Alterações posturais e capacidade para o trabalho em acadêmicos do curso de odontologia de uma instituição de ensino superior privada no sertão central cearense / Postural changes and work ability of dentistry students in a private higher education institution in the state of Ceará, Brazil

A profissão exerce influência nas condições de saúde dos trabalhadores, por isso algumas práticas no trabalho exigem cuidado. Durante a realização das práticas odontológicas, os acadêmicos e profissionais adquirem posições estáticas desconfortáveis e inadequadas por períodos de longa duração. O objetivo deste estudo foi avaliar as condições posturais e a capacidade para o trabalho em graduandos do curso de Odontologia do Centro Universitário Católica de Quixadá/CE. Trata-se de um estudo transversal, descritivo e exploratório, com abordagem metodológica quantitativa. A população constituiu-se de 147 alunos do curso de Odontologia da Unicatólica, de ambos os gêneros, no período de 2019.2 a 2020.1. A coleta de dados deu-se por meio do Índice de Capacidade para o Trabalho, e da avaliação postural através do Instrumento de Avaliação Postural, com o auxílio do simetrógrafo. Observou-se que desvios posturais estavam mais presentes no gênero feminino, podendo se explicar pelo seu número mais expressivo, porém não foram detectáveis relações entre a capacidade para o trabalho e as alterações posturais. Foi possível concluir que mesmo com o quantitativo de alterações posturais dos estudantes, apresentavam boa capacidade para o trabalho. (AU)

The profession influences the health conditions of workers, so some practices at work require specific care. During the performance of dental practices, students and professionals acquire uncomfortable and inappropriate positions for long periods. The aim of this study was to evaluate postural conditions and work ability in undergraduate students of the Dentistry course at the Centro Universitário Católica de Quixadá/CE, Brazil. This was a cross-sectional, descriptive, and exploratory study, with a quantitative methodological approach. The population consisted of 147 students from the Unicatólica Dentistry course, of both genders, in the period from 2019.2 to 2020.1. Data collection took place through the Work Ability Index, and the postural assessment through the Postural Assessment Instrument, with the aid of the symmetrograph. Postural deviations were more present in the female gender, which can be explained by their more expressive number, but no relationships were detected between work ability and postural changes. It was possible to conclude that even with the number of postural changes in the students, they had a good capacity for work. (AU)

Antinociceptive, anti-inflammatory and toxicological evaluation of semi-synthetic molecules obtained from a benzyl-isothiocyanate isolated from Moringa oleifera Lam. in a temporomandibular joint inflammatory hypernociception model in rats.

Inflammation is a key component of many clinical conditions that affect the temporomandibular joint (TMJ) and Moringa oleifera Lam. has been used to treat inflammatory diseases. Here, we evaluated the toxicological effects on mice of a naturally-occurring isothiocyanate from M. oleifera and its seven analogue molecules. Further, the anti-nociceptive and anti-inflammatory effects on a rat model of TMJ inflammatory hypernociception were assessed. The systemic toxicological profile was determined in mice over a 14-day period: MC-1 1 µg/kg; MC-D1 1 µg/kg, MC-D3 100 µg/kg, MC-D6 1 µg/kg, MC-D7 1 µg/kg, MC-D8 1 µg/kg, MC-D9 10 µg/kg, and MC-H 1 µg/kg. The safest molecules were assayed for anti-nociceptive efficacy in the formalin (1.5%, 50 µL) and serotonin (255 mg) induced TMJ inflammatory hypernociception tests. The anti-inflammatory effect was evaluated through the vascular permeability assay using Evans blue. Further, the rota-rod test evaluated any motor impairment. Among the tested molecules, MC-D7, MC-D9, and MC-H were not toxic at the survival rate test, biochemical, and hystological analysis. They reduced the formalin-induced TMJ inflammatory hypernociception, but only MC-H decreased the serotonin-induced TMJ inflammation, suggesting an adrenergic receptor-dependent effect. They diminished the plasmatic extravasation, showing anti-inflammatory activity. At the rota-rod test, no difference was observed in comparison with control groups, reinforcing the hypothesis of anti-nociceptive effetc without motor impairment in animals. The analogues MC-D7, MC-D9, and MC-H were safe at the tested doses and efficient in reducing the formalin-induced TMJ hypernociception in rats. Our next steps include determining their mechanisms of anti-nociceptive action.