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1.
Comput Med Imaging Graph ; 113: 102345, 2024 04.
Article in English | MEDLINE | ID: mdl-38330636

ABSTRACT

Robust and interpretable image reconstruction is central to imageology applications in clinical practice. Prevalent deep networks, with strong learning ability to extract implicit information from data manifold, are still lack of prior knowledge introduced from mathematics or physics, leading to instability, poor structure interpretability and high computation cost. As to this issue, we propose two prior knowledge-driven networks to combine the good interpretability of mathematical methods and the powerful learnability of deep learning methods. Incorporating different kinds of prior knowledge, we propose subband-adaptive wavelet iterative shrinkage thresholding networks (SWISTA-Nets), where almost every network module is in one-to-one correspondence with each step involved in the iterative algorithm. By end-to-end training of proposed SWISTA-Nets, implicit information can be extracted from training data and guide the tuning process of key parameters that possess mathematical definition. The inverse problems associated with two medical imaging modalities, i.e., electromagnetic tomography and X-ray computational tomography are applied to validate the proposed networks. Both visual and quantitative results indicate that the SWISTA-Nets outperform mathematical methods and state-of-the-art prior knowledge-driven networks, especially with fewer training parameters, interpretable network structures and well robustness. We assume that our analysis will support further investigation of prior knowledge-driven networks in the field of ill-posed image reconstruction.


Subject(s)
Algorithms , Image Processing, Computer-Assisted , Learning
2.
IEEE Trans Med Imaging ; 40(5): 1329-1339, 2021 05.
Article in English | MEDLINE | ID: mdl-33493113

ABSTRACT

Inverse problems are essential to imaging applications. In this letter, we propose a model-based deep learning network, named FISTA-Net, by combining the merits of interpretability and generality of the model-based Fast Iterative Shrinkage/Thresholding Algorithm (FISTA) and strong regularization and tuning-free advantages of the data-driven neural network. By unfolding the FISTA into a deep network, the architecture of FISTA-Net consists of multiple gradient descent, proximal mapping, and momentum modules in cascade. Different from FISTA, the gradient matrix in FISTA-Net can be updated during iteration and a proximal operator network is developed for nonlinear thresholding which can be learned through end-to-end training. Key parameters of FISTA-Net including the gradient step size, thresholding value and momentum scalar are tuning-free and learned from training data rather than hand-crafted. We further impose positive and monotonous constraints on these parameters to ensure they converge properly. The experimental results, evaluated both visually and quantitatively, show that the FISTA-Net can optimize parameters for different imaging tasks, i.e. Electromagnetic Tomography (EMT) and X-ray Computational Tomography (X-ray CT). It outperforms the state-of-the-art model-based and deep learning methods and exhibits good generalization ability over other competitive learning-based approaches under different noise levels.


Subject(s)
Algorithms , Image Processing, Computer-Assisted , Neural Networks, Computer , Tomography, X-Ray Computed
3.
IEEE Trans Med Imaging ; 39(12): 4102-4112, 2020 12.
Article in English | MEDLINE | ID: mdl-32746151

ABSTRACT

Imaging the bio-impedance distribution of the brain can provide initial diagnosis of acute stroke. This paper presents a compact and non-radiative tomographic modality, i.e. multi-frequency Electromagnetic Tomography (mfEMT), for the initial diagnosis of acute stroke. The mfEMT system consists of 12 channels of gradiometer coils with adjustable sensitivity and excitation frequency. To solve the image reconstruction problem of mfEMT, we propose an enhanced Frequency-Constrained Sparse Bayesian Learning (FC-SBL) to simultaneously reconstruct the conductivity distribution at all frequencies. Based on the Multiple Measurement Vector (MMV) model in the Sparse Bayesian Learning (SBL) framework, FC-SBL can recover the underlying distribution pattern of conductivity among multiple images by exploiting the frequency constraint information. A realistic 3D head model was established to simulate stroke detection scenarios, showing the capability of mfEMT to penetrate the highly resistive skull and improved image quality with FC-SBL. Both simulations and experiments showed that the proposed FC-SBL method is robust to noisy data for image reconstruction problems of mfEMT compared to the single measurement vector model, which is promising to detect acute strokes in the brain region with enhanced spatial resolution and in a baseline-free manner.


Subject(s)
Algorithms , Image Processing, Computer-Assisted , Stroke , Bayes Theorem , Humans , Stroke/diagnostic imaging , Tomography
4.
IEEE Trans Biomed Circuits Syst ; 13(1): 68-79, 2019 02.
Article in English | MEDLINE | ID: mdl-30418883

ABSTRACT

In this paper, the human body communication (HBC) and level crossing sampling (LCS) are combined to design electronics for a wearable electrocardiograph (ECG). The ECG signals acquired by capacitively coupled electrodes are sampled with LCS in place of conventional synchronous sampling. In order to transmit signals through HBC at low frequencies (100 kHz, 1 MHz), an electric field sensor with high input impedance is adopted as the front end of the HBC receiver. The HBC channel gain is enhanced by more than 30 dB with the electric field sensor. An LCS structure based on the send-on-delta concept is implemented with discrete components to convert the ECG signals into binary impulses. The converted impulses are modulated by an on-off keying modulator and then transmitted via the human body to the receiver. A prototype ECG waist belt is developed with commercially available components and experimentally evaluated. The results indicate that the acquired ECG waveforms exhibit good agreement with regular Ag/AgCl ECG methods. The heartbeat detection using a technique based on the Kadane's algorithm and the power consumption performance of the proposed system are also discussed.


