ABSTRACT
BACKGROUND: Superficial chemical peels are frequently used in acne vulgaris treatment. Although glycolic acid (GA) has been widely used in clinical practice, its pH ranges from 0.08-2.75 and thus should be neutralized after application to avoid burns. OBJECTIVE: To evaluate treatment efficacy and safety of chemical peeling using buffered 50% GA (pH 3.0) + 0.5% salicylic acid (SA) solution that does not need to be neutralized in the treatment of acne vulgaris compared to the conventional peeling using Jessner's solution. METHODS: We performed a prospective, randomized, evaluator-blind, split-face clinical trial. Twenty patients were randomized by assigning one side of each patient's face to receive a 50% GA (pH 3.0) + 0.5% SA peel (GA side) and the other side to receive the Jessner's solution (Jessner's solution side). All patients underwent 2 sessions of treatment spaced 2 weeks apart. Lesion count, acne severity, subjective efficacy assessment, and side effects were evaluated. RESULTS: The total lesion count was significantly reduced for the GA and Jessner's solution sides (P < .001). However, there was no significant difference in the total lesion count, acne severity, or subjective efficacy assessment between the 2 sides (P > .05). The GA side had fewer side effects than the Jessner's solution side. CONCLUSION: The results of this study suggest that chemical peeling using the 50% GA (pH 3.0) + 0.5% SA solution can be as effective and convenient as the conventional peeling using Jessner's solution in the treatment of acne vulgaris and may show fewer adverse events than the conventional peeling.
Subject(s)
Acne Vulgaris/drug therapy , Chemexfoliation/methods , Ethanol/therapeutic use , Glycolates/therapeutic use , Lactic Acid/therapeutic use , Resorcinols/therapeutic use , Salicylates/therapeutic use , Salicylic Acid/therapeutic use , Acne Vulgaris/diagnosis , Adult , Drug Combinations , Drug Therapy, Combination , Esthetics , Female , Humans , Male , Prognosis , Prospective Studies , Severity of Illness Index , Single-Blind Method , Treatment Outcome , Young AdultABSTRACT
No abstract available.
Subject(s)
Child, Preschool , Humans , Male , Erythema Nodosum , Erythema , Granuloma Annulare , Granuloma , Lower ExtremityABSTRACT
Keloids are benign cutaneous lesions that result from excessive collagen synthesis and deposition. Earlobe keloids are commonly seen as a complication of earlobe piercing and infection. Many different treatment modalities are available; however, therapeutic results are often unsatisfactory. Cryosurgery either used as monotherapy or in combination has been used successfully. However, keloids may require multiple sessions to achieve significant improvement and have a high rate of recurrence. Compared to conventional cryosurgery, intralesional cryosurgery has advantages of proper freezing of the deep layer of the lesion and a less harmful effect on the superficial layers. Herein, we present three cases of earlobe keloid effectively treated with intralesional cryosurgery.
Subject(s)
Collagen , Cryosurgery , Freezing , Keloid , RecurrenceABSTRACT
Primary cutaneous mucinous carcinoma (PCMC) is a rare malignant tumor believed to originate from the eccrine gland. It is important to exclude other possible origins of the mucinous carcinoma, such as the breast, lung, gastrointestinal tract, kidney, prostate, and ovary, because PCMC generally shows a better prognosis. Some histopathological clues are helpful to distinguish PCMC from metastatic mucinous carcinoma, but the final diagnosis should be made after a thorough systemic evaluation. We report a case of PCMC after a comprehensive evaluation to exclude metastatic mucinous carcinoma.
Subject(s)
Female , Adenocarcinoma, Mucinous , Breast , Diagnosis , Eccrine Glands , Gastrointestinal Tract , Kidney , Lung , Mucins , Ovary , Prognosis , Prostate , ScalpABSTRACT
Primary cutaneous mucinous carcinoma (PCMC) is a rare malignant tumor believed to originate from the eccrine gland. It is important to exclude other possible origins of the mucinous carcinoma, such as the breast, lung, gastrointestinal tract, kidney, prostate, and ovary, because PCMC generally shows a better prognosis. Some histopathological clues are helpful to distinguish PCMC from metastatic mucinous carcinoma, but the final diagnosis should be made after a thorough systemic evaluation. We report a case of PCMC after a comprehensive evaluation to exclude metastatic mucinous carcinoma.
Subject(s)
Female , Adenocarcinoma, Mucinous , Breast , Diagnosis , Eccrine Glands , Gastrointestinal Tract , Kidney , Lung , Mucins , Ovary , Prognosis , Prostate , ScalpABSTRACT
Seborrheic keratosis is a common benign epithelial tumor which occurs primarily on sun-exposed area, and is occasionally associated with several malignant or premalignant conditions. Among these malignant or premalignant conditions, Bowen disease and basal cell carcinoma are common, but still it is not clear whether these malignancies arise incidentally with seborrheic keratosis or malignant transformation has occurred. We herein report a case of Bowen disease with seborrheic keratosis on the inguinal area where prior seborrheic keratosis had recurred after incomplete removal.
