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Bull Environ Contam Toxicol ; 79(4): 472-7, 2007 Oct.
Article in English | MEDLINE | ID: mdl-17712503

ABSTRACT

Polyunsaturated fatty acids (PUFA) in milk are vital for normal growth and development of infant mammals. Changes in fatty acid composition were observed in milk fat from goats dosed with perchlorate (0.1 and 1 mg/kg body weight/day) for 31 days, but the effect was not persistent. Adaptation may be induced in these goats to compensate for the perchlorate effect. In an analysis of fatty acid composition in human milk samples, a weak negative correlation was observed between perchlorate concentrations and total PUFA in 38 human milk samples.


Subject(s)
Fatty Acids, Unsaturated/analysis , Goats/metabolism , Milk, Human/drug effects , Perchlorates/toxicity , Animals , Body Mass Index , Breast Feeding , Dose-Response Relationship, Drug , Fatty Acids, Unsaturated/chemistry , Fatty Acids, Unsaturated/metabolism , Female , Humans , Infant , Infant, Newborn , Milk, Human/chemistry , Milk, Human/metabolism , Perchlorates/metabolism , Pregnancy , Time Factors
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