1.
Org Lett
; 25(43): 7841-7846, 2023 Nov 03.
Article
in English
| MEDLINE
| ID: mdl-37862469
ABSTRACT
A dearomatization/spiroannulation process has been successfully achieved between simple halophenols and α,ß-unsaturated olefins under mild reaction conditions. This transformation addresses the chemoselectivity issue in the dearomatizative transformation of phenol scaffolds (6π-electron) caused by the SEAr process, enabling the construction of versatile cyclohexadienone frameworks containing contiguous quaternary all-carbon centers in high yields. Further studies have provided valuable insights into the process, revealing that debromination/spiroannulation occurs through the SRN1 pathway.