiology , Neoplasm, Residual , Retrospective Studies , Uterine Cervical Neoplasms/mortality , Uterine Cervical Neoplasms/radiotherapy
2.
Nurs Res
; 17(5): 388-95, 1968.
Article
in English
| MEDLINE
| ID: mdl-5186882