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Merkel cell polyomavirus strains in patients with merkel cell carcinoma.
Touzé, Antoine; Gaitan, Julien; Maruani, Annabel; Le Bidre, Emmanuelle; Doussinaud, Angélique; Clavel, Christine; Durlach, Anne; Aubin, François; Guyétant, Serge; Lorette, Gérard; Coursaget, Pierre.
Emerg Infect Dis ; 15(6): 960-2, 2009 Jun.
Article in English | MEDLINE | ID: mdl-19523303

ABSTRACT

We investigated whether Merkel cell carcinoma (MCC) patients in France carry Merkel cell polyomavirus (MCPyV) and then identified strain variations. All frozen MCC specimens and 45% of formalin-fixed and paraffin-embedded specimens, but none of the non-MCC neuroendocrine carcinomas specimens, had MCPyV. Strains from France and the United States were similar.


Subject(s)
Carcinoma, Merkel Cell/virology , Merkel Cells/virology , Polyomavirus Infections/virology , Polyomavirus , Skin Neoplasms/virology , Tumor Virus Infections/virology , Aged , Aged, 80 and over , Capsid Proteins/genetics , DNA, Viral/analysis , Female , France/epidemiology , Humans , Male , Middle Aged , Molecular Sequence Data , Polymerase Chain Reaction/methods , Polyomavirus/classification , Polyomavirus/genetics , Polyomavirus/isolation & purification , Sequence Analysis, DNA
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