[Clinical signification of a modified dilution method (MDM) for blood loss assessment in the cases of nonvariceal upper gastrointestinal bleeding].

The aim of this study was to compare the modified dilution method (MDM) for in vivo bloodless assessment with the accepted in the clinical practice methods. We measured 148 blood samples from 134 patients with nonvariceal upper gastrointestinal bleeding (NUGB) and 21 blood samples from healthy persons as a negative control. In the randomized group of 53 patients with NUGB we compared accuracy of the blood loss determination by means of erythrocyte mass loss (estimated with MDM), Allgower-Burri index and American College of Surgeon Index (ACSI). The obtained results give us a reason to recommend a combination between American College of Surgeon classification for blood loss in patients with NUGB and a parallel measurement of the MDM values.

[Glycosylated serum proteins in the early diagnosis of diabetes mellitus]. / Glikirani serumni beltutsi v rannata diagnoza na zakharniia diabet.

In order to determine the information value of glycosilated serum proteins concentrations a parallel examination of these proteins and the oral glucose tolerance test was carried out on 104 diabetic patients and healthy controls. The results revealed a high degree correlation -r = 0.80. The advantages of the determination of the glycosilated serum proteins for the clinical and laboratory practice are discussed. The analysis is automized, available and cheap and is not influenced by food intake.

[Dynamic changes in the blood glucose, glycosylated hemoglobin and glycosylated serum protein values in patients with diabetes mellitus]. / Dinamichni promeni v stoinostite na kruvnata gliukoza, glikoziliraniia khemoglobin i gliukoziliranite serumni beltutsi pri bolni ot zakharen diabet.

In 30 diabetic patients blood glucose, HbA1 and glycosylated serum proteins were studied. They were examined at the beginning of the treatment and at 7-day intervals. On the 7th day considerable changes of blood glucose level were found without reliable changes of HbA1 and glycosylated serum protein level. On the 14th day a reliable decrease of the glycosylated serum proteins from 2.45 to 1.82 mumol/g protein was registered (p less than 0.01). After a 4 week treatment reliable changes of HbA1 level from 11.25 to 9.54% was found (p less than 0.01). Significant correlations between glucose and HbA1 values (r = 0.57) and between glucose and glycosylated proteins (r = 0.82) were established.

[2,3-diphosphoglycerate level during the active and maintenance treatment of iron-deficiency anemia patients]. / Nivo na 2,3-difosfoglitserata po vreme na aktivno i poddurzhashto lechenie na bolni ot zheliazodefitsitna anemiia.

The objective of the present study was to obtain information about the duration of tissue hypoxia in patients with iron deficiency anemia. That fact is of importance for the determination of the duration of maintenance iron therapy. The level of 2,3-diphosphoglycerate was studied during the treatment, after the correction of anemic syndrome and after 60-day out-patient department treatment. The data obtained revealed that the level of 2,3-diphosphoglycerate was considerably elevated, as compared with the norm, before the treatment. After the active treatment and correction of anemic syndrome it was decreased, but remaining above the norm. By the 60th day of the out-patient department treatment the decrease continued and the level of 2,3-diphosphoglycerate approached the norm.