Subject(s)
Algorithms , Communication , Electrocardiography , Human Body , Wearable Electronic Devices , Adult , Electricity , Humans , Male , Movement , Respiration , Signal Processing, Computer-Assisted , Wavelet Analysis , Young Adult
5.
Sensors (Basel) ; 18(9)2018 Aug 28.
Article in English | MEDLINE | ID: mdl-30154303

ABSTRACT

A prototype of an electrocardiogram (ECG) signal acquisition system with multiple unipolar capacitively coupled electrodes is designed and experimentally tested. Capacitively coupled electrodes made of a standard printed circuit board (PCB) are used as the sensing electrodes. Different from the conventional measurement schematics, where one single lead ECG signal is acquired from a pair of sensing electrodes, the sensing electrodes in our approaches operate in a unipolar mode, i.e., the biopotential signals picked up by each sensing electrodes are amplified and sampled separately. Four unipolar electrodes are mounted on the backrest of a regular chair and therefore four channel of signals containing ECG information are sampled and processed. It is found that the qualities of ECG signal contained in the four channel are different from each other. In order to pick up the ECG signal, an index for quality evaluation, as well as for aggregation of multiple signals, is proposed based on phase space reconstruction. Experimental tests are carried out while subjects sitting on the chair and clothed. The results indicate that the ECG signals can be reliably obtained in such a unipolar way.

6.
Sensors (Basel) ; 16(10)2016 Oct 13.
Article in English | MEDLINE | ID: mdl-27754381

ABSTRACT

In order to measure the nonlinear features of micromechanical resonators, a free damped oscillation method based on stair-stepped frequency sinusoidal pulse excitation is investigated. In the vicinity of the resonant frequency, a frequency stepping sinusoidal pulse sequence is employed as the excitation signal. A set of free vibration response signals, containing different degrees of nonlinear dynamical characteristics, are obtained. The amplitude-frequency curves of the resonator are acquired from the forced vibration signals. Together with a singular spectrum analysis algorithm, the instantaneous amplitudes and instantaneous frequencies are extracted by a Hilbert transform from the free vibration signals. The calculated Backbone curves, and frequency response function (FRF) curves are distinct and can be used to characterize the nonlinear dynamics of the resonator. Taking a Duffing system as an example, numerical simulations are carried out for free vibration response signals in cases of different signal-to-noise ratios (SNRs). The results show that this method displays better anti-noise performance than FREEVIB. A vibrating ring microgyroscope is experimentally tested. The obtained Backbone and FRF curves agree with those obtained by the traditional frequency sweeping method. As a test technique, the proposed method can also be used to for experimentally testing the dynamic characteristics of other types of micromechanical resonators.

7.
Sensors (Basel) ; 16(4)2016 04 22.
Article in English | MEDLINE | ID: mdl-27110787

ABSTRACT

In order to measure the impedance variation process in electrolyte solutions, a method of triangular waveform voltage excitation is investigated together with principal component analysis (PCA). Using triangular waveform voltage as the excitation signal, the response current during one duty cycle is sampled to construct a measurement vector. The measurement matrix is then constructed by the measurement vectors obtained from different measurements. After being processed by PCA, the changing information of solution impedance is contained in the loading vectors while the response current and noise information is contained in the score vectors. The measurement results of impedance variation by the proposed signal processing method are independent of the equivalent impedance model. The noise-induced problems encountered during equivalent impedance calculation are therefore avoided, and the real-time variation information of noise in the electrode-electrolyte interface can be extracted at the same time. Planar-interdigitated electrodes are experimentally tested for monitoring the KCl concentration variation process. Experimental results indicate that the measured impedance variation curve reflects the changing process of solution conductivity, and the amplitude distribution of the noise during one duty cycle can be utilized to analyze the contact conditions of the electrode and electrolyte interface.

8.
Article in English | MEDLINE | ID: mdl-15139549

ABSTRACT

This paper discusses the effect of transverse force on the performance of quartz crystal resonator (QXR) force sensors that use symmetrical incomplete circular QXRs as sensing elements. Based on Lee's vibration theory and the transverse force-induced stress distribution, frequency changes are derived. This result and finite element method (FEM) are applied to investigate the performance of two metal-quartz combined sensors under the action of transverse force. Analytical and experimental results show that transverse force affects the sensitivity and linearity of QXR force sensors.

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