ABSTRACT
Mycoplasmal infections may be complicated by a wide variety of systemic syndromes, including neurological disorders. Circumstantial evidence suggests that these are immunologically-induced. A detailed study of five patients with proven mycoplasma pneumoniae and central nervous system signs showed that immunological factors were involved and suggested that the neurological symptoms were due to a vasculopathy.
Subject(s)
Mycoplasma Infections/diagnosis , Nervous System Diseases/diagnosis , Adult , Brain/pathology , Child , Encephalomyelitis/etiology , Female , Humans , Immune Complex Diseases/diagnosis , Male , Middle Aged , Mycoplasma Infections/immunology , Mycoplasma Infections/pathology , Nervous System Diseases/immunology , Nervous System Diseases/pathology , Polyradiculoneuropathy/etiology , Vascular Diseases/diagnosisABSTRACT
We report here a case of polymyositis and toxoplasmosis, and review the previous examples of this association. We suggest that in most cases this relationship is due to reactivation of latent infection in an immunocompromised host. Gross immunological aberrations underline the pathogenesis of polymyositis and these predispose the patient to the development of toxoplasmosis. Anti-protozoal therapy is necessary and produces some clinical benefit, but it does not cure the polymyositis.
Subject(s)
Myositis/etiology , Toxoplasmosis/complications , Adult , Antibody Formation , Female , HLA Antigens/analysis , Humans , Immunity, Cellular , Myositis/immunology , Toxoplasmosis/immunologyABSTRACT
A case of profound myopathy due to electrolyte disturbances secondary to salmonella enteritis is reported. The relationship between hypomagnesaemia, hypocalcaemia and parathyroid hormone secretion is also demonstrated.
