1.
Chem Commun (Camb)
; 53(81): 11201-11204, 2017 Oct 10.
Article
in English
| MEDLINE
| ID: mdl-28956556
ABSTRACT
A TfOH-catalyzed highly diastereoselective Michael addition/ketalization sequence of 3-hydroxyoxindoles and ortho-hydroxychalcones was developed, leading to biologically important bridged ketal spirooxindoles in moderate to excellent yields. Moreover, some chemical transformations were carried out to further extend the structural complexity and diversity.
2.
J Org Chem
; 82(11): 5669-5677, 2017 06 02.
Article
in English
| MEDLINE
| ID: mdl-28472885
ABSTRACT
An efficient Cu(OTf)2-catalyzed Friedel-Crafts alkylation/cyclizaiton sequence of 3-substituted indoles with isatin-derived oxodienes was developed, and a series of structurally complex and diverse pyrrolo[1,2-a]indole spirooxindoles were first obtained in up to 99% yields. This protocol proved to be quite general and was also robust for the synthesis of 9H-pyrrolo[1,2-a]indoles.