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1.
Fitoterapia ; 175: 105963, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38631598

ABSTRACT

Four new monomeric sorbicillinoids, trichillinoids A - D (1-4), along with two known dimeric sorbicillinoids (5 and 6), and five known monomeric sorbicillinoids (7-11), were obtained from the marine-fish-derived fungus Trichoderma sp. G13. They were structurally characterized on the basis of comprehensive spectroscopic investigations (NMR, HRESIMS, and ECD). Compounds 1-4 displayed moderate anti-inflammatory activities, according to inhibiting the production of NO in RAW264.7 cells activated with IC50 values ranging from 14 to 20 µM.


Subject(s)
Anti-Inflammatory Agents , Trichoderma , Mice , Animals , RAW 264.7 Cells , Molecular Structure , Anti-Inflammatory Agents/pharmacology , Anti-Inflammatory Agents/isolation & purification , Trichoderma/chemistry , Nitric Oxide/metabolism , Fishes/microbiology , China
2.
J Nat Prod ; 86(4): 739-750, 2023 04 28.
Article in English | MEDLINE | ID: mdl-36888988

ABSTRACT

Eleven new pyridone alkaloids, penicipyridones A-K (1-11), and three new tetramic acids, tolypocladenols D-F (12-14), were isolated from rice media cultures of the marine-derived fungus Penicillium oxalicum QDU1. Their structures, including absolute configurations, were determined by comprehensive analyses of spectroscopic data, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction data. Interestingly, several of the penicipyridones undergo interconversions between hydroxy and methoxy groups at C-4 in acidic MeOH solution. Furthermore, in an acidic aqueous solution, OH-4 could be replaced by diverse substituent groups. Compounds 1, 4, 5, 8, 10, 11, and 14 exhibited moderate inhibitory effects on NO production in the LPS-induced RAW264.7 macrophages, with IC50 values ranging from 9.2 to 19 µM.


Subject(s)
Alkaloids , Penicillium , Alkaloids/chemistry , Penicillium/chemistry , Fungi , Pyridones/chemistry , Molecular Structure
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