ABSTRACT
Amino acid metabolism was studied experimentally during prolonged administration of a mixture of organochlorine, -metallic, and -phosphorus pesticides and in subjects occupationally exposed to pesticides for a long time. A marked increase of blood serum and liver levels of ser, glu, gly, ala, val, isolei, tyr, phen and a decrease of cystine were detected in white rats. Blood serum serine and threonine hydratases activities increased in parallel with increase of pesticide mixture dose. Reduced levels of taurine, cystine, methionine, alanine and increased levels of phenylalanine were revealed in subjects after prolonged exposure to pesticides. Analysis of blood serum amino acid metabolism parameters may be used as diagnostic criteria of metabolic disorders in a body exposed to pesticides.
