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Bioorg Khim ; 22(7): 557-9, 1996 Jul.
Article in Russian | MEDLINE | ID: mdl-8992962

ABSTRACT

A series of structural analogs of putrescine, spermidine, and spermine with the aminomethylene fragment substituted by the aminooxy group was suggested. The synthesis of the new aminooxy analogs of spermine was described. Biochemical aspects of the activity of the aminooxy analogs of polyamines were discussed in respect of their selective inhibition of normal and leukemic cells.


Subject(s)
Putrescine/analogs & derivatives , Spermidine/analogs & derivatives , Spermine/analogs & derivatives , Animals , Cell Division/drug effects , Cell Line , Cricetinae , Leukemia L1210/pathology , Putrescine/pharmacology , Spermidine/pharmacology , Spermine/pharmacology , Tumor Cells, Cultured
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