Influence of interpersonal distance on collaborative performance in the joint Simon task-An fNIRS-based hyperscanning study.

Collaboration is a critical skill in everyday life. It has been suggested that collaborative performance may be influenced by social factors such as interpersonal distance, which is defined as the perceived psychological distance between individuals. Previous literature has reported that close interpersonal distance may promote the level of self-other integration between interacting members, and in turn, enhance collaborative performance. These studies mainly focused on interdependent collaboration, which requires high levels of shared representations and self-other integration. However, little is known about the effect of interpersonal distance on independent collaboration (e.g., the joint Simon task), in which individuals perform the task independently while the final outcome is determined by the parties. To address this issue, we simultaneously measured the frontal activations of ninety-four pairs of participants using a functional near-infrared spectroscopy (fNIRS)-based hyperscanning technique while they performed a joint Simon task. Behavioral results showed that the Joint Simon Effect (JSE), defined as the RT difference between incongruent and congruent conditions indicating the level of self-other integration between collaborators, was larger in the friend group than in the stranger group. Consistently, the inter-brain neural synchronization (INS) across the dorsolateral and medial parts of the prefrontal cortex was also stronger in the friend group. In addition, INS in the left dorsolateral prefrontal cortex negatively predicted JSE only in the friend group. These results suggest that close interpersonal distance may enhance the shared mental representation among collaborators, which in turn influences their collaborative performance.

Effects of emotion and sex difference on item-method directed forgetting.

It is crucial to remember or forget others' faces in daily life. People can intentionally forget things they wish to forget, a phenomenon called directed forgetting (DF). This study examined the effects of stimuli's emotions and sex differences in participants and stimuli on DF. We used happy and angry faces as the items in a typical item-method paradigm and conducted three behavioral experiments. In Experiment 1, we recruited 60 participants to examine how emotions of stimuli and sex differences in participants and stimuli affected DF. In Experiment 2, we recruited 60 female participants and manipulated the durations of items presented during the study phase to examine whether the selective rehearsal theory was held. In Experiment 3, we recruited 50 female participants and attached recognition cues to the items presented during the test phase to examine whether the inhibitory control theory was held. We treated the sex of participants in Experiment 1, the durations of items presented during the study phase in Experiment 2 as the between-subject factors, and emotion and sex of stimuli as the with-subject factors. We conducted the mixed-design ANOVA for corrected hit rate, sensitivity, and bias based on the signal detection theory. As a result, we found that DF occurred easily for male participants, whereas not for female participants because of females' superior memorial performances and stronger sensitivities. Furthermore, we found that female participants owned the best and worst recognition rates for angry female faces and happy male faces, respectively. Our results supported the selective rehearsal theory, suggesting manipulations during the study phase had the potential to help females forget what they wished to forget. We presumed that psychologists and therapists should pay attention to the roles of sex difference in twofold, self and others, when studying people's memory and forgetting. Furthermore, the sensitivity of self and the emotion of others should be considered as well.

The Underlying neural mechanisms of interpersonal situations on collaborative ability: A hyperscanning study using functional near-infrared spectroscopy.

The collaborative ability to coordinate an individual with others is critical to performance of joint actions. Prior studies found that different types of interpersonal situations have more or less impact on the collaborative ability of joint actions, but the results are controversial. To clarify the influence of interpersonal situations on collaborative ability, we adopted the joint Simon task, a choice-reaction task that two people perform together. Functional near-infrared spectroscopy (fNIRS) was used to study the neural mechanisms of interpersonal situations on collaborative ability and task performance under payoffs that fostered competition or cooperation. The fNIRS results showed that significant inter-brain neural synchronization (INS) occurred in the bilateral inferior parietal lobule (IPL) for both situations. Moreover, for the competition situation, the pairs also shown a significant INS in the right IPL. These results imply that the bilateral IPL is involved in cooperation and competition due to involvement of common concern and understanding of intention. The right IPL may be more crucial for competition because of the psychological resources involved in distinguishing self and others. Eventually, the INS in competition was better than in the other situations, correlating with higher performance of the joint task as well.

Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation.

Interactions between EphB4 receptor tyrosine kinases and their membrane-bound ephrin-B2 ligands on apposed cells play a regulatory role in neural stem cell differentiation. With both receptor and ligand constrained to move within the membranes of their respective cells, this signaling system inevitably experiences spatial confinement and mechanical forces in conjunction with receptor-ligand binding. In this study, we reconstitute the EphB4-ephrin-B2 juxtacrine signaling geometry using a supported-lipid-bilayer system presenting laterally mobile and monomeric ephrin-B2 ligands to live neural stem cells. This experimental platform successfully reconstitutes EphB4-ephrin-B2 binding, lateral clustering, downstream signaling activation, and neuronal differentiation, all in a configuration that preserves the spatiomechanical aspects of the natural juxtacrine signaling geometry. Additionally, the supported bilayer system allows control of lateral movement and clustering of the receptor-ligand complexes through patterns of physical barriers to lateral diffusion fabricated onto the underlying substrate. The results from this study reveal a distinct spatiomechanical effect on the ability of EphB4-ephrin-B2 signaling to induce neuronal differentiation. These observations parallel similar studies of the EphA2-ephrin-A1 system in a very different biological context, suggesting that such spatiomechanical regulation may be a common feature of Eph-ephrin signaling.

A supramolecular strategy for self-mobile adsorption sites in affinity membrane.

