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1.
J Natl Med Assoc ; 95(1): 77-81, 2003 Jan.
Article in English | MEDLINE | ID: mdl-12656453

ABSTRACT

Nasopharyngeal carcinoma is endemic in China, Hong Kong, and the Philippines. However, this disease is rare in North America and the Caribbean. This paper discusses the clinical features, prognosis, treatment outcomes, and survival rates of nasopharyngeal carcinoma in Jamaica. The incidence in Jamaica is 1.4 per 100,000. The National Cancer Registry in Jamaica keeps a record of all cancers. A retrospective cohort study of patients with nasopharyngeal carcinoma between 1988-2000 was reviewed. The presenting features, staging, histological diagnosis, treatment, and patient outcome were assessed. All patients received radiation therapy, and 89% of the patients completed the course of therapy. Seventeen percent received chemotherapy, consisting of cisplatin and 5-fluorouracil. Surgery played a minor role in the definitive management of nasopharyngeal carcinoma in this study. Three-year survival rates were 21%. The study demonstrates findings unique to the Caribbean nation of Jamaica. There is a bimodal pattern to the age distribution typical in non-endemic areas, such as shown in this study. Nasopharyngeal carcinoma evades early diagnosis because of its anatomic location and varied symptomatology. Prognostic indicators include intracranial extension, cervical node, and distant metastasis.


Subject(s)
Nasopharyngeal Neoplasms/epidemiology , Adolescent , Adult , Age Distribution , Aged , Child , Cohort Studies , Female , Humans , Incidence , Jamaica/epidemiology , Male , Middle Aged , Nasopharyngeal Neoplasms/diagnosis , Nasopharyngeal Neoplasms/therapy , Retrospective Studies , Survival Rate
2.
Lancet ; 360(9329): 310-2, 2002 Jul 27.
Article in English | MEDLINE | ID: mdl-12147378

ABSTRACT

In Iquitos, Peru, no cases of dengue haemorrhagic fever have been recorded in individuals infected with dengue-1 virus followed by American genotype dengue-2 (American dengue-2) virus. We assayed serum samples collected in Iquitos that tested positive for antibodies of monotype dengue-1 and monotype dengue-2 using a plaque reduction neutralisation test to determine their ability to neutralise the infectivity of two dengue-1 viruses, two American dengue-2 viruses, and two Asian dengue-2 viruses. Sera positive for the dengue-1 antibody neutralised dengue-1 viruses and American dengue-2 viruses much more effectively than Asian dengue-2 viruses. Neutralisation of American dengue-2 virus by sera positive for dengue-1 antibodies may account for the absence of dengue haemorrhagic fever in individuals infected with dengue-1 in 1990-91 followed by American dengue-2 virus in 1995 in Iquitos, Peru.


Subject(s)
Antibodies, Viral/blood , Dengue Virus/classification , Dengue/immunology , Dengue Virus/immunology , Humans , Peru , Polymerase Chain Reaction , Serotyping , Severe Dengue/immunology
3.
Rev. med. exp ; 14(1): 25-28, ene.-jun. 1997. ilus
Article in Spanish | LILACS, INS-PERU | ID: lil-340771

ABSTRACT

El potencial diagnóstico de epitopes inmunodominantes seleccionados fue ensayado satisfactoriamente a fin de obtener una prueba serodiagnóstica alternativa para la Leishmaniasis Tegumentaria Americana. Dos proteínas recombinantes prometedoras de L. (v.) peruviana referidas como T-26-U2/T26-U4 fueron reconocidas por sueros individuales de pacientes con Leishmaniasis Tegumentaria Americana usuando Western Blot. La sensibilidad de la prueba fue de 86 con sueros permanetes con Leishmaniasis peruana


Subject(s)
Leishmaniasis , Blotting, Western , Leishmania
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