Triiodothyronine (T3) suppresses hepatic tumorigenesis and development by inhibiting the phosphorylation of ERK.

The effect of triiodothyronine (T3) on the phosphorylation of ERK and the occurrence and development of hepatocellular carcinoma (HCC) is controversial and remains to be clarified. In the present study, both in vitro (hepatoma cell lines) and in vivo (wild-type mice [WT] and mouse models of HCC [HrasG12Vand KrasG12Dtransgenic mice (Hras-Tg and Kras-Tg)]) systems were used to investigate the effect of T3 on p-ERK and hepatocarcinogenesis. The results showed that, in vitro, T3 treatment elevated the levels of p-ERK in hepatoma cells within 30 min. However, p-ERK levels returned to normal after 1 h with no significant effects on cellular proliferation or apoptosis. Interestingly, in vivo, T3 induced early rapid and transient activation of ERK and later persistent downregulation of p-ERK in liver tissues of WT. In Hras-Tg, liver weight, liver/body weight ratio, hepatic tumor numbers and sizes were significantly reduced withT3treatment compared with the untreated group. Furthermore, the levels of albumin, HrasG12V, and p-ERK in hepatic precancerous and tumor tissues were all significantly downregulated with T3 treatment; however, the levels of endogenous Hras were not affected. In WT, T3 also induced downregulation of Albumin in liver tissues, but without influence on the expression of endogenous Hras and p-MEK. Especially, the inhibitory effect of T3 on p-ERK and hepatic tumorigenesis and development without influence on the levels of KrasG12D and p-MEK was further confirmed in Kras-Tg. In conclusion, T3 suppresses hepatic tumorigenesis and development by independently and substantially inhibiting the phosphorylation of ERK in vivo.

Reconfigurable add-drop filter based on an antisymmetric multimode photonic crystal nanobeam cavity in a silicon waveguide.

We have designed and demonstrated a reconfigurable channel add-drop filter (ADF) based on an antisymmetric multimode photonic crystal nanobeam cavity (AM-PCNC) in a silicon waveguide. The proposed AM-PCNC can realize channel add-drop filtering by selectively filtering and reflecting the fundamental mode (TE0) and 1st-order mode (TE1) in the multimode waveguide. A high-performance add-drop filter has been demonstrated with a high extinction ratio of 28.2 dB and an insertion loss of 0.18 dB. Meanwhile, the reconfigurable add-dropping has been realized by heating the nanobeam cavity to tune the filtering wavelength. A tuning efficiency of 0.464 nm/mW was measured. The rising and falling time are ∼6.5 µs and ∼0.6 µs, respectively, which are at microsecond time scale. The footprint of the involved nanobeam cavity is only 16.5 µm2. The device can potentially provide an integrated component for optical switch array, routers, and wavelength-division multiplexing in the optical networks.

Transition metal-free approach to azafluoranthene scaffolds by aldol condensation/[1+2+3] annulation tandem reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes.

A transition metal-free aldol condensation/[1+2+3] annulation reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes has been developed for the general synthesis of azafluoranthenes. This domino reaction enables successive formation of three new bonds and two rings from readily accessible starting materials in a single operation. Furthermore, this methodology can also be utilized to construct chromeno[4,3-c]pyridines and benzo[c][2,6]naphthyridines in moderate yields.

Suspended slotted photonic crystal cavities for high-sensitivity refractive index sensing.

We present the design, fabrication, and characterization of a suspended slotted photonic crystal (SSPhC) cavity sensor based on the silicon-on-insulator platform. The sensing performance can be dramatically enhanced by the optimized SSPhC cavity as most of the light energy can be distributed in the low index region (∼57%). By measuring the spectrum response of the cavity sensor immersed in NaCl solutions with different mass concentrations, an ultra-high sensitivity around 656 nm/RIU has been experimentally demonstrated. Furthermore, the whole size of the cavity sensor (including the grating couplers) is 320 × 40 µm2, making the high-sensitivity device attractive for the realization of large-scale multi-channel on-chip sensors.

Low-index-mode photonic crystal nanobeam cavity for refractive index sensing at the 2 µm wavelength band.

We present the design, fabrication, and characterization of a one-dimensional photonic crystal (1D-PhC) low-index-mode nanobeam cavity on the silicon-on-insulator platform for refractive index sensing at the 2 µm wavelength band. A Q-factor of 4.35×105 and an effective mode volume of Veff∼1.95(λ/nSi)3 are theoretically achieved. The measured transmission spectrum of the device immersed in NaCl solutions with different mass concentrations demonstrates a sensitivity of 326.1 nm/RIU and a Q-factor of ∼1144.