[High Serum Concentrations of Uric Acid: Clinical and Prognostic Significance in Chronic Heart Failure].

The article is devoted to the value of asymptomatic hyperuricemia in patients with chronic heart failure (CHF). The review summarizes results of a number of epidemiological reports that have increasingly linked elevated serum uric acid with an increased risk of incident CHF and adverse outcomes in CHF patients. Pharmacological and non-pharmacological approaches to influencing disturbances of uric acid metabolism are discussed.

[Hyperuricemia and cardiovascular continuum].

Many recent reports suggest the relationship between hyperuricemia, risk and prognosis of arterial hypertension and coronary heart disease. The works on the clinical and prognostic significance in chronic heart failure are few even if this pathology deteriorates prognosis of some cardiovascular diseases. Hyperuricemia is considered to be a component of cardiovascular continuum, risk factor of chronic heart failure and marker of its unfavourable outcome. Prognostic significance of hyperuricemia in patients with chronic heart failure is discussed.

[Clinical implication of the body mass and waist/thigh indices in hypertensive patients: correlations with blood uric acid levels]. / Klinicheskoe znachenie indeksa massy tela i indeksa taliia/bedro u patsientov s arterial'noi gipertoniei: sviaz' s urovnem mochevoi kisloty v krovi.

Body mass index (BMI) and waist/thigh circumference (WTC) were estimated in 104 patients with mild and moderate arterial hypertension (AH) lasting for 8.4 +/- 3.2 years (63 men, 41 women, mean age 50.2(+)-9.6 years). Blood concentration of uric acid was tested with enzymes (Boehringer Mannheim kits). Only 5 of 104 examinees had BMI under 25. The majority of the patients (79%) had high WTC. Hyperuricemia was detected in 32 of 104 patients. Uric acid level in the blood correlates (r = 0.43) with WTC but not with BMI.

[Relationship between mass of the left ventricular myocardium and uric acid metabolic imbalance in patients with arterial hypertension]. / Sviaz' mezhdu massoi miokarda levogo zheludochka i narusheniem obmena mochevoi kisloty u bol'nykh arterial'noi gipertoniei.

AIM: To analyse relationships between left ventricular myocardium mass (LVMM) and imbalance of uric acid metabolism in patients with arterial hypertension (AH). MATERIAL AND METHODS: Body mass index, waist/hip circumference index, levels of uric acid in the blood and urine, urinary excretion of albumin, LVMM were estimated in 106 patients with mild and moderate AH (70 males and 36 females, mean age 51 +/- 8.5 years). RESULTS: Hypertensive patients with and without metabolic imbalance of uric acid differ significantly by LVMM index. The latter was higher in metabolic imbalance of uric acid, being the highest if this imbalance combined with microalbuminuria. CONCLUSION: Imbalance of uric acid metabolism in AH patients may indicate affection of both the kidneys and the heart.

[Urate affection of kidneys and metabolic disturbances in hypertensive patients]. / Uratnoe porazhenie pochek i metabolicheskie sdvigi u patsientov s arterial'noi gipertoniei.

AIM: To detect urate renal affection and correlations between purine metabolism, hyperinsulinemia, obesity, dyslipidemia in patients with arterial hypertension (AH). MATERIALS AND METHODS: 78 patients with mild, moderate and severe hypertension have undergone 24-h monitoring of arterial pressure and microalbuminuria test. RESULTS: Hyperuricemia was diagnosed in 21 of 78, hyperuricosuria in 27 patients. 13 patients had combination of hyperinsulinemia with obesity, dyslipidemia, arterial hypertension. Renal symptoms occurred in almost half of the patients with hyperuricemia. Disturbed 24-h rhythm and variability of arterial pressure were encountered more frequently in patients with hyperuricemia and hyperinsulinemia than in patients with normal purin metabolism and no other metabolic shifts. CONCLUSION: Renal abnormalities were found more frequently in hypertensive patients with hyperuricemia and those free of urate disturbances and metabolic changes. A positive correlation exists between body mass index and insulinemia (r = 0.58, p < 0.01), body mass index and uricemia (r = 0.37, p < 0.01), insulinemia and uricemia (r = 0.32, p < 0.01).