ABSTRACT
Line-field confocal optical coherence tomography (LC-OCT) can help the clinical diagnosis of skin diseases. The present study aimed to evaluate the sensitivity, specificity, and diagnostic accuracy of LC-OCT for the diagnosis of the most frequent non-melanoma skin cancers (NMSCs), i.e., basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Comparing LC-OCT diagnostic performances with those of dermoscopy, histopathological examination was used as a gold standard. For every study endpoint, the diagnostic ability of LC-OCT revealed superiority over the dermoscopic examination. In particular, a significant increase in specificity was observed. Sensitivity, specificity, and diagnostic accuracy of dermoscopy and LC-OCT for the diagnosis of malignancy were, respectively, 0.97 (CI 0.94-0.99), 0.43 (CI 0.36-0.51), and 0.77 (CI 0.72-0.81) for dermoscopy and 0.99 (CI 0.97-1.00), 0.90 (CI 0.84-0.94), and 0.96 (CI 0.93-0.97) for LC-OCT. The positive predictive value (PPV) resulted in 0.74 (CI 0.69-0.78) for dermoscopy and 0.94 (CI 0.91-0.97) for LC-OCT, and the negative predictive value (NPV) was 0.89 (CI 0.81-0.95) for dermoscopy and 0.98 (CI 0.95-1.00) for LC-OCT. Finally, our real-life study showed a potentially important role of LC-OCT in the non-invasive diagnosis of NMSCs, especially BCC. The real-time imaging technique could spare unnecessary biopsies with an increased sensitivity, a much higher specificity, and better accuracy than clinical assessment with dermoscopy alone.
Subject(s)
Carcinoma, Basal Cell , Skin Neoplasms , Humans , Tomography, Optical Coherence/methods , Sensitivity and Specificity , Dermoscopy/methods , Skin Neoplasms/diagnostic imaging , Skin Neoplasms/pathology , Carcinoma, Basal Cell/diagnostic imaging , Carcinoma, Basal Cell/pathologyABSTRACT
Line-field confocal optical coherence tomography (LC-OCT) is a new non-invasive dermatological imaging device. We summarized the available data on the use of LC-OCT for inflammatory and infectious diseases. In February 2023, we searched for all articles concerning the use of LC-OCT in inflammatory and infectious diseases. A total number of 14 papers were found and evaluated, and relevant information was extracted. LC-OCT can reveal architectural changes in the skin. Inflammatory cells are barely visible. It can highlight the level of fluid accumulation, the thickness of different epidermal layers, and the presence of ''foreign bodies'' such as parasites.