Disclosed here is the design of a novel supramolecular membrane with self-mobile adsorption sites for biomolecules purification. In the 3D micropore channels of membrane matrix, the ligands are conjugated onto the cyclic compounds in polyrotaxanes for protein adsorption. During membrane filtration, the adsorption sites can rotate and/or slide along the axial chain, which results in the enhanced adsorption capacity. The excellent performance of supra-molecular membrane is related with the dynamic working manner of adsorption sites, which plays a crucial role on avoiding spatial mismatching and short-circuit effect. The supra-molecular strategy described here has general suggestions for the "sites" involved technologies such as catalysis, adsorption, and sensors, which is of broad interest.

Pan-neuronal maturation but not neuronal subtype differentiation of adult neural stem cells is mechanosensitive.

Most past studies of the biophysical regulation of stem cell differentiation have focused on initial lineage commitment or proximal differentiation events. It would be valuable to understand whether biophysical inputs also influence distal endpoints more closely associated with physiological function, such as subtype specification in neuronal differentiation. To explore this question, we cultured adult neural stem cells (NSCs) on variable stiffness ECMs under conditions that promote neuronal fate commitment for extended time periods to allow neuronal subtype differentiation. We find that ECM stiffness does not modulate the expression of NeuroD1 and TrkA/B/C or the percentages of pan-neuronal, GABAergic, or glutamatergic neuronal subtypes. Interestingly, however, an ECM stiffness of 700 Pa maximizes expression of pan-neuronal markers. These results suggest that a wide range of stiffnesses fully permit pan-neuronal NSC differentiation, that an intermediate stiffness optimizes expression of pan-neuronal genes, and that stiffness does not impact commitment to particular neuronal subtypes.

Sulfur removal from fuel using zeolites/polyimide mixed matrix membrane adsorbents.

A novel membrane adsorption process was proposed for the sulfur removal from fuels. The mixed matrix membranes (MMMs) adsorbents composed of polyimide (PI) and various Y zeolites were prepared. By the detailed characterization of FT-IR, morphology, thermal and mechanical properties of MMMs adsorbents, combining the adsorption and desorption behavior research, the process-structure-function relationship was discussed. Field-emission scanning electron microscope (FESEM) images show that the functional particles are incorporated into the three-dimensional network structure. MMMs adsorbents with 40% of zeolites content possess better physical properties, which was confirmed by mechanical strength and thermo stability analysis. Influence factors including post-treatment, content of incorporated zeolites, adsorption time, temperature, initial sulfur concentration as well as sulfur species on the adsorption performance of MMMs adsorbents have been evaluated. At 4 wt.% zeolites content, adsorption capacity for NaY/PI, AgY/PI and CeY/PI MMMs adsorbents come to 2.0, 7.5 and 7.9 mg S/g, respectively. And the regeneration results suggest that the corresponding spent membranes can recover about 98%, 90% and 70% of the desulfurization capacity, respectively. The distinct adsorption and desorption behavior of MMMs adsorbents with various functional zeolites was markedly related with their various binding force and binding mode with sulfur compounds.

Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology.

Glioblastoma Multiforme (GBM) is a malignant astrocytic tumor associated with low survival rates because of aggressive infiltration of tumor cells into the brain parenchyma. Expression of the actin binding protein alpha-actinin has been strongly correlated with the invasive phenotype of GBM in vivo. To probe the cellular basis of this correlation, we have suppressed expression of the nonmuscle isoforms alpha-actinin-1 and alpha-actinin-4 and examined the contribution of each isoform to the structure, mechanics, and motility of human glioma tumor cells in culture. While subcellular localization of each isoform is distinct, suppression of either isoform yields a phenotype that includes dramatically reduced motility, compensatory upregulation and redistribution of vinculin, reduced cortical elasticity, and reduced ability to adapt to changes in the elasticity of the extracellular matrix (ECM). Mechanistic studies reveal a relationship between alpha-actinin and non-muscle myosin II in which depletion of either alpha-actinin isoform reduces myosin expression and maximal cell-ECM tractional forces. Our results demonstrate that both alpha-actinin-1 and alpha-actinin-4 make critical and distinct contributions to cytoskeletal organization, rigidity-sensing, and motility of glioma cells, thereby yielding mechanistic insight into the observed correlation between alpha-actinin expression and GBM invasiveness in vivo.

Effective Fresnel number and the focal shifts of focused partially coherent beams.

We define the effective Fresnel number of the cylindrical lens illuminated by a plane wave or Schell-model beams. On the basis of the concept of the effective Fresnel number, the focusing properties of the cylindrical lens illuminated by the Schell-model beam are investigated in a simple way. It is shown that the relative focal shift can be evaluated by an analytical formulation, which is expressed as a function of the effective Fresnel number. To evaluate our approach, we make the comparison between the results obtained by our method and the numerical calculation based on the diffraction integral. The results indicate that we can simply and exactly evaluate the focal shifts with our method.

Generation of adjustable partially coherent bottle beams by use of an axicon-lens system.

We report, what is to our knowledge, the first experimental realization of partially coherent bottle beams. It is shown that partially coherent bottle beams can be achieved by the focusing of partially coherent light with an axicon-lens system. The influence of the spatial coherence of the incident partially coherent light and other parameters, such as the radius of the limiting aperture of the axicon and the distance between the axicon and the lens, on the size of the bottle beams is investigated. We find that the longer the spatial coherence length, the larger the size of the resultant bottle beams. This dependence of the size of the bottle beams on the spatial coherence of the incident light provides a facile approach for generating adjustable partially coherent bottle beams. This kind of partially coherent bottle beam may have applications in atom optics, such as in atom trapping and atom guiding, etc.