Subject(s)
Arthritis, Rheumatoid/diagnosis , Axis, Cervical Vertebra , Cervical Atlas , Occipital Bone , Adult , Arthritis, Rheumatoid/diagnostic imaging , Axis, Cervical Vertebra/diagnostic imaging , Cervical Atlas/diagnostic imaging , Female , Humans , Male , Middle Aged , Occipital Bone/diagnostic imaging , RadiographyABSTRACT
A pilot single-blind placebo controlled crossover within-patient study was undertaken in essential hypertension. In ten patients single daily doses of 25 mg and 50 mg and in two patients 25 mg, 50 mg and 100 mg were used. Satisfactory reductions in both systolic and diastolic blood pressure in the supine and erect postures were observed. Reduction in heart rate was of the order of 6-32%, there being no correlation between reductions in blood pressure and decrements in heart rate. Three patients were dropped from the final analyses. Seventy-eight per cent (7/9) of patients had a final diastolic pressure (lying) of 90 mm Hg or less. Single doses of penbutolol controlled blood pressure for at least twenty-four hours. At the end of two weeks on placebo medication, following nine weeks of active drug medication, blood pressure had reverted to near pre-treatment levels. Penbutolol was well tolerated.
Subject(s)
Antihypertensive Agents/administration & dosage , Hypertension/drug therapy , Propanolamines/administration & dosage , Adult , Aged , Antihypertensive Agents/pharmacology , Antihypertensive Agents/therapeutic use , Clinical Trials as Topic , Drug Administration Schedule , Female , Heart Rate/drug effects , Humans , Male , Middle Aged , Pilot Projects , Placebos , Posture , Propanolamines/pharmacology , Propanolamines/therapeutic useSubject(s)
Bites and Stings/complications , Myocarditis/etiology , Scorpions , Adolescent , Adult , Electrocardiography , Female , Humans , Male , Middle Aged , Myocarditis/diagnosisSubject(s)
Diazepam/therapeutic use , Tetanus/drug therapy , Adolescent , Adult , Child , Child, Preschool , Clinical Trials as Topic , Diazepam/pharmacology , Drug Evaluation , Drug Therapy, Combination , Female , Humans , India , Infant , Infant, Newborn , Infant, Newborn, Diseases/drug therapy , Male , Middle Aged , Spasm/drug therapySubject(s)
Myocarditis/etiology , Rabies/complications , Adolescent , Adult , Aged , Child , Child, Preschool , Electrocardiography , Female , Humans , Male , Myocarditis/diagnosis , Tachycardia/diagnosis , Tachycardia/etiologySubject(s)
Ichthyosis/complications , Leprosy/complications , Adult , Female , Humans , Ichthyosis/pathology , Leprosy/pathologySubject(s)
Diabetic Coma , Emergencies , Hyperglycemia , Adult , Aged , Child , Dehydration/therapy , Diabetic Coma/diagnosis , Diabetic Coma/drug therapy , Diabetic Coma/metabolism , Female , Humans , Hyperglycemia/diagnosis , Hyperglycemia/drug therapy , Hyperglycemia/metabolism , Insulin/therapeutic use , Ketone Bodies/biosynthesis , Liver/metabolism , Male , Middle Aged , Osmolar Concentration , PrognosisSubject(s)
Interferons , Adult , Animals , Antigens , Child , Humans , Interferons/biosynthesis , Interferons/isolation & purification , Interferons/pharmacology , Interferons/therapeutic use , Neoplasms/drug therapy , Phagocytes/metabolism , RNA, Messenger , Species Specificity , Viral Proteins/biosynthesis , Virulence , Virus Diseases/drug therapy , Virus Replication/drug effectsSubject(s)
Proinsulin , Adenoma, Islet Cell/metabolism , Adipose Tissue/drug effects , Amino Acid Sequence , Animals , Binding Sites, Antibody , Cattle , Epitopes , Humans , Immunoassay , In Vitro Techniques , Insulin/biosynthesis , Islets of Langerhans/metabolism , Muscles/drug effects , Proinsulin/analysis , Proinsulin/biosynthesis , Proinsulin/blood , Proinsulin/pharmacology , Proinsulin/urine , Protein Conformation , Ribosomes/metabolism , Species Specificity , Swine , TrypsinABSTRACT
Antazoline was administered in sixty-five episodes of various types of cardiac arrhythmia. A complete suppression of the ectopic beats was achieved in five out of six episodes of premature atrial systoles and in twenty-one of the twenty-four episodes of ventricular premature systoles. Conversion to sinus rhythm was observed in seven out of ten and four out of five episodes of paroxysmal atrial and nodal tachycardia respectively. Six out of ten episodes of ventricular tachycardia were controlled by intravenous therapy. However, the drug proved to be ineffective in cases of atrial fibrillation. The side-effects were few and transitory, consisting of nausea, vomiting and drowsiness.
