ABSTRACT
The results of the study of the level of pancreatic hormones (insulin, glucagon, C-peptide and trypsin), carried out with the aim of finding out the character of relationship between hormonal disturbances and the state of carbohydrate metabolism, as well as the influence of oral rehydration therapy (ORT) with glucose-salt solutions on the function of the pancreas, are summarized. All subjects to be examined were divided into two groups receiving different kinds of ORT. The patients in group 1 (153 subjects) were treated with glucosolan and in group 2 (73 subjects), with sodium citrate in an amount of 2.5-5 lit. over the 6-hour period of treatment. The determination of the content of immunoreactive insulin, glucagon C-peptide and trypsin in the blood as the characteristics of the hormonal activity of the pancreas has made it possible to find out disturbances in the incretory and excretory activity of the pancreas in patients with acute enteric infections of different etiology. ORT with glucosolan and sodium citrate facilitates the restoration of pancreatic function in 65-70% of in patients with acute enteric infections of different etiology.
Subject(s)
Dysentery, Bacillary/therapy , Fluid Therapy , Intestinal Diseases/therapy , Pancreas/physiopathology , Salmonella Food Poisoning/therapy , Vibrio Infections/therapy , Acute Disease , Adolescent , Adult , Blood Glucose/analysis , Dysentery, Bacillary/blood , Dysentery, Bacillary/physiopathology , Female , Fluid Therapy/methods , Humans , Intestinal Diseases/blood , Intestinal Diseases/physiopathology , Male , Pancreatic Hormones/blood , Salmonella Food Poisoning/blood , Salmonella Food Poisoning/physiopathology , Vibrio Infections/blood , Vibrio Infections/physiopathologyABSTRACT
ORT effectiveness for AII cases of different etiology was studied in two groups of patients: 153 patients as ORT received glucosalan (group 1), 75 patients underwent ORT with sodium citrate in solution from 2.5 to 51 within 6 hours. Both group 1 and group 2 patients benefited from the above solutions as following 6 hours of treatment their biochemical and clinical indices improved. The patients attained normal coagulation, filter-reabsorption renal function under disappearance of dehydration and intoxication symptoms. Availability and simplicity of ORT procedure enable its usage prior to hospitalization, in outpatient departments, at home, making hospitalization unnecessary if started at the initial AII stages.
Subject(s)
Bacterial Infections/therapy , Dehydration/therapy , First Aid/methods , Fluid Therapy/methods , Intestinal Diseases/therapy , Adolescent , Adult , Bacterial Infections/complications , Bacterial Infections/physiopathology , Dehydration/etiology , Dehydration/physiopathology , Evaluation Studies as Topic , Female , Humans , Intestinal Diseases/complications , Intestinal Diseases/physiopathology , Male , Time FactorsABSTRACT
RIA was used to measure the content of insulin, C-peptide and glucagon in blood plasma of 84 patients with acute dysentery and food toxicoinfections. The studies were carried out in the acute disease period and before the discharge from hospital. The data obtained indicate that despite the appreciable differences in the disease pathogenesis, the pathophysiological mechanisms influencing pancreatic function are similar in many respects. The changes are characterized by an increase in plasma insulin and a reduction in C-peptide and glucagon. The content of hormones in the peripheral blood is dependent on the disease period. In the authors' opinion, despite the high insulin content, the reduced level of C-peptide attests to hypofunction of beta-cells in acute intestinal infection, since it reflects their function more precisely. The reduced content of plasma glucagon points to hypofunction of alpha-cells.
Subject(s)
Dysentery, Bacillary/physiopathology , Foodborne Diseases/physiopathology , Intestinal Diseases/physiopathology , Islets of Langerhans/physiopathology , Shigella boydii , Shigella flexneri , Shigella sonnei , Acute Disease , C-Peptide/blood , Dysentery, Bacillary/blood , Foodborne Diseases/blood , Glucagon/blood , Humans , Insulin/blood , Intestinal Diseases/bloodABSTRACT
The incretory pancreatic function has been studied in 35 patients with a moderately severe course of acute dysentery. The blood plasma content of insulin, glucagon and gastrin was determined by means of radioimmunoassay with standard kits during the acute course of the disease and prior to discharge of patients. The endocrine pancreatic function was found to be deranged with an increased insulin content during convalescence; the glucagon content was decreased during the period of the disease and the gastrin content was decreased in the acute period.
