ABSTRACT
Cryptosporidium parvum causes severe long-standing diarrhea in immunocompromised patients. Sclerosing cholangitis caused by C. parvum is a rare complication in transplant recipients. We report herein the presentation of Cryptosporidium-associated cholangitis in an adult liver transplant patient diagnosed by liver biopsy. The patient improved on treatment with azithromycin and paromomycin.
Subject(s)
Cholangitis, Sclerosing/parasitology , Cryptosporidiosis/complications , Cryptosporidium parvum/pathogenicity , Liver Transplantation/immunology , Animals , Azithromycin/therapeutic use , Cholangitis, Sclerosing/drug therapy , Humans , Immunocompromised Host , Liver Transplantation/adverse effects , Male , Middle Aged , Paromomycin/therapeutic use , Treatment OutcomeABSTRACT
Cerebral phaeohyphomycosis is a rare disease caused by dematiaceous (darkly pigmented) fungi. Cladophialophora species are highly neurotropic, and Cladophialophora bantiana (synonym=Xylohypha bantiana or C. trichoides) is the most commonly identified agent. Most reported cases of cerebral phaeohyphomycosis have occurred in immunocompetent patients; however, some case reports and experimental data have suggested that cellular immune deficiency is a risk factor. We report a case of pulmonary and cerebral phaeohyphomycosis in a cardiac transplant patient due to a newly identified species of Cladophialophora. Optimal management includes both antifungal therapy and surgery.
Subject(s)
Brain Diseases/microbiology , Central Nervous System Fungal Infections/immunology , Adult , Female , Humans , Immunocompetence , Mycoses/immunology , Phialophora/isolation & purificationABSTRACT
Vibrio vulnificus is responsible for severe infections in chronically ill patients. Organ transplant recipients are also at risk for severe infections due to V vulnificus. We report here the first case of V. vulnificus primary bacteremia due to raw shellfish consumption in a liver transplant recipient. All transplant patients should be cautioned against consuming uncooked seafood and warned about the risk of severe Vibrio infections from seemingly innocuous wounds acquired in a salt water environment.