Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 5 de 5
Filter
Add more filters










Database
Language
Publication year range
2.
Heart Lung ; 50(3): 437-440, 2021.
Article in English | MEDLINE | ID: mdl-33631467

ABSTRACT

Spontaneous Pneumothorax in the setting of coronavirus disease 19 (COVID-19) has been rarely described and is a potentially lethal complication. We report our institutional experience. Patients with confirmed COVID-19 who were admitted at 5 hospitals within the Inova health system between February 21 and May 2020 were included in the study. We identified 1619 patients, 22 patients (1.4%) developed spontaneous pneumothorax during their hospitalization without evidence of traumatic injury.


Subject(s)
COVID-19 , Pneumothorax , Humans , Pneumothorax/diagnosis , Pneumothorax/etiology , SARS-CoV-2 , Tomography, X-Ray Computed
3.
BMJ Case Rep ; 13(12)2020 Dec 13.
Article in English | MEDLINE | ID: mdl-33318242

ABSTRACT

A 63-year-old woman on flecainide, furosemide, and triamterene-hydrochlorothiazide presented with weakness and diarrhoea. She had profound hyponatraemia, hypokalaemia and a pre-renal acute kidney injury (AKI). Her ECG showed a regular wide complex tachycardia concerning for monomorphic ventricular tachycardia. She was haemodynamically stable and treated with aggressive electrolyte repletion and amiodarone. Flecainide toxicity can present as a variety of arrhythmias and early recognition is crucial. This case focuses on flecainide toxicity from multiple concomitant insults: diuretic use, diarrhoea, hypokalaemia, hyponatraemia and pre-renal AKI. We emphasise the importance of close outpatient monitoring of electrolytes in a patient on diuretics and flecainide to prevent life-threatening arrhythmias. We discourage use of multiple diuretics in patients taking flecainide.


Subject(s)
Flecainide/toxicity , Tachycardia, Ventricular/chemically induced , Voltage-Gated Sodium Channel Blockers/toxicity , Amiodarone/therapeutic use , Electrocardiography , Female , Humans , Middle Aged , Tachycardia, Ventricular/diagnosis , Tachycardia, Ventricular/drug therapy
4.
J Community Hosp Intern Med Perspect ; 10(6): 521-522, 2020 Oct 29.
Article in English | MEDLINE | ID: mdl-33194121

ABSTRACT

Although respiratory symptoms are the dominant features of COVID-19 infection, myocardial injury has been described in these patients. Reported cardiac manifestations of COVID-19 infection include myocarditis, arrhythmia and acute coronary syndrome including ST elevation myocardial infarction (STEMI). STEMI is a medical emergency and timely intervention is of utmost importance to prevent mortality and long-term morbidities. In this report, we present a wide spectrum of clinical presentations, management, and outcomes for five patients with COVID-19 infection and ST elevation on ECG.

5.
J Biomed Opt ; 20(5): 051008, 2015 May.
Article in English | MEDLINE | ID: mdl-25423046

ABSTRACT

There is an urgent need for rapid methods to develop vaccines in response to emerging viral pathogens. Whole inactivated virus (WIV) vaccines represent an ideal strategy for this purpose; however, a universal method for producing safe and immunogenic inactivated vaccines is lacking. Conventional pathogen inactivation methods such as formalin, heat, ultraviolet light, and gamma rays cause structural alterations in vaccines that lead to reduced neutralizing antibody specificity, and in some cases, disastrous T helper type 2-mediated immune pathology. We have evaluated the potential of a visible ultrashort pulsed (USP) laser method to generate safe and immunogenic WIV vaccines without adjuvants. Specifically, we demonstrate that vaccination of mice with laser-inactivated H1N1 influenza virus at about a 10-fold lower dose than that required using conventional formalin-inactivated influenza vaccines results in protection against lethal H1N1 challenge in mice. The virus, inactivated by the USP laser irradiation, has been shown to retain its surface protein structure through hemagglutination assay. Unlike conventional inactivation methods, laser treatment did not generate carbonyl groups in protein, thereby reducing the risk of adverse vaccine-elicited T helper type 2 responses. Therefore, USP laser treatment is an attractive potential strategy to generate WIV vaccines with greater potency and safety than vaccines produced by current inactivation techniques.


Subject(s)
Influenza Vaccines/chemistry , Orthomyxoviridae Infections/prevention & control , Animals , Antibodies, Neutralizing/blood , Antibodies, Viral/blood , CD8-Positive T-Lymphocytes/cytology , Cell Line , Dogs , Female , Hemagglutination Tests , Humans , Influenza A Virus, H1N1 Subtype , Influenza, Human/prevention & control , Lasers , Mice , Mice, Inbred BALB C , Microscopy, Electron, Transmission , Neutralization Tests , Vaccination , Vaccines, Inactivated/chemistry
SELECTION OF CITATIONS
SEARCH DETAIL
...