1.
Org Lett
; 15(12): 2942-5, 2013 Jun 21.
Article
in English
| MEDLINE
| ID: mdl-23751116
ABSTRACT
An efficient, asymmetric synthesis of the 5-HT2C agonist vabicaserin in four chemical steps and 54% overall yield from commercially available benzodiazepine was achieved. The synthesis was highlighted by a novel oxidative, multicomponent reaction to affect the quinolinium ring assembly in one step followed by an unprecedented asymmetric hydrogenation of a 3,4-substituted quinolinium salt.