ABSTRACT
BACKGROUND: Single-session intraoperative radiation therapy (IORT) minimizes treatment demands associated with traditional whole breast radiation therapy (WBRT) but outcomes on local disease control and morbidity among the elderly is limited. METHODS: A multi-institutional retrospective registry was established from 19 centers utilizing IORT from 2007 to 2013. Patient, tumor, and treatment variables were analyzed for ages <70 and ≥70. RESULTS: We evaluated 686 patients (<70 = 424; ≥70 = 262) who were margin and lymph node negative. Patients <70 were more likely to have longer operative time, oncoplastic closure, higher rates of IORT used as planned boost, and receive chemotherapy and post-operative WBRT. Wound complication rates were low and not significantly different between age groups. Median follow-up was 1.06 (range 0.51-1.9) years for < 70 and 1.01 (range 0.5-1.68) years for ≥ 70. There were 5 (0.73%) breast recurrences (4 in <70 and 1 ≥ 70, p = 0.65) and no axillary recurrences during follow-up. CONCLUSIONS: IORT was associated with a low rate of wound complication and local recurrence on short-term follow-up in this cohort.
Subject(s)
Breast Neoplasms/radiotherapy , Intraoperative Care , Age Factors , Aged , Aged, 80 and over , Breast Neoplasms/pathology , Breast Neoplasms/surgery , Combined Modality Therapy , Female , Humans , Mastectomy, Segmental , Middle Aged , North America , Operative Time , Postoperative Complications/epidemiology , Retrospective Studies , Treatment OutcomeABSTRACT
Five sericea lespedeza (Lespedeza cuneata [Dumont] G. Don) breeding lines resistant to Meloidogyne incognita, M. incognita acrita, and M. hapla as seedlings in greenhouse tests and two varieties were resistant to M. incognita acrita in field experiments. Root-knot galling and larvae numbers were less for resistant entries than for the susceptible check when grown in root-knot infested field soil for three growing seasons. Forage yields were as much as 57 times greater for resistant entries than for susceptible check. Lines resistant to M. incognita acrita generally appeared more tolerant to M. javanica than the susceptible check in the field. A population predominantly M. incognita acrita built up on cotton (Gossypium hirsutum L.) and hairy vetch (Vicia villosa L.) shifted to M. javanica under sericea lespedeza.
