ABSTRACT
A study was made of the effect of dioxyacetone, a natural metabolite of carbohydrate metabolism, on blood rheological properties of man in vitro and experimental animals, with the drug being injected intravenously. It was discovered both in vitro and in vivo that dioxyacetone exhibits the remarkable rheological efficacy, provided its concentration in the blood amounts to 100 mg/100 ml.
Subject(s)
Blood Viscosity/drug effects , Dihydroxyacetone/pharmacology , Erythrocyte Aggregation/drug effects , Trioses/pharmacology , Animals , Blood Flow Velocity/drug effects , Dihydroxyacetone/administration & dosage , Dogs , Hematocrit , Humans , In Vitro Techniques , Infusions, Parenteral , Time FactorsSubject(s)
Cellulose , Extracorporeal Circulation/methods , Thoracic Surgery , Thorax/surgery , Adolescent , Animals , Blood Physiological Phenomena , Blood Preservation , Cardiac Surgical Procedures/methods , Child , Child, Preschool , Dogs , Female , Heparin , Humans , Male , Organophosphorus CompoundsSubject(s)
Blood Preservation/methods , Cellulose/pharmacology , Blood Donors , Borates , Drug Stability , PhosphatesABSTRACT
It is shown that freshly stored stabilized blood differs in its effect on a recipient only on account of addition of stabilizors to it. The replacement effect due to transfusion of freshly preserved citrated blood is analogous to that noted in direct blood transfusion, however the response of the cardiovascular system inadequate for the transfused blood volume would restrict the rate and volume of transfusion. Freshly heparinized blood differs from donor blood by impaired coagulation factors, but it is identical in hemodynamic effect. Freshly preserved sorbent blood is mostly close in its efficacy to direct transfusions, since its content differs from native donor blood only in calcium content.
Subject(s)
Blood Preservation , Blood Transfusion/methods , Blood Cell Count , Blood Coagulation Factors/analysis , Electrolytes/blood , Evaluation Studies as Topic , HumansABSTRACT
The Institute of General and Inorganic Chemistry of the BSSR Academy of Sciences and the Byelorussian Research Institute of Blood Transfusion have developed and used in hospital practice a fundamentally new method of blood stabilization which does not require addition of alliens. Some part of calcium from blood plasma is extracted by filtrating the blood through layers of specially developed highly effective and biologically compatible fibrous sorbents of derivatives of cellulose (natural highpolymer). The blood may the used in all cases of homotransfusion and most expediently in extremely complicated cases, when direct blood transfusions are difficult. Stabilized blood may also be effectively used when large-quantity or exchange blood transfusions have to be quickly performed, to resuscitate patients from clinical death, to stop haemorrhage caused by disturbances in blood coagulation, to treat anaemia of different etiology, including radiation illness, and in case of sensitiveness to citrate solutions (serious affections of kidneys, liver and heart).
